DE3171202D1 - Process for the preparation of cimetidine - Google Patents

Process for the preparation of cimetidine

Info

Publication number
DE3171202D1
DE3171202D1 DE8181303378T DE3171202T DE3171202D1 DE 3171202 D1 DE3171202 D1 DE 3171202D1 DE 8181303378 T DE8181303378 T DE 8181303378T DE 3171202 T DE3171202 T DE 3171202T DE 3171202 D1 DE3171202 D1 DE 3171202D1
Authority
DE
Germany
Prior art keywords
cimetidine
preparation
methyl
water
mercaptoethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181303378T
Other languages
English (en)
Inventor
Pekka Juhani Kairisalo
Erkki Juhani Honkanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8513706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3171202(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of DE3171202D1 publication Critical patent/DE3171202D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lubricants (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8181303378T 1980-08-21 1981-07-23 Process for the preparation of cimetidine Expired DE3171202D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI802649A FI63753C (fi) 1980-08-21 1980-08-21 Foerfarande foer framstaellning av kristallint simetidin.

Publications (1)

Publication Number Publication Date
DE3171202D1 true DE3171202D1 (en) 1985-08-08

Family

ID=8513706

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181303378T Expired DE3171202D1 (en) 1980-08-21 1981-07-23 Process for the preparation of cimetidine

Country Status (19)

Country Link
EP (1) EP0046635B1 (de)
JP (1) JPH0153272B2 (de)
AT (1) ATE14123T1 (de)
BG (1) BG36786A3 (de)
CA (1) CA1164876A (de)
CS (1) CS220346B2 (de)
DD (1) DD201675A5 (de)
DE (1) DE3171202D1 (de)
DK (1) DK554580A (de)
ES (1) ES8204425A1 (de)
FI (1) FI63753C (de)
GR (1) GR67669B (de)
HU (1) HU188074B (de)
NO (1) NO155440C (de)
PL (1) PL133507B1 (de)
PT (1) PT73478B (de)
RO (1) RO83439B (de)
SU (1) SU1122222A3 (de)
YU (1) YU201481A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59130274A (ja) * 1983-01-14 1984-07-26 Tokawa Tetsuo イミダゾ−ル系化合物の製法
JPS6182818A (ja) * 1984-10-01 1986-04-26 Toray Ind Inc 化学薬品の精製法
GB8618846D0 (en) * 1986-08-01 1986-09-10 Smithkline Beckman Corp Chemical process
JPH0627120B2 (ja) * 1986-11-07 1994-04-13 三井石油化学工業株式会社 新規なα−クロロケトン誘導体および製造法
JPH064601B2 (ja) * 1987-11-04 1994-01-19 三井石油化学工業株式会社 Ｎ−シアノ−ｎ’−メチル−ｎ’’−［２−｛（５−メチル−１ｈ−イミダゾール−４−イル）メチルチオ｝エチルグアニジンの精製法
CN114149348A (zh) * 2021-12-15 2022-03-08 河北新石制药有限公司 西咪替丁缩合杂质的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
US4215217A (en) * 1975-10-29 1980-07-29 Sk&F Lab Co. Process for preparing 4-substituted imidazole compounds
ES458042A1 (es) * 1977-04-06 1978-08-16 Ricorvi S A Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina.
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
ES504698A0 (es) 1982-05-16
CA1164876A (en) 1984-04-03
BG36786A3 (en) 1985-01-15
FI802649A (fi) 1982-02-22
PL133507B1 (en) 1985-06-29
YU201481A (en) 1984-02-29
NO155440C (no) 1987-04-01
JPS5754176A (de) 1982-03-31
FI63753C (fi) 1987-02-19
SU1122222A3 (ru) 1984-10-30
FI63753B (fi) 1983-04-29
RO83439A (ro) 1984-02-21
EP0046635B1 (de) 1985-07-03
ATE14123T1 (de) 1985-07-15
ES8204425A1 (es) 1982-05-16
NO812813L (no) 1982-02-22
HU188074B (en) 1986-03-28
PL232730A1 (de) 1982-04-26
JPH0153272B2 (de) 1989-11-13
EP0046635A1 (de) 1982-03-03
CS220346B2 (en) 1983-03-25
DK554580A (da) 1982-02-22
NO155440B (no) 1986-12-22
GR67669B (de) 1981-09-02
PT73478B (en) 1983-11-30
PT73478A (en) 1981-09-01
RO83439B (ro) 1984-02-28
DD201675A5 (de) 1983-08-03

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: SMITH KLINE & FRENCH LABORATORIES LTD., WELWYN GAR

8339 Ceased/non-payment of the annual fee