ES458042A1 - Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina. - Google Patents
Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina.Info
- Publication number
- ES458042A1 ES458042A1 ES458042A ES458042A ES458042A1 ES 458042 A1 ES458042 A1 ES 458042A1 ES 458042 A ES458042 A ES 458042A ES 458042 A ES458042 A ES 458042A ES 458042 A1 ES458042 A1 ES 458042A1
- Authority
- ES
- Spain
- Prior art keywords
- guanidine
- methyl
- thiol
- cyano
- deriv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title abstract 6
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title abstract 3
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title abstract 3
- 208000007107 Stomach Ulcer Diseases 0.000 title abstract 2
- KEWLVUBYGUZFKX-UHFFFAOYSA-N 2-ethylguanidine Chemical compound CCNC(N)=N KEWLVUBYGUZFKX-UHFFFAOYSA-N 0.000 title 1
- APZXPRHPPCTRHN-UHFFFAOYSA-N 4-(chloromethyl)-5-methyl-1h-imidazole Chemical compound CC=1NC=NC=1CCl APZXPRHPPCTRHN-UHFFFAOYSA-N 0.000 title 1
- 201000005917 gastric ulcer Diseases 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- 150000002460 imidazoles Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- -1 thiol salt Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA SINTESIS DE LA 1-CIANO-2-METIL-3-(2-((5-METIL-IMIDAZOL-4-IL-)METIL)TIO)ETIL)-GUANIDINA CUYA FORMULA ES: **FORMULA** SE HACE REACCIONAR EL 4-CLOROMETIL-5-METIL-IMIDAZOL CON EL 1-CIANO-2-METIL-3-((2-TIOL)ETIL)-GUANIDINA EN MEDIO ALCALINO, EN FORMA DE SAL DE TIOL. POSEE APLICACIONES TERAPEUTICAS.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES458042A ES458042A1 (es) | 1977-04-06 | 1977-04-06 | Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina. |
| FR7732156A FR2386525A1 (fr) | 1977-04-06 | 1977-10-17 | Procede pour la synthese de la 1-cyano-2-methyl-3- (2- (((5-methyl-imidazol-4-yl)methyl)thio)ethyl)-guanidine |
| PT67377A PT67377B (fr) | 1977-04-06 | 1977-12-07 | Nouveau procede pour la synthese de la 1-cyano-2-methyl-3-(2-<(-5-methyl-imidazol-4-yl)thio>ethyl)-guanidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES458042A ES458042A1 (es) | 1977-04-06 | 1977-04-06 | Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES458042A1 true ES458042A1 (es) | 1978-08-16 |
Family
ID=8473606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458042A Expired ES458042A1 (es) | 1977-04-06 | 1977-04-06 | Nuevo procedimiento para la sintesis de la 1-ciano-2-metil- 3-(2-(((5-metil-imidazol-4-il-)metil)tio)etil)-guanidina. |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES458042A1 (es) |
| FR (1) | FR2386525A1 (es) |
| PT (1) | PT67377B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI63753C (fi) * | 1980-08-21 | 1987-02-19 | Orion Yhtymae Oy | Foerfarande foer framstaellning av kristallint simetidin. |
| IT1215344B (it) * | 1987-01-27 | 1990-02-08 | Dessy S R L Ora Recordati Farm | Procedimento per la preparazione di composti ad attivita' anti-ulcera. |
| US5808090A (en) * | 1996-02-22 | 1998-09-15 | Endo Pharmaceuticals Inc. | Process for preventing precipitation in cimetidine injection solutions |
-
1977
- 1977-04-06 ES ES458042A patent/ES458042A1/es not_active Expired
- 1977-10-17 FR FR7732156A patent/FR2386525A1/fr not_active Withdrawn
- 1977-12-07 PT PT67377A patent/PT67377B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT67377A (fr) | 1978-01-01 |
| PT67377B (fr) | 1979-05-18 |
| FR2386525A1 (fr) | 1978-11-03 |
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