DE3132915A1 - 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3132915A1
DE3132915A1 DE19813132915 DE3132915A DE3132915A1 DE 3132915 A1 DE3132915 A1 DE 3132915A1 DE 19813132915 DE19813132915 DE 19813132915 DE 3132915 A DE3132915 A DE 3132915A DE 3132915 A1 DE3132915 A1 DE 3132915A1
Authority
DE
Germany
Prior art keywords
halogen
compounds
hydrogen
lower alkyl
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813132915
Other languages
German (de)
English (en)
Inventor
Henning Dipl.-Chem. Dr. 3000 Hannover Heinemann
Daniel Dr. 75018 Paris Jasserand
Wolfgang Dipl.-Chem. Dr. 3167 Burgdorf Milkowski
Dimitri Dr.med. 01400 Châtillon Chalaronne Yavordios
Horst Dipl.-Chem. Dr. 3000 Hannover Zeugner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to DE19813132915 priority Critical patent/DE3132915A1/de
Priority to ZA825381A priority patent/ZA825381B/xx
Priority to PT75353A priority patent/PT75353B/pt
Priority to AT82107193T priority patent/ATE43841T1/de
Priority to DE8282107193T priority patent/DE3279756D1/de
Priority to EP82107193A priority patent/EP0072960B1/de
Priority to CA000409072A priority patent/CA1208643A/en
Priority to DD82242578A priority patent/DD202563A5/de
Priority to GR69057A priority patent/GR76272B/el
Priority to PH27741A priority patent/PH19107A/en
Priority to GR69059A priority patent/GR78228B/el
Priority to HU822675A priority patent/HU187572B/hu
Priority to FI822883A priority patent/FI73673C/fi
Priority to IE2002/82A priority patent/IE55377B1/en
Priority to ES515107A priority patent/ES515107A0/es
Priority to US06/409,631 priority patent/US4442102A/en
Priority to AU87424/82A priority patent/AU555215B2/en
Priority to NZ201643A priority patent/NZ201643A/xx
Priority to DK372382A priority patent/DK149947C/da
Priority to NO822827A priority patent/NO158185C/no
Priority to IL66580A priority patent/IL66580A/xx
Priority to JP57143479A priority patent/JPS5839668A/ja
Publication of DE3132915A1 publication Critical patent/DE3132915A1/de
Priority to US06/564,399 priority patent/US4515944A/en
Priority to CA000488742A priority patent/CA1210763A/en
Priority to DK181086A priority patent/DK154834C/da
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19813132915 1981-08-20 1981-08-20 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE3132915A1 (de)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DE19813132915 DE3132915A1 (de) 1981-08-20 1981-08-20 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ZA825381A ZA825381B (en) 1981-08-20 1982-07-27 1,5-diphenylpyrazolin-3-one compounds method for preparing them,and pharmaceutical compositions containing these compounds
PT75353A PT75353B (en) 1981-08-20 1982-07-30 Process for the preparation of 1,5-diphenylpyrazolin-3-ona compounds useful as medicines and of the intermediate products thereof
AT82107193T ATE43841T1 (de) 1981-08-20 1982-08-09 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE8282107193T DE3279756D1 (en) 1981-08-20 1982-08-09 1,5-diphenylpyrazolin-3-one compounds, process and intermediates for their preparation and medicines containing these compounds
EP82107193A EP0072960B1 (de) 1981-08-20 1982-08-09 1,5-Diphenylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CA000409072A CA1208643A (en) 1981-08-20 1982-08-10 1,5-diphenyl-pyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing them
DD82242578A DD202563A5 (de) 1981-08-20 1982-08-17 Verfahren zur herstellung von 1,5-diphenylpyrazolin-3-on-verbindungen
GR69057A GR76272B (enExample) 1981-08-20 1982-08-18
PH27741A PH19107A (en) 1981-08-20 1982-08-18 1,5-diphenylpyrazolin-3-one compounds,method for preparing them and pharmaceutical compositions containing these compounds
GR69059A GR78228B (enExample) 1981-08-20 1982-08-18
HU822675A HU187572B (en) 1981-08-20 1982-08-18 Process for preparing 1,5-diphenyl-pyrazolin-3-one derivatives
NO822827A NO158185C (no) 1981-08-20 1982-08-19 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 1,5-difenylpyrazolin-3-on-forbindelser.
FI822883A FI73673C (fi) 1981-08-20 1982-08-19 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 1,5-difenylpyrazolin-3-on-foereningar.
ES515107A ES515107A0 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona".
US06/409,631 US4442102A (en) 1981-08-20 1982-08-19 1,5-Diphenylpyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing same
AU87424/82A AU555215B2 (en) 1981-08-20 1982-08-19 1,5-diphenylpyrazolin-3-one compounds
NZ201643A NZ201643A (en) 1981-08-20 1982-08-19 1,5-diphenylpyrazolin-3-ones and pharmaceutical compositions
DK372382A DK149947C (da) 1981-08-20 1982-08-19 Analogifremgangsmaade til fremstilling af 1,5-diphenylpyrazolin-3-on-forbindelser eller syreadditionssalte deraf
IE2002/82A IE55377B1 (en) 1981-08-20 1982-08-19 1,5-diphenylpyrazolin-3-one compounds,method for preparing them,and pharmaceutical compositions containing these compounds
IL66580A IL66580A (en) 1981-08-20 1982-08-19 1,5-diphenyl-2-piperazinylalkyl-pyrazolin-3-one compounds,their preparation and pharmaceutical compositions containing them
JP57143479A JPS5839668A (ja) 1981-08-20 1982-08-20 １，５−ジフエニルピラゾリン−３−オン化合物、その製造法及び該化合物を含有する、抗アレルギ−作用を有する医薬品
US06/564,399 US4515944A (en) 1981-08-20 1983-12-22 1,5-Diphenyl-2-haloalkylpyrazolin-3-one intermediates
CA000488742A CA1210763A (en) 1981-08-20 1985-08-14 1,5-diphenyl-pyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing them
DK181086A DK154834C (da) 1981-08-20 1986-04-21 1,5-diphenylpyrazolin-derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813132915 DE3132915A1 (de) 1981-08-20 1981-08-20 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE3132915A1 true DE3132915A1 (de) 1983-03-03

Family

ID=6139713

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19813132915 Withdrawn DE3132915A1 (de) 1981-08-20 1981-08-20 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE8282107193T Expired DE3279756D1 (en) 1981-08-20 1982-08-09 1,5-diphenylpyrazolin-3-one compounds, process and intermediates for their preparation and medicines containing these compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8282107193T Expired DE3279756D1 (en) 1981-08-20 1982-08-09 1,5-diphenylpyrazolin-3-one compounds, process and intermediates for their preparation and medicines containing these compounds

Country Status (20)

Country Link
US (2) US4442102A (enExample)
EP (1) EP0072960B1 (enExample)
JP (1) JPS5839668A (enExample)
AT (1) ATE43841T1 (enExample)
AU (1) AU555215B2 (enExample)
CA (1) CA1208643A (enExample)
DD (1) DD202563A5 (enExample)
DE (2) DE3132915A1 (enExample)
DK (1) DK149947C (enExample)
ES (1) ES515107A0 (enExample)
FI (1) FI73673C (enExample)
GR (2) GR76272B (enExample)
HU (1) HU187572B (enExample)
IE (1) IE55377B1 (enExample)
IL (1) IL66580A (enExample)
NO (1) NO158185C (enExample)
NZ (1) NZ201643A (enExample)
PH (1) PH19107A (enExample)
PT (1) PT75353B (enExample)
ZA (1) ZA825381B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3442860A1 (de) * 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US7589202B2 (en) * 2000-08-14 2009-09-15 Ortho Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
AU2005219438B2 (en) * 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
WO2011051958A1 (en) * 2009-10-30 2011-05-05 E.I. Du Pont De Nemours And Company Fungicidal pyrazolones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE66610C (de) * FARBWERKE VORM. MEISTER LUCIUS & BRÜNING in Höchst a. M Verfahren zur Darstellung von Oxaethylmethylphenylpyrazolon
DE74912C (enExample) *
GB666578A (en) * 1948-01-10 1952-02-13 Luxema Process for the preparation of derivatives of 1, 2, 3 substituted pyrazolones and derivatives obtained by this process
US3169966A (en) * 1961-01-24 1965-02-16 Ciba Geigy Corp Aminopyrazoles
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
DE2828529A1 (de) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel

Also Published As

Publication number Publication date
NO158185C (no) 1988-07-27
DK372382A (da) 1983-02-21
PT75353B (en) 1984-08-01
DD202563A5 (de) 1983-09-21
PH19107A (en) 1986-01-02
AU8742482A (en) 1983-02-24
ES8306143A1 (es) 1983-05-01
DE3279756D1 (en) 1989-07-13
FI73673C (fi) 1987-11-09
EP0072960B1 (de) 1989-06-07
FI822883A0 (fi) 1982-08-19
FI822883L (fi) 1983-02-21
NO158185B (no) 1988-04-18
GR76272B (enExample) 1984-08-04
ATE43841T1 (de) 1989-06-15
FI73673B (fi) 1987-07-31
IE822002L (en) 1983-02-20
DK149947B (da) 1986-11-03
NO822827L (no) 1983-02-21
GR78228B (enExample) 1984-09-26
IL66580A0 (en) 1982-12-31
PT75353A (en) 1982-08-01
IL66580A (en) 1985-10-31
ES515107A0 (es) 1983-05-01
US4442102A (en) 1984-04-10
JPH0375542B2 (enExample) 1991-12-02
ZA825381B (en) 1983-05-25
EP0072960A3 (en) 1984-03-07
US4515944A (en) 1985-05-07
AU555215B2 (en) 1986-09-18
HU187572B (en) 1986-01-28
CA1208643A (en) 1986-07-29
IE55377B1 (en) 1990-08-29
NZ201643A (en) 1985-04-30
JPS5839668A (ja) 1983-03-08
DK149947C (da) 1987-06-15
EP0072960A2 (de) 1983-03-02

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