ES8306143A1 - "procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona". - Google Patents

"procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona".

Info

Publication number
ES8306143A1
ES8306143A1 ES515107A ES515107A ES8306143A1 ES 8306143 A1 ES8306143 A1 ES 8306143A1 ES 515107 A ES515107 A ES 515107A ES 515107 A ES515107 A ES 515107A ES 8306143 A1 ES8306143 A1 ES 8306143A1
Authority
ES
Spain
Prior art keywords
radical
compounds
hydrogen
halogen atom
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515107A
Other languages
English (en)
Other versions
ES515107A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Publication of ES515107A0 publication Critical patent/ES515107A0/es
Publication of ES8306143A1 publication Critical patent/ES8306143A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 1,5-DIFENILPIRAZOLIN-3-ONA Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE Z ES ALCOHILENO C <- ; Y R , R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE COMPUESTOS DE FORMULA (II) O (III) CON COMPUESTOS DE FORMULA (IV), EN LAS QUE R -R Y Z TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y ES UN RADICAL SEPARABLE POR AMINOLISIS; Z ES UN ALCOHILENO C <- ; E Y ES HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN CONDICIONES BASICAS A TEMPERATURAS ENTRE LA AMBIENTE Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIALERGICOS E HIPONTENSORES
ES515107A 1981-08-20 1982-08-19 "procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona". Expired ES8306143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813132915 DE3132915A1 (de) 1981-08-20 1981-08-20 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES515107A0 ES515107A0 (es) 1983-05-01
ES8306143A1 true ES8306143A1 (es) 1983-05-01

Family

ID=6139713

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515107A Expired ES8306143A1 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de compuestos de 1,5-difenilpirazolin-3-ona".

Country Status (20)

Country Link
US (2) US4442102A (es)
EP (1) EP0072960B1 (es)
JP (1) JPS5839668A (es)
AT (1) ATE43841T1 (es)
AU (1) AU555215B2 (es)
CA (1) CA1208643A (es)
DD (1) DD202563A5 (es)
DE (2) DE3132915A1 (es)
DK (1) DK149947C (es)
ES (1) ES8306143A1 (es)
FI (1) FI73673C (es)
GR (2) GR78228B (es)
HU (1) HU187572B (es)
IE (1) IE55377B1 (es)
IL (1) IL66580A (es)
NO (1) NO158185C (es)
NZ (1) NZ201643A (es)
PH (1) PH19107A (es)
PT (1) PT75353B (es)
ZA (1) ZA825381B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3442860A1 (de) * 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
MXPA03001421A (es) * 2000-08-14 2004-01-26 Johnson & Johnson Pirazoles sustituidos.
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
DE60328690D1 (de) * 2002-06-12 2009-09-17 Chemocentryx Inc 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen
CA2558211C (en) * 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
WO2011051958A1 (en) * 2009-10-30 2011-05-05 E.I. Du Pont De Nemours And Company Fungicidal pyrazolones

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE66610C (de) * FARBWERKE VORM. MEISTER LUCIUS & BRÜNING in Höchst a. M Verfahren zur Darstellung von Oxaethylmethylphenylpyrazolon
DE74912C (es) *
GB666578A (en) * 1948-01-10 1952-02-13 Luxema Process for the preparation of derivatives of 1, 2, 3 substituted pyrazolones and derivatives obtained by this process
US3169966A (en) * 1961-01-24 1965-02-16 Ciba Geigy Corp Aminopyrazoles
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
DE2828529A1 (de) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel

Also Published As

Publication number Publication date
DK372382A (da) 1983-02-21
NO158185C (no) 1988-07-27
FI822883A0 (fi) 1982-08-19
PT75353B (en) 1984-08-01
AU8742482A (en) 1983-02-24
DK149947C (da) 1987-06-15
ES515107A0 (es) 1983-05-01
IL66580A (en) 1985-10-31
HU187572B (en) 1986-01-28
EP0072960B1 (de) 1989-06-07
NZ201643A (en) 1985-04-30
FI73673C (fi) 1987-11-09
ZA825381B (en) 1983-05-25
GR78228B (es) 1984-09-26
DE3279756D1 (en) 1989-07-13
JPS5839668A (ja) 1983-03-08
ATE43841T1 (de) 1989-06-15
US4515944A (en) 1985-05-07
EP0072960A3 (en) 1984-03-07
GR76272B (es) 1984-08-04
NO822827L (no) 1983-02-21
EP0072960A2 (de) 1983-03-02
IE55377B1 (en) 1990-08-29
FI822883L (fi) 1983-02-21
DD202563A5 (de) 1983-09-21
PT75353A (en) 1982-08-01
NO158185B (no) 1988-04-18
FI73673B (fi) 1987-07-31
IE822002L (en) 1983-02-20
US4442102A (en) 1984-04-10
AU555215B2 (en) 1986-09-18
IL66580A0 (en) 1982-12-31
DE3132915A1 (de) 1983-03-03
CA1208643A (en) 1986-07-29
DK149947B (da) 1986-11-03
PH19107A (en) 1986-01-02
JPH0375542B2 (es) 1991-12-02

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