DE3124719C2 - 10-(1,2-Propadienyl)-östr-4-en-3,17-dion, entsprechendes Zwischenprodukt und pharmazeutische Zubereitungen, die diese Verbindungen enthalten - Google Patents
10-(1,2-Propadienyl)-östr-4-en-3,17-dion, entsprechendes Zwischenprodukt und pharmazeutische Zubereitungen, die diese Verbindungen enthaltenInfo
- Publication number
- DE3124719C2 DE3124719C2 DE3124719A DE3124719A DE3124719C2 DE 3124719 C2 DE3124719 C2 DE 3124719C2 DE 3124719 A DE3124719 A DE 3124719A DE 3124719 A DE3124719 A DE 3124719A DE 3124719 C2 DE3124719 C2 DE 3124719C2
- Authority
- DE
- Germany
- Prior art keywords
- dione
- propadienyl
- compounds
- enzyme
- ene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/163,453 US4289762A (en) | 1980-06-27 | 1980-06-27 | 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3124719A1 DE3124719A1 (de) | 1982-03-18 |
| DE3124719C2 true DE3124719C2 (de) | 1994-03-03 |
Family
ID=22590073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3124719A Expired - Fee Related DE3124719C2 (de) | 1980-06-27 | 1981-06-24 | 10-(1,2-Propadienyl)-östr-4-en-3,17-dion, entsprechendes Zwischenprodukt und pharmazeutische Zubereitungen, die diese Verbindungen enthalten |
Country Status (21)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3362176D1 (en) * | 1982-07-14 | 1986-03-27 | Akzo Nv | Novel 19-thio-androstane derivatives |
| US4495102A (en) * | 1982-09-03 | 1985-01-22 | G. D. Searle & Co. | Aminoalkyl steroids |
| DE3378208D1 (en) * | 1982-12-21 | 1988-11-17 | Ciba Geigy Ag | Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds |
| DE3323321A1 (de) * | 1983-06-24 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels |
| US4634694A (en) * | 1984-01-14 | 1987-01-06 | Akzo N.V. | Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives |
| GB8531747D0 (en) * | 1985-12-24 | 1986-02-05 | Erba Farmitalia | 10beta-alkynylestrene derivatives |
| GB8624251D0 (en) * | 1986-10-09 | 1986-11-12 | Erba Farmitalia | "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives |
| DE3705990A1 (de) * | 1987-02-20 | 1988-09-01 | Schering Ag | 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3714965A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US4910191A (en) * | 1988-06-28 | 1990-03-20 | Merrell Dow Pharmaceuticals Inc. | 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors |
| CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| CN100576306C (zh) | 1995-02-01 | 2009-12-30 | 精工爱普生株式会社 | 液晶显示装置 |
| DE60220516T2 (de) * | 2001-04-17 | 2007-10-11 | Ares Trading S.A. | Aromatasehemmung zum Verbessern assistierter Reproduktion |
| DE10141937A1 (de) * | 2001-08-28 | 2003-03-27 | Alfred Schmidt | Markierung der Aromatase |
| EP1854465A1 (en) * | 2006-05-12 | 2007-11-14 | Alexander Tobias Teichmann | Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers |
| CA2794565C (en) | 2010-04-08 | 2018-08-21 | Emory University | Substituted androst-4-ene diones |
| EP3666276A1 (en) | 2018-12-14 | 2020-06-17 | dcic Biopharmaceutical Limited | Medication against estrogen-receptor beta (erbeta) positive breast tumor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3102127A (en) * | 1962-06-12 | 1963-08-27 | Syntex Corp | 19-methylene-androstane derivatives |
| FR1519387A (fr) * | 1966-04-20 | 1968-03-29 | Hoffmann La Roche | Procédé pour la préparation de 19-alcényl-stéroïdes |
| DE2310963A1 (de) * | 1972-04-14 | 1974-09-05 | Schering Ag | Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten |
| CH606101A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1975-01-30 | 1978-10-13 | Ciba Geigy Ag |
-
1980
- 1980-06-27 US US06/163,453 patent/US4289762A/en not_active Expired - Lifetime
-
1981
- 1981-06-22 NZ NZ197495A patent/NZ197495A/en unknown
- 1981-06-22 IL IL63142A patent/IL63142A0/xx not_active IP Right Cessation
- 1981-06-22 CA CA000380342A patent/CA1173432A/en not_active Expired
- 1981-06-22 PH PH25799A patent/PH16690A/en unknown
- 1981-06-22 ZA ZA814219A patent/ZA814219B/xx unknown
- 1981-06-24 DE DE3124719A patent/DE3124719C2/de not_active Expired - Fee Related
- 1981-06-25 SE SE8103988A patent/SE448878B/sv not_active IP Right Cessation
- 1981-06-25 CH CH4213/81A patent/CH647532A5/de not_active IP Right Cessation
- 1981-06-26 DK DK284481A patent/DK163129C/da not_active IP Right Cessation
- 1981-06-26 IE IE1435/81A patent/IE51352B1/en not_active IP Right Cessation
- 1981-06-26 FR FR8112643A patent/FR2485544A1/fr active Granted
- 1981-06-26 GB GB8119814A patent/GB2078750B/en not_active Expired
- 1981-06-26 ES ES503451A patent/ES503451A0/es active Granted
- 1981-06-26 BE BE0/205232A patent/BE889404A/fr not_active IP Right Cessation
- 1981-06-26 NL NL8103098A patent/NL8103098A/nl not_active Application Discontinuation
- 1981-06-26 IT IT8148781A patent/IT1171340B/it active
- 1981-06-26 AT AT0285881A patent/AT377989B/de not_active IP Right Cessation
- 1981-06-27 JP JP9909781A patent/JPS5738798A/ja active Granted
- 1981-06-30 AU AU72369/81A patent/AU539215B2/en not_active Ceased
- 1981-07-22 NO NO81812509A patent/NO156694C/no unknown
Also Published As
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| Publication | Publication Date | Title |
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