DE69126622T2 - 2beta,19-methylenamin überbrückte steroide als aromatasehemmer - Google Patents

2beta,19-methylenamin überbrückte steroide als aromatasehemmer

Info

Publication number
DE69126622T2
DE69126622T2 DE69126622T DE69126622T DE69126622T2 DE 69126622 T2 DE69126622 T2 DE 69126622T2 DE 69126622 T DE69126622 T DE 69126622T DE 69126622 T DE69126622 T DE 69126622T DE 69126622 T2 DE69126622 T2 DE 69126622T2
Authority
DE
Germany
Prior art keywords
aromatase inhibitors
methylenamine
2beta
bridged steroids
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126622T
Other languages
English (en)
Other versions
DE69126622D1 (de
Inventor
J Johnston
Norton Peet
Joseph Burkhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69126622D1 publication Critical patent/DE69126622D1/de
Application granted granted Critical
Publication of DE69126622T2 publication Critical patent/DE69126622T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69126622T 1990-11-30 1991-11-17 2beta,19-methylenamin überbrückte steroide als aromatasehemmer Expired - Fee Related DE69126622T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/621,183 US5126488A (en) 1990-11-30 1990-11-30 2β,19-methyleneamino bridged steroids as aromatase inhibitors
PCT/US1991/007810 WO1992009619A1 (en) 1990-11-30 1991-11-17 2β,19-METHYLENEAMINO BRIDGED STEROIDS AS AROMATASE INHIBITORS

Publications (2)

Publication Number Publication Date
DE69126622D1 DE69126622D1 (de) 1997-07-24
DE69126622T2 true DE69126622T2 (de) 1997-10-23

Family

ID=24489088

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126622T Expired - Fee Related DE69126622T2 (de) 1990-11-30 1991-11-17 2beta,19-methylenamin überbrückte steroide als aromatasehemmer

Country Status (15)

Country Link
US (1) US5126488A (de)
EP (1) EP0559706B1 (de)
JP (1) JP3021651B2 (de)
KR (1) KR100200462B1 (de)
AT (1) ATE154606T1 (de)
AU (1) AU647226B2 (de)
CA (1) CA2096020C (de)
DE (1) DE69126622T2 (de)
DK (1) DK0559706T3 (de)
ES (1) ES2104736T3 (de)
FI (1) FI932446A0 (de)
GR (1) GR3024298T3 (de)
HU (1) HU213608B (de)
NO (1) NO302123B1 (de)
WO (1) WO1992009619A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510340A (en) * 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
EP3827747A1 (de) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharmainformatiksystem
EP1945240B1 (de) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
IL295075A (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
AU630008B2 (en) * 1989-12-20 1992-10-15 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors

Also Published As

Publication number Publication date
DE69126622D1 (de) 1997-07-24
EP0559706B1 (de) 1997-06-18
HUT64365A (en) 1993-12-28
FI932446A (fi) 1993-05-28
ATE154606T1 (de) 1997-07-15
GR3024298T3 (en) 1997-10-31
CA2096020A1 (en) 1992-05-31
DK0559706T3 (da) 1997-09-08
ES2104736T3 (es) 1997-10-16
EP0559706A4 (de) 1994-02-09
AU647226B2 (en) 1994-03-17
WO1992009619A1 (en) 1992-06-11
CA2096020C (en) 2003-06-17
FI932446A0 (fi) 1993-05-28
KR100200462B1 (ko) 1999-06-15
NO931951L (no) 1993-05-28
JPH06509543A (ja) 1994-10-27
HU213608B (en) 1997-08-28
EP0559706A1 (de) 1993-09-15
NO931951D0 (no) 1993-05-28
US5126488A (en) 1992-06-30
AU9027991A (en) 1992-06-25
JP3021651B2 (ja) 2000-03-15
NO302123B1 (no) 1998-01-26

Similar Documents

Publication Publication Date Title
DE69634039D1 (de) Neuroaktive steroide der androstan- und pregnanreihe
SE8603046D0 (sv) Substituted androsta-1,4-diene-3,17-diones and process for their preparation
DK0582338T3 (da) 17-spiromethylensteroider
NO842408L (no) Fremgangsmaate ved fremstilling av 1-alkyl-androsta-1,4-dien-3,17-dioner
DE69126622D1 (de) 2beta,19-methylenamin überbrückte steroide als aromatasehemmer
DE68911157T2 (de) Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate.
ATE152119T1 (de) Neue 16-methyl substituierte steroidderivate von pregna-1,4-dien-3,20-dion, ihre herstellung, ihre verwendung zur herstellung von 16-methylene- substituierte steroide und neue zwischenprodukten dafür
ATE142639T1 (de) 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren
ATE277071T1 (de) Durch 11-beta-aryl-17,17-spirothiolan substituierte steroide

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee