ES2104736T3 - Esteroides con puente de 2beta,19-metileno-amino utilizados como inhibidores de aromatasa. - Google Patents

Esteroides con puente de 2beta,19-metileno-amino utilizados como inhibidores de aromatasa.

Info

Publication number
ES2104736T3
ES2104736T3 ES91920606T ES91920606T ES2104736T3 ES 2104736 T3 ES2104736 T3 ES 2104736T3 ES 91920606 T ES91920606 T ES 91920606T ES 91920606 T ES91920606 T ES 91920606T ES 2104736 T3 ES2104736 T3 ES 2104736T3
Authority
ES
Spain
Prior art keywords
aromatase inhibitors
2beta
methylene
amino used
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920606T
Other languages
English (en)
Inventor
J O'neal Johnston
Norton P Peet
Joseph P Burkhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2104736T3 publication Critical patent/ES2104736T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA 2(BETA),19(METILENAMINO)ANDROST-4-ENO-3,17-DIONA Y AL 17(BETA)-OL CORRESPONDIENTE QUE SON UTILES COMO INHIBIDORES DE LA AROMATASA. LOS COMPUESTOS SE PREPARAN MEDIANTE LA CICLACION DE UN (2METOXIETOXI)METILAMINO-ESTEROIDE PROTEGIDO EN LA POSICION 19-N UTILIZANDO TETRACLORURO DE TITANIO SEGUIDO DE UNA REDUCCION SELECTIVA, SI SE DESEA, DE LA 17-CETONA.
ES91920606T 1990-11-30 1991-10-17 Esteroides con puente de 2beta,19-metileno-amino utilizados como inhibidores de aromatasa. Expired - Lifetime ES2104736T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/621,183 US5126488A (en) 1990-11-30 1990-11-30 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Publications (1)

Publication Number Publication Date
ES2104736T3 true ES2104736T3 (es) 1997-10-16

Family

ID=24489088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920606T Expired - Lifetime ES2104736T3 (es) 1990-11-30 1991-10-17 Esteroides con puente de 2beta,19-metileno-amino utilizados como inhibidores de aromatasa.

Country Status (15)

Country Link
US (1) US5126488A (es)
EP (1) EP0559706B1 (es)
JP (1) JP3021651B2 (es)
KR (1) KR100200462B1 (es)
AT (1) ATE154606T1 (es)
AU (1) AU647226B2 (es)
CA (1) CA2096020C (es)
DE (1) DE69126622T2 (es)
DK (1) DK0559706T3 (es)
ES (1) ES2104736T3 (es)
FI (1) FI932446A (es)
GR (1) GR3024298T3 (es)
HU (1) HU213608B (es)
NO (1) NO302123B1 (es)
WO (1) WO1992009619A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510340A (en) * 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
NZ236473A (en) * 1989-12-20 1993-04-28 Merrell Dow Pharma 2,19-methyleneoxy and 2,19-methylenethio bridged steroids and pharmaceutical compositions

Also Published As

Publication number Publication date
KR100200462B1 (ko) 1999-06-15
AU9027991A (en) 1992-06-25
CA2096020A1 (en) 1992-05-31
AU647226B2 (en) 1994-03-17
HUT64365A (en) 1993-12-28
JP3021651B2 (ja) 2000-03-15
ATE154606T1 (de) 1997-07-15
EP0559706A1 (en) 1993-09-15
NO931951L (no) 1993-05-28
DE69126622D1 (de) 1997-07-24
EP0559706B1 (en) 1997-06-18
FI932446A0 (fi) 1993-05-28
DE69126622T2 (de) 1997-10-23
HU213608B (en) 1997-08-28
NO302123B1 (no) 1998-01-26
JPH06509543A (ja) 1994-10-27
EP0559706A4 (es) 1994-02-09
WO1992009619A1 (en) 1992-06-11
NO931951D0 (no) 1993-05-28
FI932446A (fi) 1993-05-28
GR3024298T3 (en) 1997-10-31
CA2096020C (en) 2003-06-17
US5126488A (en) 1992-06-30
DK0559706T3 (da) 1997-09-08

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