ATE142639T1 - 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren - Google Patents

2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren

Info

Publication number
ATE142639T1
ATE142639T1 AT91120560T AT91120560T ATE142639T1 AT E142639 T1 ATE142639 T1 AT E142639T1 AT 91120560 T AT91120560 T AT 91120560T AT 91120560 T AT91120560 T AT 91120560T AT E142639 T1 ATE142639 T1 AT E142639T1
Authority
AT
Austria
Prior art keywords
aromatase inhibitors
ethylene
beta
bridged steroids
steroids
Prior art date
Application number
AT91120560T
Other languages
English (en)
Inventor
J O'neal Johnston
Norton P Peet
Joseph P Burkhart
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE142639T1 publication Critical patent/ATE142639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
AT91120560T 1990-11-30 1991-11-29 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren ATE142639T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/621,184 US5166201A (en) 1990-11-30 1990-11-30 2β,19-ethylene bridged steroids as aromatase inhibitors

Publications (1)

Publication Number Publication Date
ATE142639T1 true ATE142639T1 (de) 1996-09-15

Family

ID=24489093

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91120560T ATE142639T1 (de) 1990-11-30 1991-11-29 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren

Country Status (20)

Country Link
US (1) US5166201A (de)
EP (1) EP0488383B1 (de)
JP (1) JP3143876B2 (de)
KR (1) KR100190776B1 (de)
CN (1) CN1033975C (de)
AT (1) ATE142639T1 (de)
AU (1) AU635444B2 (de)
CA (1) CA2056638C (de)
DE (1) DE69122048T2 (de)
DK (1) DK0488383T3 (de)
ES (1) ES2094183T3 (de)
FI (1) FI102073B (de)
GR (1) GR3021981T3 (de)
HU (1) HU210830B (de)
IE (1) IE914168A1 (de)
IL (1) IL100196A (de)
NO (1) NO180304C (de)
NZ (1) NZ240738A (de)
PT (1) PT99661B (de)
ZA (1) ZA919296B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510862A1 (de) * 1995-03-16 1996-09-19 Schering Ag Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
GB8501035D0 (en) * 1985-01-16 1985-02-20 Senior J Prostaglandins
US4882322A (en) * 1988-10-27 1989-11-21 Merrell Dow Pharmaceuticals Inc. 3β,17β-hydroxy-substituted steroids and related steroidal compounds

Also Published As

Publication number Publication date
CN1033975C (zh) 1997-02-05
FI915623A0 (fi) 1991-11-28
AU635444B2 (en) 1993-03-18
DK0488383T3 (da) 1996-09-30
FI102073B1 (fi) 1998-10-15
NO180304B (no) 1996-12-16
CA2056638A1 (en) 1992-05-31
ZA919296B (en) 1992-08-26
NO914710D0 (no) 1991-11-29
FI102073B (fi) 1998-10-15
PT99661B (pt) 1999-05-31
JP3143876B2 (ja) 2001-03-07
US5166201A (en) 1992-11-24
EP0488383A1 (de) 1992-06-03
HU913739D0 (en) 1992-02-28
HU210830B (en) 1995-08-28
NO914710L (no) 1992-06-01
IL100196A0 (en) 1992-08-18
DE69122048T2 (de) 1997-02-20
FI915623A (fi) 1992-05-31
KR920009842A (ko) 1992-06-25
IL100196A (en) 1996-03-31
NZ240738A (en) 1993-11-25
KR100190776B1 (ko) 1999-06-01
HUT59937A (en) 1992-07-28
ES2094183T3 (es) 1997-01-16
PT99661A (pt) 1992-10-30
IE914168A1 (en) 1992-06-03
CA2056638C (en) 2002-03-05
GR3021981T3 (en) 1997-03-31
CN1061974A (zh) 1992-06-17
DE69122048D1 (de) 1996-10-17
AU8812891A (en) 1992-06-04
NO180304C (no) 1997-04-02
EP0488383B1 (de) 1996-09-11
JPH04290898A (ja) 1992-10-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee