DK163129C - Analogifremgangsmaade til fremstilling af 10-(1,2-propadienyl)-steroider - Google Patents

Analogifremgangsmaade til fremstilling af 10-(1,2-propadienyl)-steroider

Info

Publication number
DK163129C
DK163129C DK284481A DK284481A DK163129C DK 163129 C DK163129 C DK 163129C DK 284481 A DK284481 A DK 284481A DK 284481 A DK284481 A DK 284481A DK 163129 C DK163129 C DK 163129C
Authority
DK
Denmark
Prior art keywords
propadienyl
steroids
analogue
preparation
Prior art date
Application number
DK284481A
Other languages
English (en)
Other versions
DK284481A (da
DK163129B (da
Inventor
Brian W Metcalf
J O'neal Johnston
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK284481A publication Critical patent/DK284481A/da
Publication of DK163129B publication Critical patent/DK163129B/da
Application granted granted Critical
Publication of DK163129C publication Critical patent/DK163129C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK284481A 1980-06-27 1981-06-26 Analogifremgangsmaade til fremstilling af 10-(1,2-propadienyl)-steroider DK163129C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16345380 1980-06-27
US06/163,453 US4289762A (en) 1980-06-27 1980-06-27 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors

Publications (3)

Publication Number Publication Date
DK284481A DK284481A (da) 1981-12-28
DK163129B DK163129B (da) 1992-01-20
DK163129C true DK163129C (da) 1992-06-09

Family

ID=22590073

Family Applications (1)

Application Number Title Priority Date Filing Date
DK284481A DK163129C (da) 1980-06-27 1981-06-26 Analogifremgangsmaade til fremstilling af 10-(1,2-propadienyl)-steroider

Country Status (21)

Country Link
US (1) US4289762A (da)
JP (1) JPS5738798A (da)
AT (1) AT377989B (da)
AU (1) AU539215B2 (da)
BE (1) BE889404A (da)
CA (1) CA1173432A (da)
CH (1) CH647532A5 (da)
DE (1) DE3124719C2 (da)
DK (1) DK163129C (da)
ES (1) ES8400449A1 (da)
FR (1) FR2485544A1 (da)
GB (1) GB2078750B (da)
IE (1) IE51352B1 (da)
IL (1) IL63142A0 (da)
IT (1) IT1171340B (da)
NL (1) NL8103098A (da)
NO (1) NO156694C (da)
NZ (1) NZ197495A (da)
PH (1) PH16690A (da)
SE (1) SE448878B (da)
ZA (1) ZA814219B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100566B1 (en) * 1982-07-14 1986-02-19 Akzo N.V. Novel 19-thio-androstane derivatives
US4495102A (en) * 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
EP0114033B1 (de) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Substituierte Azabicycloalkane, ihre Verwendung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verfahren zur Herstellung dieser Verbindungen
DE3323321A1 (de) * 1983-06-24 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
US4634694A (en) * 1984-01-14 1987-01-06 Akzo N.V. Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
EP1708169A1 (en) 1995-02-01 2006-10-04 Seiko Epson Corporation Driving circuit and active matrix substrate and liquid crystal display device including it
PL366554A1 (en) * 2001-04-17 2005-02-07 Ares Trading S.A. Aromatase inhibition to enhance assisted reproduction
DE10141937A1 (de) * 2001-08-28 2003-03-27 Alfred Schmidt Markierung der Aromatase
EP1854465A1 (en) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
WO2011127232A2 (en) 2010-04-08 2011-10-13 Emory University Substituted androst-4-ene diones
EP3666276A1 (en) 2018-12-14 2020-06-17 dcic Biopharmaceutical Limited Medication against estrogen-receptor beta (erbeta) positive breast tumor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102127A (en) * 1962-06-12 1963-08-27 Syntex Corp 19-methylene-androstane derivatives
FR1519387A (fr) * 1966-04-20 1968-03-29 Hoffmann La Roche Procédé pour la préparation de 19-alcényl-stéroïdes
DE2310963A1 (de) * 1972-04-14 1974-09-05 Schering Ag Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten
CH606101A5 (da) * 1975-01-30 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
IE811435L (en) 1981-12-27
AT377989B (de) 1985-05-28
DE3124719A1 (de) 1982-03-18
US4289762A (en) 1981-09-15
JPS5738798A (en) 1982-03-03
DK284481A (da) 1981-12-28
ATA285881A (de) 1984-10-15
PH16690A (en) 1984-01-06
AU539215B2 (en) 1984-09-13
ZA814219B (en) 1982-07-28
NO812509L (no) 1983-01-24
ES503451A0 (es) 1983-11-01
IT8148781A0 (it) 1981-06-26
SE448878B (sv) 1987-03-23
AU7236981A (en) 1982-01-07
DE3124719C2 (de) 1994-03-03
ES8400449A1 (es) 1983-11-01
CH647532A5 (de) 1985-01-31
GB2078750A (en) 1982-01-13
FR2485544A1 (fr) 1981-12-31
IE51352B1 (en) 1986-12-10
CA1173432A (en) 1984-08-28
GB2078750B (en) 1984-08-22
NL8103098A (nl) 1982-01-18
NO156694B (no) 1987-07-27
IL63142A0 (en) 1981-09-13
NO156694C (no) 1987-11-04
DK163129B (da) 1992-01-20
JPH0121158B2 (da) 1989-04-19
SE8103988L (sv) 1981-12-28
BE889404A (fr) 1981-12-28
NZ197495A (en) 1985-01-31
IT1171340B (it) 1987-06-10
FR2485544B1 (da) 1983-12-16

Similar Documents

Publication Publication Date Title
DK160866C (da) Analogifremgangsmaade til fremstilling af phenoletherforbindelser
DK155665C (da) Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
DK162601C (da) Analogifremgangsmaade til fremstilling af 8-oe4-oe4-(2,1-benzisothiazol-3-yl)-1-piperazinylaabutylaa-8-azaspirooe4.5aadecan-7,9-dion
DK155048C (da) Analogifremgangsmaade til fremstilling af 1,8-naphthyridinforbindelser
DK161333C (da) Analogifremgangsmaade til fremstilling af 11beta-substituerede 4,9-dien-steroider
DK156001C (da) Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner
DK157851C (da) Analogifremgangsmaade til fremstilling af en octa-hydro-1-(omega-mercaptoalkanoyl)-1h-indol-2-carboxylsyreforbindelse
DK153787C (da) Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
DK99781A (da) Fremgangsmaade til fremstilling af carboxtyrilderivater
DK152287C (da) Analogifremgangsmaade til fremstilling af carbostyril-derivater
DK528982A (da) Fremgangsmaade til fremstilling af 13,14-didehydro-prostaglandiner
DK163129C (da) Analogifremgangsmaade til fremstilling af 10-(1,2-propadienyl)-steroider
DK158269C (da) Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater
DK161581A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK157193C (da) Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
ES514633A0 (es) "metodo de preparar compuestos esteroidicos antiinflamatorios".
DK149846C (da) Analogifremgangsmaade til fremstilling af n,n'-bis-tetrahydro-isoquinolyldisulfonylimider
DK100281A (da) Fremgangsmaade til fremstilling af imidazolderivater
DK520781A (da) Fremgangsmaade til fremstilling af derivater af 5,6,7,7a-tetrahydro-4h-thieno (3,2-c)pyridin2-on
DK117779A (da) Fremgangsmaade til fremstilling af 2,6-dialkoxybenzamider
DK165741C (da) Analogifremgangsmaade til fremstilling af 3-phenoxy-1-azetidincarboxamider
DK158460C (da) Analogifremgangsmaade til fremstilling af substituerede oxocarboxylsyrer
DK173379A (da) Fremgangsmaade til fremstilling af 6alfa-halogen-3-keto-delta 1,4-pregnadienderivater
DK172181A (da) Fremgangsmaade til fremstilling af 9-carbamoyl-9-aminoalkylfluoren-derivater
DK188181A (da) Fremgangsmaade til fremstilling af halogenerede steroider

Legal Events

Date Code Title Description
PBP Patent lapsed