BE889404A - (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides - Google Patents

(propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides

Info

Publication number
BE889404A
BE889404A BE0/205232A BE205232A BE889404A BE 889404 A BE889404 A BE 889404A BE 0/205232 A BE0/205232 A BE 0/205232A BE 205232 A BE205232 A BE 205232A BE 889404 A BE889404 A BE 889404A
Authority
BE
Belgium
Prior art keywords
preparation
steroids
propadiene
intermediates
aromatase inhibitor
Prior art date
Application number
BE0/205232A
Other languages
English (en)
Inventor
Brian W Metcalf
J O Neal Johnston
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of BE889404A publication Critical patent/BE889404A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/205232A 1980-06-27 1981-06-26 (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides BE889404A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/163,453 US4289762A (en) 1980-06-27 1980-06-27 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors

Publications (1)

Publication Number Publication Date
BE889404A true BE889404A (fr) 1981-12-28

Family

ID=22590073

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/205232A BE889404A (fr) 1980-06-27 1981-06-26 (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides

Country Status (21)

Country Link
US (1) US4289762A (fr)
JP (1) JPS5738798A (fr)
AT (1) AT377989B (fr)
AU (1) AU539215B2 (fr)
BE (1) BE889404A (fr)
CA (1) CA1173432A (fr)
CH (1) CH647532A5 (fr)
DE (1) DE3124719C2 (fr)
DK (1) DK163129C (fr)
ES (1) ES503451A0 (fr)
FR (1) FR2485544A1 (fr)
GB (1) GB2078750B (fr)
IE (1) IE51352B1 (fr)
IL (1) IL63142A0 (fr)
IT (1) IT1171340B (fr)
NL (1) NL8103098A (fr)
NO (1) NO156694C (fr)
NZ (1) NZ197495A (fr)
PH (1) PH16690A (fr)
SE (1) SE448878B (fr)
ZA (1) ZA814219B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100566B1 (fr) * 1982-07-14 1986-02-19 Akzo N.V. Dérivés du 19-thioandrostane
US4495102A (en) * 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
EP0114033B1 (fr) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Azabicycloalcanes substitués, leur utilisation, préparations pharmaceutiques contenant ces composés et procédé pour la préparation de ces composés
DE3323321A1 (de) * 1983-06-24 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels
US4634694A (en) * 1984-01-14 1987-01-06 Akzo N.V. Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives
GB8531747D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynylestrene derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3714965A1 (de) * 1987-04-30 1988-11-10 Schering Ag 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
EP1603110A3 (fr) 1995-02-01 2006-01-04 Seiko Epson Corporation Substrat à matrice active et dispositf d'affichage à cristaux liquide avec le même
KR20040012751A (ko) * 2001-04-17 2004-02-11 아레스 트레이딩 에스.에이. 보조 생식을 고양하기 위한 아로마타제 저해
DE10141937A1 (de) * 2001-08-28 2003-03-27 Alfred Schmidt Markierung der Aromatase
EP1854465A1 (fr) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Utilisation du 4,17 béta-dihydroxyandrost-4-ene-3-one pour traiter les cancers
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
EP3666276A1 (fr) 2018-12-14 2020-06-17 dcic Biopharmaceutical Limited Médicament contre la tumeur positive du récepteur d'oestrogene beta (erbeta)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102127A (en) * 1962-06-12 1963-08-27 Syntex Corp 19-methylene-androstane derivatives
FR1519387A (fr) * 1966-04-20 1968-03-29 Hoffmann La Roche Procédé pour la préparation de 19-alcényl-stéroïdes
DE2310963A1 (de) * 1972-04-14 1974-09-05 Schering Ag Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten
CH606101A5 (fr) * 1975-01-30 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
AU539215B2 (en) 1984-09-13
IE51352B1 (en) 1986-12-10
SE448878B (sv) 1987-03-23
AT377989B (de) 1985-05-28
JPH0121158B2 (fr) 1989-04-19
GB2078750B (en) 1984-08-22
US4289762A (en) 1981-09-15
NL8103098A (nl) 1982-01-18
DK284481A (da) 1981-12-28
FR2485544A1 (fr) 1981-12-31
IT8148781A0 (it) 1981-06-26
FR2485544B1 (fr) 1983-12-16
DE3124719C2 (de) 1994-03-03
NO156694B (no) 1987-07-27
CA1173432A (fr) 1984-08-28
SE8103988L (sv) 1981-12-28
IT1171340B (it) 1987-06-10
AU7236981A (en) 1982-01-07
ZA814219B (en) 1982-07-28
CH647532A5 (de) 1985-01-31
ATA285881A (de) 1984-10-15
NO156694C (no) 1987-11-04
PH16690A (en) 1984-01-06
IL63142A0 (en) 1981-09-13
DK163129C (da) 1992-06-09
NZ197495A (en) 1985-01-31
NO812509L (no) 1983-01-24
IE811435L (en) 1981-12-27
ES8400449A1 (es) 1983-11-01
DK163129B (da) 1992-01-20
GB2078750A (en) 1982-01-13
ES503451A0 (es) 1983-11-01
DE3124719A1 (de) 1982-03-18
JPS5738798A (en) 1982-03-03

Similar Documents

Publication Publication Date Title
BE889404A (fr) (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides
FR2456767B1 (fr) Composition de silicone pour revetement pelable
BE863773A (fr) Composition pour le conditionnement des etoffes
FI813034L (fi) Foerfarande foer framstaellning av substituerade imino-disyror
FI823299L (fi) Anordning foer upphoejning av bukter i golven
FI834057A0 (fi) Anordning foer ytbelaeggning av roerliga materialbanor
IT1171339B (it) Composti inibitori dell'enzima aromatasi e procedimento per la loro preparazione
FI813279L (fi) Foerfarande foer framstaellning av azabicyklo-oktan-karbolxylsyror
ES506228A0 (es) Procedimiento para la preparacion de nuevos benzo (b) tiofe-nos
NO814065L (no) Fremgansmaate for fremstilling av imidazolylfenylamidiner
MA19985A1 (fr) Procedes pour la preparation de phenylsulfonyloxybenzimidazol carbaminates substitues et utilisation de ceux-ci comme medicaments
GB2039311B (en) Transportable bridge having means for folding the spans of the bridge
NO820281L (no) Fremgangsmaate ved fremstilling av n-(halogenmethyl)-acylamider
ES524796A0 (es) Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
DK136383A (da) Apparat til bestemmelse af aegloesning hos kvinder
ES487148A0 (es) Procedimiento de preparacion de nuevas trifluoroetilaminas n-sustituidas
YU188279A (en) Construction for bridging connections at bridges or similar constructions
NO814074L (no) Fremgangsmaate ved fremstilling av n-(halogenmethyl)-acylamider
RO81516A (fr) Composition sinergetique pour la destruction des poux
ATA25681A (de) Innenauskleidung von rohrkugelmuehlen
JPS5469231A (en) Main girder for bridge
FI813798L (fi) Foerfarande foer avlaegsnande av en belaeggning av antrakinon
NO813063L (no) Fremgangsmaate for fremstilling av 4-karbamoyloksyoksaza-fosforiner
JPS5673708A (en) Delivery device for bridge girder
IT1143063B (it) Composizione refrattaria per il rivestimento ed il restauro dei canali di colata di altiforni

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.

Effective date: 19940630