BE889404A - (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides - Google Patents
(propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroidesInfo
- Publication number
- BE889404A BE889404A BE0/205232A BE205232A BE889404A BE 889404 A BE889404 A BE 889404A BE 0/205232 A BE0/205232 A BE 0/205232A BE 205232 A BE205232 A BE 205232A BE 889404 A BE889404 A BE 889404A
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- steroids
- propadiene
- intermediates
- aromatase inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/163,453 US4289762A (en) | 1980-06-27 | 1980-06-27 | 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BE889404A true BE889404A (fr) | 1981-12-28 |
Family
ID=22590073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/205232A BE889404A (fr) | 1980-06-27 | 1981-06-26 | (propadiene-1,2 yl)-10 steroides inhibiteurs irreversibles des aromatases, leur preparation et leur utilisation, et intermediaires pour la preparation de ces steroides |
Country Status (21)
Country | Link |
---|---|
US (1) | US4289762A (fr) |
JP (1) | JPS5738798A (fr) |
AT (1) | AT377989B (fr) |
AU (1) | AU539215B2 (fr) |
BE (1) | BE889404A (fr) |
CA (1) | CA1173432A (fr) |
CH (1) | CH647532A5 (fr) |
DE (1) | DE3124719C2 (fr) |
DK (1) | DK163129C (fr) |
ES (1) | ES503451A0 (fr) |
FR (1) | FR2485544A1 (fr) |
GB (1) | GB2078750B (fr) |
IE (1) | IE51352B1 (fr) |
IL (1) | IL63142A0 (fr) |
IT (1) | IT1171340B (fr) |
NL (1) | NL8103098A (fr) |
NO (1) | NO156694C (fr) |
NZ (1) | NZ197495A (fr) |
PH (1) | PH16690A (fr) |
SE (1) | SE448878B (fr) |
ZA (1) | ZA814219B (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0100566B1 (fr) * | 1982-07-14 | 1986-02-19 | Akzo N.V. | Dérivés du 19-thioandrostane |
US4495102A (en) * | 1982-09-03 | 1985-01-22 | G. D. Searle & Co. | Aminoalkyl steroids |
EP0114033B1 (fr) * | 1982-12-21 | 1988-10-12 | Ciba-Geigy Ag | Azabicycloalcanes substitués, leur utilisation, préparations pharmaceutiques contenant ces composés et procédé pour la préparation de ces composés |
DE3323321A1 (de) * | 1983-06-24 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prophylaxe und therapie von koronaren herzkrankheiten durch senkung des oestrogenspiegels |
US4634694A (en) * | 1984-01-14 | 1987-01-06 | Akzo N.V. | Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives |
GB8531747D0 (en) * | 1985-12-24 | 1986-02-05 | Erba Farmitalia | 10beta-alkynylestrene derivatives |
GB8624251D0 (en) * | 1986-10-09 | 1986-11-12 | Erba Farmitalia | "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives |
DE3705990A1 (de) * | 1987-02-20 | 1988-09-01 | Schering Ag | 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3714965A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
US4910191A (en) * | 1988-06-28 | 1990-03-20 | Merrell Dow Pharmaceuticals Inc. | 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors |
CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
EP1603110A3 (fr) | 1995-02-01 | 2006-01-04 | Seiko Epson Corporation | Substrat à matrice active et dispositf d'affichage à cristaux liquide avec le même |
KR20040012751A (ko) * | 2001-04-17 | 2004-02-11 | 아레스 트레이딩 에스.에이. | 보조 생식을 고양하기 위한 아로마타제 저해 |
DE10141937A1 (de) * | 2001-08-28 | 2003-03-27 | Alfred Schmidt | Markierung der Aromatase |
EP1854465A1 (fr) * | 2006-05-12 | 2007-11-14 | Alexander Tobias Teichmann | Utilisation du 4,17 béta-dihydroxyandrost-4-ene-3-one pour traiter les cancers |
AU2011237592B2 (en) | 2010-04-08 | 2016-10-27 | Emory University | Substituted androst-4-ene diones |
EP3666276A1 (fr) | 2018-12-14 | 2020-06-17 | dcic Biopharmaceutical Limited | Médicament contre la tumeur positive du récepteur d'oestrogene beta (erbeta) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3102127A (en) * | 1962-06-12 | 1963-08-27 | Syntex Corp | 19-methylene-androstane derivatives |
FR1519387A (fr) * | 1966-04-20 | 1968-03-29 | Hoffmann La Roche | Procédé pour la préparation de 19-alcényl-stéroïdes |
DE2310963A1 (de) * | 1972-04-14 | 1974-09-05 | Schering Ag | Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten |
CH606101A5 (fr) * | 1975-01-30 | 1978-10-13 | Ciba Geigy Ag |
-
1980
- 1980-06-27 US US06/163,453 patent/US4289762A/en not_active Expired - Lifetime
-
1981
- 1981-06-22 CA CA000380342A patent/CA1173432A/fr not_active Expired
- 1981-06-22 IL IL63142A patent/IL63142A0/xx not_active IP Right Cessation
- 1981-06-22 ZA ZA814219A patent/ZA814219B/xx unknown
- 1981-06-22 NZ NZ197495A patent/NZ197495A/en unknown
- 1981-06-22 PH PH25799A patent/PH16690A/en unknown
- 1981-06-24 DE DE3124719A patent/DE3124719C2/de not_active Expired - Fee Related
- 1981-06-25 SE SE8103988A patent/SE448878B/sv not_active IP Right Cessation
- 1981-06-25 CH CH4213/81A patent/CH647532A5/de not_active IP Right Cessation
- 1981-06-26 GB GB8119814A patent/GB2078750B/en not_active Expired
- 1981-06-26 IE IE1435/81A patent/IE51352B1/en not_active IP Right Cessation
- 1981-06-26 IT IT8148781A patent/IT1171340B/it active
- 1981-06-26 FR FR8112643A patent/FR2485544A1/fr active Granted
- 1981-06-26 ES ES503451A patent/ES503451A0/es active Granted
- 1981-06-26 NL NL8103098A patent/NL8103098A/nl not_active Application Discontinuation
- 1981-06-26 BE BE0/205232A patent/BE889404A/fr not_active IP Right Cessation
- 1981-06-26 AT AT0285881A patent/AT377989B/de not_active IP Right Cessation
- 1981-06-26 DK DK284481A patent/DK163129C/da not_active IP Right Cessation
- 1981-06-27 JP JP9909781A patent/JPS5738798A/ja active Granted
- 1981-06-30 AU AU72369/81A patent/AU539215B2/en not_active Ceased
- 1981-07-22 NO NO81812509A patent/NO156694C/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU539215B2 (en) | 1984-09-13 |
IE51352B1 (en) | 1986-12-10 |
SE448878B (sv) | 1987-03-23 |
AT377989B (de) | 1985-05-28 |
JPH0121158B2 (fr) | 1989-04-19 |
GB2078750B (en) | 1984-08-22 |
US4289762A (en) | 1981-09-15 |
NL8103098A (nl) | 1982-01-18 |
DK284481A (da) | 1981-12-28 |
FR2485544A1 (fr) | 1981-12-31 |
IT8148781A0 (it) | 1981-06-26 |
FR2485544B1 (fr) | 1983-12-16 |
DE3124719C2 (de) | 1994-03-03 |
NO156694B (no) | 1987-07-27 |
CA1173432A (fr) | 1984-08-28 |
SE8103988L (sv) | 1981-12-28 |
IT1171340B (it) | 1987-06-10 |
AU7236981A (en) | 1982-01-07 |
ZA814219B (en) | 1982-07-28 |
CH647532A5 (de) | 1985-01-31 |
ATA285881A (de) | 1984-10-15 |
NO156694C (no) | 1987-11-04 |
PH16690A (en) | 1984-01-06 |
IL63142A0 (en) | 1981-09-13 |
DK163129C (da) | 1992-06-09 |
NZ197495A (en) | 1985-01-31 |
NO812509L (no) | 1983-01-24 |
IE811435L (en) | 1981-12-27 |
ES8400449A1 (es) | 1983-11-01 |
DK163129B (da) | 1992-01-20 |
GB2078750A (en) | 1982-01-13 |
ES503451A0 (es) | 1983-11-01 |
DE3124719A1 (de) | 1982-03-18 |
JPS5738798A (en) | 1982-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: MERRELL DOW PHARMACEUTICALS INC. Effective date: 19940630 |