DE3050895C2 - - Google Patents
Info
- Publication number
- DE3050895C2 DE3050895C2 DE3050895A DE3050895A DE3050895C2 DE 3050895 C2 DE3050895 C2 DE 3050895C2 DE 3050895 A DE3050895 A DE 3050895A DE 3050895 A DE3050895 A DE 3050895A DE 3050895 C2 DE3050895 C2 DE 3050895C2
- Authority
- DE
- Germany
- Prior art keywords
- compound
- dioxide
- compounds
- mmol
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7905020 | 1979-02-13 | ||
GB7921341 | 1979-06-19 | ||
GB7927761 | 1979-08-09 | ||
GB7939473 | 1979-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3050895C2 true DE3050895C2 (US06174465-20010116-C00003.png) | 1989-05-03 |
Family
ID=27449109
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3005164A Expired DE3005164C2 (de) | 1979-02-13 | 1980-02-12 | 1,1-Dioxopenicillanoyloxymethyl-6-(D-α-amino-α-phenylacetamido)-penicillanat, Verfahren zu seiner Herstellung und es enthaltendes Arzneimittel |
DE3050895A Expired DE3050895C2 (US06174465-20010116-C00003.png) | 1979-02-13 | 1980-02-12 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3005164A Expired DE3005164C2 (de) | 1979-02-13 | 1980-02-12 | 1,1-Dioxopenicillanoyloxymethyl-6-(D-α-amino-α-phenylacetamido)-penicillanat, Verfahren zu seiner Herstellung und es enthaltendes Arzneimittel |
Country Status (33)
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4420426A (en) | 1979-03-05 | 1983-12-13 | Pfizer Inc. | 6-Alpha-halopenicillanic acid 1,1-dioxides |
US4714761A (en) * | 1979-03-05 | 1987-12-22 | Pfizer Inc. | 6,6-dihalopenicillanic acid 1,1-dioxides and process |
SE449103B (sv) * | 1979-03-05 | 1987-04-06 | Pfizer | Sett att framstella penicillansyra-1,1-dioxid samt estrar derav |
US4244951A (en) * | 1979-05-16 | 1981-01-13 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
US4309347A (en) * | 1979-05-16 | 1982-01-05 | Pfizer Inc. | Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide |
US4364957A (en) * | 1979-09-26 | 1982-12-21 | Pfizer Inc. | Bis-esters of alkanediols as antibacterial agents |
US4342768A (en) * | 1979-10-22 | 1982-08-03 | Pfizer Inc. | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics |
US4432970A (en) * | 1979-11-23 | 1984-02-21 | Pfizer Inc. | 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
IL61880A (en) * | 1980-01-21 | 1984-11-30 | Bristol Myers Co | 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them |
ZA81306B (en) * | 1980-01-21 | 1982-02-24 | Bristol Myers Co | Chemical compounds |
US4340539A (en) | 1980-01-21 | 1982-07-20 | Bristol-Myers Company | Derivatives of 6-bromo penicillanic acid |
US4488994A (en) * | 1980-09-08 | 1984-12-18 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
IE51516B1 (en) * | 1980-10-06 | 1987-01-07 | Leo Pharm Prod Ltd | 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate |
IL64009A (en) * | 1980-10-31 | 1984-09-30 | Rech Applications Therap | Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them |
US4380512A (en) * | 1980-12-11 | 1983-04-19 | Bristol-Myers Company | 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof |
US4474698A (en) * | 1980-12-11 | 1984-10-02 | Pfizer Inc. | Process for preparing esters of penicillanic acid sulfone |
IN159362B (US06174465-20010116-C00003.png) * | 1981-03-23 | 1987-05-09 | Pfizer | |
IN157669B (US06174465-20010116-C00003.png) * | 1981-03-23 | 1986-05-17 | Pfizer | |
US4376076A (en) | 1981-03-23 | 1983-03-08 | Pfizer Inc. | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide |
US4321196A (en) | 1981-03-23 | 1982-03-23 | Pfizer Inc. | Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide |
US4419284A (en) | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
US4393001A (en) | 1981-03-23 | 1983-07-12 | Pfizer Inc. | Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates |
US4381263A (en) * | 1981-03-23 | 1983-04-26 | Pfizer Inc. | Process for the preparation of penicillanic acid esters |
US4444687A (en) * | 1981-06-08 | 1984-04-24 | Bristol-Myers Company | 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters |
US4582829A (en) * | 1981-09-09 | 1986-04-15 | Pfizer Inc. | Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds |
US4540687A (en) * | 1981-09-09 | 1985-09-10 | Pfizer Inc. | Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds |
PL136237B1 (en) * | 1981-09-09 | 1986-02-28 | Pfizer Inc | Process for preparing novel derivatives of 6'-/2-amino-/4-acyloxyphenyl/acetamido/-penicillanoyloxymethyl penicillanate 1,1-dioxide |
US4351840A (en) * | 1981-09-18 | 1982-09-28 | Pfizer Inc. | Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives |
US4457924A (en) * | 1981-12-22 | 1984-07-03 | Pfizer, Inc. | 1,1-Alkanediol dicarboxylate linked antibacterial agents |
US4359472A (en) | 1981-12-22 | 1982-11-16 | Pfizer Inc. | Bis-hydroxymethyl carbonate bridged antibacterial agents |
US4452796A (en) * | 1982-06-14 | 1984-06-05 | Pfizer Inc. | 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
EP0084730A1 (en) * | 1982-01-22 | 1983-08-03 | Beecham Group Plc | Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use |
US4444686A (en) * | 1982-01-25 | 1984-04-24 | Pfizer Inc. | Crystalline penicillin ester intermediate |
US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
IT1190897B (it) * | 1982-06-29 | 1988-02-24 | Opos Biochimica Srl | Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico |
EP0126090A1 (en) * | 1982-10-26 | 1984-11-28 | Beecham Group Plc | Beta-lactam compounds, preparation and use |
US4530792A (en) * | 1982-11-01 | 1985-07-23 | Pfizer Inc. | Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate |
IL67637A0 (en) * | 1983-01-07 | 1983-05-15 | Orvet Bv | Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates |
US4868297A (en) * | 1982-12-06 | 1989-09-19 | Pfizer Inc. | Process for preparing sultamicillin and analogs |
US4462934A (en) | 1983-03-31 | 1984-07-31 | Pfizer Inc. | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
US4536393A (en) * | 1983-06-06 | 1985-08-20 | Pfizer Inc. | 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor |
JPH01139584A (ja) * | 1987-11-25 | 1989-06-01 | Yoshitomi Pharmaceut Ind Ltd | ペニシラン酸化合物の製造法 |
KR910009271B1 (ko) * | 1989-06-20 | 1991-11-08 | 김영설 | 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 |
WO1991016326A1 (en) * | 1990-04-13 | 1991-10-31 | Pfizer Inc. | Process for sultamicillin intermediate |
ES2161602B1 (es) * | 1999-04-08 | 2003-02-16 | Asturpharma S A | Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina. |
WO2007004239A1 (en) * | 2005-07-06 | 2007-01-11 | Morepen Laboratories Limited | New polymorphic form of sultamicillin tosylate and a process therefor |
TR201922977A2 (tr) * | 2019-12-31 | 2021-07-26 | T C Erciyes Ueniversitesi | Penisilin türevleri ve bunların sentezlenmesi için yöntem |
CN115385934A (zh) * | 2022-10-26 | 2022-11-25 | 北京纳百生物科技有限公司 | 一种舒巴坦半抗原及其合成方法和应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2114330A1 (de) * | 1970-03-24 | 1971-10-14 | Leo Pharm Prod Ltd | Penicillinester |
DE2221912A1 (de) * | 1971-05-05 | 1972-11-16 | Leo Pharm Prod Ltd | Penicillinester,deren Salze und Verfahren zu ihrer Herstellung |
DE2707577A1 (de) * | 1976-02-25 | 1977-09-01 | Leo Pharm Prod Ltd | Amidinopenicillanoyloxyalkyl- cephalosporanate |
DE2716172A1 (de) * | 1976-04-15 | 1977-10-27 | Leo Pharm Prod Ltd | Bis-penicillanoyloxy-alkane |
DE2824535A1 (de) * | 1977-06-07 | 1978-12-14 | Pfizer | Penicillansaeure-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
DE3018590A1 (de) * | 1979-05-16 | 1980-11-20 | Pfizer | Bisester von methandiol mit penicillinen und penicillansaeure-1,1-dioxid |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3838152A (en) * | 1971-10-07 | 1974-09-24 | American Home Prod | Poly alpha-amino penicillins |
GB1467604A (en) * | 1974-06-27 | 1977-03-16 | Toyama Chemical Co Ltd | Bis-type penicillins and process for producing the same |
GB1578128A (en) * | 1976-03-30 | 1980-11-05 | Leo Pharm Prod Ltd | Amidinopenicillanoyloxyalkyl amoxycillinates |
US4197240A (en) * | 1977-12-23 | 1980-04-08 | Yeda Research And Development Co. Ltd. | Penicillin derivatives |
-
1980
- 1980-01-21 IE IE111/80A patent/IE49880B1/en not_active IP Right Cessation
- 1980-01-21 IE IE2654/83A patent/IE49881B1/en unknown
- 1980-01-23 IL IL59203A patent/IL59203A/xx unknown
- 1980-01-24 US US06/118,063 patent/US4840944A/en not_active Expired - Lifetime
- 1980-01-25 PH PH23555A patent/PH16326A/en unknown
- 1980-01-25 CY CY1205A patent/CY1205A/xx unknown
- 1980-01-25 GB GB8002682A patent/GB2044255B/en not_active Expired
- 1980-01-25 GB GB08221654A patent/GB2108107B/en not_active Expired
- 1980-01-30 NZ NZ192762A patent/NZ192762A/en unknown
- 1980-01-31 YU YU244/80A patent/YU42659B/xx unknown
- 1980-01-31 AR AR279816A patent/AR230286A1/es active
- 1980-02-05 AT AT0061580A patent/AT368507B/de not_active IP Right Cessation
- 1980-02-07 CA CA000345227A patent/CA1230113A/en not_active Expired
- 1980-02-07 NL NL8000775A patent/NL8000775A/nl not_active Application Discontinuation
- 1980-02-08 PT PT70805A patent/PT70805A/pt active IP Right Revival
- 1980-02-08 MA MA18928A patent/MA18731A1/fr unknown
- 1980-02-11 FI FI800411A patent/FI73220C/fi not_active IP Right Cessation
- 1980-02-11 DD DD80218994A patent/DD149529A5/de unknown
- 1980-02-11 CH CH110080A patent/CH646436A5/de not_active IP Right Cessation
- 1980-02-12 DE DE3005164A patent/DE3005164C2/de not_active Expired
- 1980-02-12 DE DE3050895A patent/DE3050895C2/de not_active Expired
- 1980-02-12 LU LU82164A patent/LU82164A1/fr unknown
- 1980-02-12 FR FR8003061A patent/FR2449089A1/fr active Granted
- 1980-02-12 PL PL1980221964A patent/PL125079B1/pl unknown
- 1980-02-12 GR GR61189A patent/GR74091B/el unknown
- 1980-02-12 ES ES488494A patent/ES488494A0/es active Granted
- 1980-02-12 SE SE8001099A patent/SE446186B/sv not_active IP Right Cessation
- 1980-02-12 CS CS80929A patent/CS234015B2/cs unknown
- 1980-02-12 DK DK059480A patent/DK160943C/da not_active IP Right Cessation
- 1980-02-12 IT IT19865/80A patent/IT1147306B/it active Protection Beyond IP Right Term
- 1980-02-12 AU AU55462/80A patent/AU532531B2/en not_active Ceased
- 1980-02-12 HU HU80310A patent/HU182604B/hu unknown
- 1980-12-04 US US06/213,083 patent/US4342772A/en not_active Expired - Lifetime
-
1983
- 1983-07-21 KE KE3309A patent/KE3309A/xx unknown
- 1983-07-23 SG SG43783A patent/SG43783G/en unknown
- 1983-11-11 CH CH608183A patent/CH645902A5/de not_active IP Right Cessation
-
1984
- 1984-01-12 HK HK56/84A patent/HK5684A/xx not_active IP Right Cessation
- 1984-09-05 SE SE8404462A patent/SE461913B/sv unknown
-
1985
- 1985-12-30 MY MY6/85A patent/MY8500006A/xx unknown
-
1987
- 1987-02-11 FI FI870555A patent/FI76807C/fi not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2114330A1 (de) * | 1970-03-24 | 1971-10-14 | Leo Pharm Prod Ltd | Penicillinester |
DE2221912A1 (de) * | 1971-05-05 | 1972-11-16 | Leo Pharm Prod Ltd | Penicillinester,deren Salze und Verfahren zu ihrer Herstellung |
DE2707577A1 (de) * | 1976-02-25 | 1977-09-01 | Leo Pharm Prod Ltd | Amidinopenicillanoyloxyalkyl- cephalosporanate |
DE2716172A1 (de) * | 1976-04-15 | 1977-10-27 | Leo Pharm Prod Ltd | Bis-penicillanoyloxy-alkane |
DE2824535A1 (de) * | 1977-06-07 | 1978-12-14 | Pfizer | Penicillansaeure-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
DE3018590A1 (de) * | 1979-05-16 | 1980-11-20 | Pfizer | Bisester von methandiol mit penicillinen und penicillansaeure-1,1-dioxid |
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Legal Events
Date | Code | Title | Description |
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Free format text: GODTFREDSEN, WAGN OLE, DR.PHIL., VAERLOESE, DK DAEHNE, WELF VON, DR.RER.NAT., RUNGSTED KYST, DK |
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D2 | Grant after examination | ||
8364 | No opposition during term of opposition |