DE3048264A1 - 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3048264A1
DE3048264A1 DE19803048264 DE3048264A DE3048264A1 DE 3048264 A1 DE3048264 A1 DE 3048264A1 DE 19803048264 DE19803048264 DE 19803048264 DE 3048264 A DE3048264 A DE 3048264A DE 3048264 A1 DE3048264 A1 DE 3048264A1
Authority
DE
Germany
Prior art keywords
group
dihydro
molecular weight
low molecular
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803048264
Other languages
German (de)
English (en)
Inventor
Werner Dipl.-Chem. Dr. Benson
Hans Dipl.-Chem. Dr. 3000 Hannover Liepmann
Wolfgang Dipl.-Chem. Dr. 3167 Burgdorf Milkowski
Dieter Dr.rer.nat. 4123 Allschwil Römer
Horst Dipl.-Chem. Dr.rer.nat. 3000 Hannover Zeugner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to DE19803048264 priority Critical patent/DE3048264A1/de
Priority to DE8181110275T priority patent/DE3171071D1/de
Priority to AT81110275T priority patent/ATE13883T1/de
Priority to EP81110275A priority patent/EP0054839B1/de
Priority to PT74115A priority patent/PT74115B/pt
Priority to US06/330,324 priority patent/US4533662A/en
Priority to PH26630A priority patent/PH21646A/en
Priority to FI814032A priority patent/FI68046C/fi
Priority to JP56202628A priority patent/JPS57123171A/ja
Priority to ES508113A priority patent/ES8300721A1/es
Priority to IE2989/81A priority patent/IE51799B1/en
Priority to HU813849A priority patent/HU187397B/hu
Priority to CA000392654A priority patent/CA1173440A/en
Priority to GR66843A priority patent/GR82268B/el
Priority to IL64584A priority patent/IL64584A/xx
Priority to NZ199318A priority patent/NZ199318A/en
Priority to DK563681A priority patent/DK563681A/da
Priority to AU78654/81A priority patent/AU543172B2/en
Priority to DD81235957A priority patent/DD201789A5/de
Priority to NO814356A priority patent/NO157376C/no
Priority to ZA818775A priority patent/ZA818775B/xx
Publication of DE3048264A1 publication Critical patent/DE3048264A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE19803048264 1980-12-20 1980-12-20 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE3048264A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19803048264 DE3048264A1 (de) 1980-12-20 1980-12-20 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE8181110275T DE3171071D1 (en) 1980-12-20 1981-12-09 2-acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them
AT81110275T ATE13883T1 (de) 1980-12-20 1981-12-09 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
EP81110275A EP0054839B1 (de) 1980-12-20 1981-12-09 2-Acylaminomethyl-1,4-benzodiazepine und deren Salze sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PT74115A PT74115B (en) 1980-12-20 1981-12-11 Process for the preparation of 2-acylaminomethyl-1,4-benzodia- zepines and salts thereof
US06/330,324 US4533662A (en) 1980-12-20 1981-12-14 2-Acylaminomethyl-1,4-benzodiazepine compounds and analgesic use
PH26630A PH21646A (en) 1980-12-20 1981-12-15 2-acylaminomethyl-1,4-benzodiazepine and salts thereof, process for their manufacture and pharmaceutical preparations containing these compounds
FI814032A FI68046C (fi) 1980-12-20 1981-12-16 Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-acylaminometyl-1,4-benzodiazepiner
JP56202628A JPS57123171A (en) 1980-12-20 1981-12-17 2-acylaminomethyl-1,4-benzodiazepine, manufacture and analgesic containing same
ES508113A ES8300721A1 (es) 1980-12-20 1981-12-18 "procedimiento para la preparacion de 2-fenilacilaminometil-1h-2,3-dihidro-1,4-benzodiazepinas".
IE2989/81A IE51799B1 (en) 1980-12-20 1981-12-18 2-acylaminomethyl-1,4-benzodiazepines and salts thereof,a process for their manufacture and pharmaceutical preparations containing these compounds
HU813849A HU187397B (en) 1980-12-20 1981-12-18 Process for producing 2-bracket-acyl-amino-methyl-bracket closed-1,4-benzodiazepine derivatives
CA000392654A CA1173440A (en) 1980-12-20 1981-12-18 2-acyl amino methyl-1,4-benzo diazepine compounds and their acid addition salts, processes for their production, and pharmaceutical compositions containing same
GR66843A GR82268B (enExample) 1980-12-20 1981-12-18
IL64584A IL64584A (en) 1980-12-20 1981-12-18 2-acylaminomethyl-5-phenyl-1,4-benzodiazepines and salts thereof,their manufacture and pharmaceutical compositions containing them
NZ199318A NZ199318A (en) 1980-12-20 1981-12-18 2-phenyl(carbonyl or alkanoyl)aminomethyl-1,2-dihydro-3h-1,4-benzodiazepines
DK563681A DK563681A (da) 1980-12-20 1981-12-18 Fremgangsmaade til fremstilling af 2-phenylacylaminomethyl-1h-2,3-dihydro-1,4-benzodiazepin-forbindelser eller deres optiske isomere eller syreadditionssalte deraf
AU78654/81A AU543172B2 (en) 1980-12-20 1981-12-18 2-acylaminomethyl-1,4-benzodiazepine
DD81235957A DD201789A5 (de) 1980-12-20 1981-12-18 Verfahren zur herstellung von 2-acylaminomethyl-1,4-benzodiazepinen
NO814356A NO157376C (no) 1980-12-20 1981-12-18 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-fenylacylaminomethyl-1,4-benzodiazepiner.
ZA818775A ZA818775B (en) 1980-12-20 1981-12-18 2-acylaminomethyl-1,4-benzodiazepine and salts thereof,a process for their manufacture and pharmaceutical preparations containing these compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803048264 DE3048264A1 (de) 1980-12-20 1980-12-20 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE3048264A1 true DE3048264A1 (de) 1982-09-09

Family

ID=6119800

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19803048264 Withdrawn DE3048264A1 (de) 1980-12-20 1980-12-20 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE8181110275T Expired DE3171071D1 (en) 1980-12-20 1981-12-09 2-acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8181110275T Expired DE3171071D1 (en) 1980-12-20 1981-12-09 2-acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4533662A (enExample)
EP (1) EP0054839B1 (enExample)
JP (1) JPS57123171A (enExample)
AT (1) ATE13883T1 (enExample)
AU (1) AU543172B2 (enExample)
CA (1) CA1173440A (enExample)
DD (1) DD201789A5 (enExample)
DE (2) DE3048264A1 (enExample)
DK (1) DK563681A (enExample)
ES (1) ES8300721A1 (enExample)
FI (1) FI68046C (enExample)
GR (1) GR82268B (enExample)
HU (1) HU187397B (enExample)
IE (1) IE51799B1 (enExample)
IL (1) IL64584A (enExample)
NO (1) NO157376C (enExample)
NZ (1) NZ199318A (enExample)
PH (1) PH21646A (enExample)
PT (1) PT74115B (enExample)
ZA (1) ZA818775B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724237A (en) * 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
US4684646A (en) * 1984-06-26 1987-08-04 Merck & Co., Inc. 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists
EP0170024A3 (en) * 1984-06-26 1990-01-31 Merck & Co. Inc. Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
CA2521907A1 (en) * 2003-04-10 2004-10-21 Pfizer Inc. Bicyclic compounds as nr2b receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2265370C2 (de) * 1972-05-03 1982-12-02 Kali-Chemie Ag, 3000 Hannover 6-Phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocinderivate
DE2353187A1 (de) * 1973-05-02 1974-11-14 Kali Chemie Ag Neue benzodiazepinderivate
US3925358A (en) * 1973-07-27 1975-12-09 Hoffmann La Roche 1-Lower alkyl-2-substituted-1,4-benzodiazepines
BE839365R (fr) * 1976-03-09 1976-09-09 Derives de diazepine
JPS6045875B2 (ja) * 1979-12-07 1985-10-12 エフ・ホフマン・ラ・ロツシユ・ウント・カンパニ−・アクチエンゲゼルシヤフト イミダゾ−ル誘導体
DE2952279A1 (de) * 1979-12-24 1981-06-25 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
US4533662A (en) 1985-08-06
EP0054839A3 (en) 1983-01-05
AU7865481A (en) 1982-07-01
FI68046B (fi) 1985-03-29
ATE13883T1 (de) 1985-07-15
AU543172B2 (en) 1985-04-04
NO157376C (no) 1988-03-09
GR82268B (enExample) 1984-12-13
JPS57123171A (en) 1982-07-31
FI68046C (fi) 1985-07-10
NZ199318A (en) 1983-06-17
HU187397B (en) 1985-12-28
IL64584A0 (en) 1982-03-31
PH21646A (en) 1988-01-13
DE3171071D1 (en) 1985-07-25
NO814356L (no) 1982-06-21
ES508113A0 (es) 1982-11-01
FI814032L (fi) 1982-06-21
PT74115A (en) 1982-01-01
IE812989L (en) 1982-06-20
ES8300721A1 (es) 1982-11-01
PT74115B (en) 1983-05-11
CA1173440A (en) 1984-08-28
DK563681A (da) 1982-06-21
NO157376B (no) 1987-11-30
EP0054839B1 (de) 1985-06-19
JPH0155271B2 (enExample) 1989-11-22
DD201789A5 (de) 1983-08-10
ZA818775B (en) 1982-11-24
IE51799B1 (en) 1987-04-01
EP0054839A2 (de) 1982-06-30
IL64584A (en) 1985-05-31

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Legal Events

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8139 Disposal/non-payment of the annual fee