ES8300721A1 - "procedimiento para la preparacion de 2-fenilacilaminometil-1h-2,3-dihidro-1,4-benzodiazepinas". - Google Patents
"procedimiento para la preparacion de 2-fenilacilaminometil-1h-2,3-dihidro-1,4-benzodiazepinas".Info
- Publication number
- ES8300721A1 ES8300721A1 ES508113A ES508113A ES8300721A1 ES 8300721 A1 ES8300721 A1 ES 8300721A1 ES 508113 A ES508113 A ES 508113A ES 508113 A ES508113 A ES 508113A ES 8300721 A1 ES8300721 A1 ES 8300721A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- substituent
- lower alkyl
- alkyl
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-FENILACILAMINOMETIL-1H-2,3-DIHIDRO-1,4-BENZODIAZEPINAS, ASI COMO DE SUS ISOMEROS OPTICOS Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE R , R , R , R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE ACILACION DE 2-AMINOMETIL-1H-2,3-DIHIDRO-1,4-BENZODIAZEPINAS DE FORMULA (II), O SUS SALES DE ADICION DE ACIDOS, CON UN ACIDO CARBOXILICO O UN DERIVADO REACTIVO DE ACIDO CARBOXILICO DE FORMULA R COY, EN LAS QUE Y ES HIDROXI, HALOGENO O ALCOXI Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A TEMPERATURAS ENTRE -30<025>C Y LA DE EBULLICION DEL DISOLVENTE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANALGESICOS, SEDANTES, DIURETICOS Y ANTIARRITMICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803048264 DE3048264A1 (de) | 1980-12-20 | 1980-12-20 | 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES508113A0 ES508113A0 (es) | 1982-11-01 |
ES8300721A1 true ES8300721A1 (es) | 1982-11-01 |
Family
ID=6119800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508113A Expired ES8300721A1 (es) | 1980-12-20 | 1981-12-18 | "procedimiento para la preparacion de 2-fenilacilaminometil-1h-2,3-dihidro-1,4-benzodiazepinas". |
Country Status (20)
Country | Link |
---|---|
US (1) | US4533662A (es) |
EP (1) | EP0054839B1 (es) |
JP (1) | JPS57123171A (es) |
AT (1) | ATE13883T1 (es) |
AU (1) | AU543172B2 (es) |
CA (1) | CA1173440A (es) |
DD (1) | DD201789A5 (es) |
DE (2) | DE3048264A1 (es) |
DK (1) | DK563681A (es) |
ES (1) | ES8300721A1 (es) |
FI (1) | FI68046C (es) |
GR (1) | GR82268B (es) |
HU (1) | HU187397B (es) |
IE (1) | IE51799B1 (es) |
IL (1) | IL64584A (es) |
NO (1) | NO157376C (es) |
NZ (1) | NZ199318A (es) |
PH (1) | PH21646A (es) |
PT (1) | PT74115B (es) |
ZA (1) | ZA818775B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0170024A3 (en) * | 1984-06-26 | 1990-01-31 | Merck & Co. Inc. | Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions |
US4684646A (en) * | 1984-06-26 | 1987-08-04 | Merck & Co., Inc. | 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists |
US4724237A (en) * | 1984-06-26 | 1988-02-09 | Merck & Co., Inc. | 2-substituted-aminomethyl-1,4-benzodiazepines |
US5439906A (en) * | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
US5426185A (en) * | 1993-11-22 | 1995-06-20 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
JP2006522794A (ja) * | 2003-04-10 | 2006-10-05 | ファイザー株式会社 | Nr2b受容体拮抗物質としての二環系化合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2265370C2 (de) * | 1972-05-03 | 1982-12-02 | Kali-Chemie Ag, 3000 Hannover | 6-Phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocinderivate |
DE2353187A1 (de) * | 1973-05-02 | 1974-11-14 | Kali Chemie Ag | Neue benzodiazepinderivate |
US3925358A (en) * | 1973-07-27 | 1975-12-09 | Hoffmann La Roche | 1-Lower alkyl-2-substituted-1,4-benzodiazepines |
BE839365R (fr) * | 1976-03-09 | 1976-09-09 | Derives de diazepine | |
JPS6045875B2 (ja) * | 1979-12-07 | 1985-10-12 | エフ・ホフマン・ラ・ロツシユ・ウント・カンパニ−・アクチエンゲゼルシヤフト | イミダゾ−ル誘導体 |
DE2952279A1 (de) * | 1979-12-24 | 1981-06-25 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1980
- 1980-12-20 DE DE19803048264 patent/DE3048264A1/de not_active Withdrawn
-
1981
- 1981-12-09 AT AT81110275T patent/ATE13883T1/de active
- 1981-12-09 DE DE8181110275T patent/DE3171071D1/de not_active Expired
- 1981-12-09 EP EP81110275A patent/EP0054839B1/de not_active Expired
- 1981-12-11 PT PT74115A patent/PT74115B/pt unknown
- 1981-12-14 US US06/330,324 patent/US4533662A/en not_active Expired - Fee Related
- 1981-12-15 PH PH26630A patent/PH21646A/en unknown
- 1981-12-16 FI FI814032A patent/FI68046C/fi not_active IP Right Cessation
- 1981-12-17 JP JP56202628A patent/JPS57123171A/ja active Granted
- 1981-12-18 NZ NZ199318A patent/NZ199318A/en unknown
- 1981-12-18 ZA ZA818775A patent/ZA818775B/xx unknown
- 1981-12-18 IL IL64584A patent/IL64584A/xx unknown
- 1981-12-18 DK DK563681A patent/DK563681A/da not_active Application Discontinuation
- 1981-12-18 DD DD81235957A patent/DD201789A5/de unknown
- 1981-12-18 NO NO814356A patent/NO157376C/no unknown
- 1981-12-18 CA CA000392654A patent/CA1173440A/en not_active Expired
- 1981-12-18 IE IE2989/81A patent/IE51799B1/en unknown
- 1981-12-18 GR GR66843A patent/GR82268B/el unknown
- 1981-12-18 HU HU813849A patent/HU187397B/hu unknown
- 1981-12-18 AU AU78654/81A patent/AU543172B2/en not_active Ceased
- 1981-12-18 ES ES508113A patent/ES8300721A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
PH21646A (en) | 1988-01-13 |
FI68046B (fi) | 1985-03-29 |
ES508113A0 (es) | 1982-11-01 |
DD201789A5 (de) | 1983-08-10 |
PT74115A (en) | 1982-01-01 |
DK563681A (da) | 1982-06-21 |
AU7865481A (en) | 1982-07-01 |
EP0054839A2 (de) | 1982-06-30 |
FI68046C (fi) | 1985-07-10 |
US4533662A (en) | 1985-08-06 |
CA1173440A (en) | 1984-08-28 |
JPH0155271B2 (es) | 1989-11-22 |
ATE13883T1 (de) | 1985-07-15 |
AU543172B2 (en) | 1985-04-04 |
HU187397B (en) | 1985-12-28 |
NO814356L (no) | 1982-06-21 |
ZA818775B (en) | 1982-11-24 |
NZ199318A (en) | 1983-06-17 |
GR82268B (es) | 1984-12-13 |
NO157376B (no) | 1987-11-30 |
DE3048264A1 (de) | 1982-09-09 |
FI814032L (fi) | 1982-06-21 |
IE812989L (en) | 1982-06-20 |
DE3171071D1 (en) | 1985-07-25 |
PT74115B (en) | 1983-05-11 |
EP0054839B1 (de) | 1985-06-19 |
EP0054839A3 (en) | 1983-01-05 |
JPS57123171A (en) | 1982-07-31 |
IE51799B1 (en) | 1987-04-01 |
IL64584A (en) | 1985-05-31 |
NO157376C (no) | 1988-03-09 |
IL64584A0 (en) | 1982-03-31 |
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