ES488704A1 - Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro - Google Patents
Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiroInfo
- Publication number
- ES488704A1 ES488704A1 ES488704A ES488704A ES488704A1 ES 488704 A1 ES488704 A1 ES 488704A1 ES 488704 A ES488704 A ES 488704A ES 488704 A ES488704 A ES 488704A ES 488704 A1 ES488704 A1 ES 488704A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- substituted
- nitrogen atom
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- -1 C1-C2-alkoxy Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/05—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Procedimiento para la preparación de amidinas heterocíclicas de condensación espiro, de la fórmula I **(Fórmula)** y de sus sales fisiológicamente compatibles, donde a) n es 1 ó 2; b) R1 y R2 son hidrógeno o radicales alcohilo, que en común con el átomo de nitrógeno pueden formar un anillo de 5, 6 ó 7 miembros, el cual puede estar substituido con grupos alcohilo de 1 a 3 átomos de carbono, alcoxi de 1 a 2 átomos de carbono, hidroxi o alcoxicarbonilo de 1 a 4 átomos de carbono, y donde uno de los átomos de carbono puede estar reemplazado también por un átomo de oxígeno, azufre o nitrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792907070 DE2907070A1 (de) | 1979-02-23 | 1979-02-23 | Heterocyclische spiroverknuepfte amidine und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES488704A1 true ES488704A1 (es) | 1980-09-16 |
Family
ID=6063739
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488706A Expired ES488706A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de isomeros opticos de amidinas heterociclicas de condensacion espiro |
| ES488702A Expired ES488702A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro |
| ES488705A Expired ES488705A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de endo-aril-exo-pirrolin-amidinas |
| ES488704A Expired ES488704A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro |
| ES488703A Expired ES488703A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488706A Expired ES488706A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de isomeros opticos de amidinas heterociclicas de condensacion espiro |
| ES488702A Expired ES488702A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro |
| ES488705A Expired ES488705A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de endo-aril-exo-pirrolin-amidinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488703A Expired ES488703A1 (es) | 1979-02-23 | 1980-02-18 | Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4277470A (es) |
| EP (1) | EP0014996B1 (es) |
| JP (1) | JPS55120563A (es) |
| AT (1) | ATE914T1 (es) |
| AU (1) | AU534240B2 (es) |
| CA (1) | CA1140930A (es) |
| DE (2) | DE2907070A1 (es) |
| DK (1) | DK77280A (es) |
| ES (5) | ES488706A1 (es) |
| IL (1) | IL59441A0 (es) |
| ZA (1) | ZA801041B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507303A (en) * | 1981-12-22 | 1985-03-26 | Sumitomo Chemical Company, Limited | Succinimide derivatives, compositions and method of use |
| SE9904121D0 (sv) | 1999-11-15 | 1999-11-15 | Gustaf Jederstroem | Hydrophobe biomolecular structure |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2911409A (en) * | 1955-07-18 | 1959-11-03 | Upjohn Co | 2-spiro-substituted pyrrolidines |
| US2931805A (en) * | 1958-11-10 | 1960-04-05 | Smith Kline French Lab | Spiro [bicyclo [2. 2. 1] heptane-2, 2'-alkylenimines] |
-
1979
- 1979-02-23 DE DE19792907070 patent/DE2907070A1/de not_active Withdrawn
-
1980
- 1980-02-18 ES ES488706A patent/ES488706A1/es not_active Expired
- 1980-02-18 ES ES488702A patent/ES488702A1/es not_active Expired
- 1980-02-18 ES ES488705A patent/ES488705A1/es not_active Expired
- 1980-02-18 ES ES488704A patent/ES488704A1/es not_active Expired
- 1980-02-18 ES ES488703A patent/ES488703A1/es not_active Expired
- 1980-02-20 EP EP80100835A patent/EP0014996B1/de not_active Expired
- 1980-02-20 DE DE8080100835T patent/DE3060314D1/de not_active Expired
- 1980-02-20 AT AT80100835T patent/ATE914T1/de not_active IP Right Cessation
- 1980-02-21 IL IL59441A patent/IL59441A0/xx unknown
- 1980-02-21 US US06/123,200 patent/US4277470A/en not_active Expired - Lifetime
- 1980-02-22 JP JP2067380A patent/JPS55120563A/ja active Pending
- 1980-02-22 CA CA000346308A patent/CA1140930A/en not_active Expired
- 1980-02-22 ZA ZA00801041A patent/ZA801041B/xx unknown
- 1980-02-22 DK DK77280A patent/DK77280A/da not_active Application Discontinuation
- 1980-02-22 AU AU55806/80A patent/AU534240B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK77280A (da) | 1980-08-24 |
| IL59441A0 (en) | 1980-05-30 |
| JPS55120563A (en) | 1980-09-17 |
| ZA801041B (en) | 1981-03-25 |
| US4277470A (en) | 1981-07-07 |
| EP0014996B1 (de) | 1982-04-28 |
| ES488702A1 (es) | 1980-09-16 |
| DE2907070A1 (de) | 1980-09-04 |
| ATE914T1 (de) | 1982-05-15 |
| CA1140930A (en) | 1983-02-08 |
| AU5580680A (en) | 1980-08-28 |
| ES488703A1 (es) | 1980-09-16 |
| EP0014996A1 (de) | 1980-09-03 |
| DE3060314D1 (en) | 1982-06-09 |
| ES488705A1 (es) | 1980-09-16 |
| AU534240B2 (en) | 1984-01-12 |
| ES488706A1 (es) | 1980-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK420682A (da) | Fremgangsmaade til fremstilling af triazoloquinazoloner eller salte deraf | |
| ES488705A1 (es) | Procedimiento para la preparacion de endo-aril-exo-pirrolin-amidinas | |
| PL245746A1 (en) | Process for preparing 2-hydroxymethyl-6-methyl-4-p-thiolyl-4,5,6,7-tetrahydro-theino/2,3-c/-pyridine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000601 |