DE3029984C2 - 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel - Google Patents

2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel

Info

Publication number
DE3029984C2
DE3029984C2 DE3029984A DE3029984A DE3029984C2 DE 3029984 C2 DE3029984 C2 DE 3029984C2 DE 3029984 A DE3029984 A DE 3029984A DE 3029984 A DE3029984 A DE 3029984A DE 3029984 C2 DE3029984 C2 DE 3029984C2
Authority
DE
Germany
Prior art keywords
general formula
compounds
formula
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3029984A
Other languages
German (de)
English (en)
Other versions
DE3029984A1 (de
Inventor
Geb. Lambert Gudrun Dr. Michel
Bernd Dr. 5100 Aachen Müller
Ulrich Dipl.-Chem. Dr. 5100 Aachen Seipp
Werner Dipl.-Chem. Dr. 5190 Stolberg Vollenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grünenthal GmbH
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Priority to DE3029984A priority Critical patent/DE3029984C2/de
Priority to GR65265A priority patent/GR75238B/el
Priority to IE1357/81A priority patent/IE51308B1/en
Priority to DE8181104982T priority patent/DE3161958D1/de
Priority to AT81104982T priority patent/ATE5884T1/de
Priority to EP81104982A priority patent/EP0045842B1/de
Priority to AU72463/81A priority patent/AU542775B2/en
Priority to NO812338A priority patent/NO154166C/no
Priority to ZA814720A priority patent/ZA814720B/xx
Priority to IL63322A priority patent/IL63322A/xx
Priority to YU1790/81A priority patent/YU42416B/xx
Priority to PT73406A priority patent/PT73406B/pt
Priority to CA000382448A priority patent/CA1169871A/en
Priority to DD81232351A priority patent/DD201590A5/de
Priority to HU812268A priority patent/HU184870B/hu
Priority to US06/290,573 priority patent/US4372971A/en
Priority to JP56122548A priority patent/JPS5754180A/ja
Priority to DK350181A priority patent/DK154214C/da
Priority to ES504618A priority patent/ES8301957A1/es
Priority to SU813314353A priority patent/SU1072801A3/ru
Priority to KR1019810002871A priority patent/KR850000388B1/ko
Priority to FI812452A priority patent/FI72973C/fi
Publication of DE3029984A1 publication Critical patent/DE3029984A1/de
Application granted granted Critical
Publication of DE3029984C2 publication Critical patent/DE3029984C2/de
Priority to MY649/86A priority patent/MY8600649A/xx
Priority to HK261/87A priority patent/HK26187A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Sheet Holders (AREA)
  • Control Of Positive-Displacement Air Blowers (AREA)
DE3029984A 1980-08-08 1980-08-08 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel Expired DE3029984C2 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE3029984A DE3029984C2 (de) 1980-08-08 1980-08-08 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
IE1357/81A IE51308B1 (en) 1980-08-08 1981-06-18 Heterocyclic compounds,medicaments containing them and processes for preparing them
GR65265A GR75238B (enExample) 1980-08-08 1981-06-18
AT81104982T ATE5884T1 (de) 1980-08-08 1981-06-26 Heterocyclische verbindungen, diese enthaltende arzneimittel und verfahren zur herstellung dieser heterocyclischen verbindungen und arzneimittel.
DE8181104982T DE3161958D1 (en) 1980-08-08 1981-06-26 Heterocyclic compounds, medicaments containing them and process for the preparation of these heterocyclic compounds and medicaments
EP81104982A EP0045842B1 (de) 1980-08-08 1981-06-26 Heterocyclische Verbindungen, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser heterocyclischen Verbindungen und Arzneimittel
AU72463/81A AU542775B2 (en) 1980-08-08 1981-07-01 6,9-epoxy prostaglandins
NO812338A NO154166C (no) 1980-08-08 1981-07-09 Fremgangsmaate til fremstilling av terapeutisk aktive 2-oksabicyklo (3.3.0)oktanderivater.
ZA814720A ZA814720B (en) 1980-08-08 1981-07-10 New heterocyclic compounds medicaments containing them and processes for the preparation of these heterocyclic compounds and medicaments
IL63322A IL63322A (en) 1980-08-08 1981-07-15 Prostacyclin analogs,their preparation and pharmaceutical compositions containing them
YU1790/81A YU42416B (en) 1980-08-08 1981-07-20 Process for obtaining new heterocyclic compounds
PT73406A PT73406B (fr) 1980-08-08 1981-07-22 Procede de preparation de composes heterocicliques a structure basique identique a celle de la prostaciclyne naturelle pour la profilaxie et le traitement de maladies de circulation
CA000382448A CA1169871A (en) 1980-08-08 1981-07-24 Process for the preparation of new heterocyclic compounds
DD81232351A DD201590A5 (de) 1980-08-08 1981-08-03 Verfahren zur herstellung von neuen heterocyclischen verbindungen
HU812268A HU184870B (en) 1980-08-08 1981-08-05 Process for producing 1,5-interphenylene-prostacyylin derivatives
JP56122548A JPS5754180A (en) 1980-08-08 1981-08-06 Fukusokankagobutsu fukusokankagobutsuoganjusuruyakuzaioyobifukusokankagobutsunoseiho
DK350181A DK154214C (da) 1980-08-08 1981-08-06 Analogifremgangsmaade til fremstilling af 2-oxabicyclo-(3,3,0)octanderivater
US06/290,573 US4372971A (en) 1980-08-08 1981-08-06 Heterocyclic prostaglandin type compounds, medicaments containing them and processes for the preparation and use of these heterocyclic compounds and medicaments
ES504618A ES8301957A1 (es) 1980-08-08 1981-08-07 Procedimiento para la obtencion de nuevas uniones hterociclicas que presentan analogias con la prostaciclina.
SU813314353A SU1072801A3 (ru) 1980-08-08 1981-08-07 Способ получени производных простациклина или их эпимеров
KR1019810002871A KR850000388B1 (ko) 1980-08-08 1981-08-07 복소환 화합물 및 이의 이성체의 제조방법
FI812452A FI72973C (fi) 1980-08-08 1981-08-07 Foerfarande foer framstaellning av farmakologiskt aktiva 2-oxabicyklo/3.3.0/oktanderivat.
MY649/86A MY8600649A (en) 1980-08-08 1986-12-30 Heterocylic compounds medicaments containing them and processes for preparing these hetecrocyclic compounds and medicaments
HK261/87A HK26187A (en) 1980-08-08 1987-04-02 Heterocyclic compounds, medicaments containing them and process for the preparation of these heterocyclic compounds and medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3029984A DE3029984C2 (de) 1980-08-08 1980-08-08 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
DE3029984A1 DE3029984A1 (de) 1982-02-18
DE3029984C2 true DE3029984C2 (de) 1983-12-15

Family

ID=6109130

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3029984A Expired DE3029984C2 (de) 1980-08-08 1980-08-08 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
DE8181104982T Expired DE3161958D1 (en) 1980-08-08 1981-06-26 Heterocyclic compounds, medicaments containing them and process for the preparation of these heterocyclic compounds and medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8181104982T Expired DE3161958D1 (en) 1980-08-08 1981-06-26 Heterocyclic compounds, medicaments containing them and process for the preparation of these heterocyclic compounds and medicaments

Country Status (23)

Country Link
US (1) US4372971A (enExample)
EP (1) EP0045842B1 (enExample)
JP (1) JPS5754180A (enExample)
KR (1) KR850000388B1 (enExample)
AT (1) ATE5884T1 (enExample)
AU (1) AU542775B2 (enExample)
CA (1) CA1169871A (enExample)
DD (1) DD201590A5 (enExample)
DE (2) DE3029984C2 (enExample)
DK (1) DK154214C (enExample)
ES (1) ES8301957A1 (enExample)
FI (1) FI72973C (enExample)
GR (1) GR75238B (enExample)
HK (1) HK26187A (enExample)
HU (1) HU184870B (enExample)
IE (1) IE51308B1 (enExample)
IL (1) IL63322A (enExample)
MY (1) MY8600649A (enExample)
NO (1) NO154166C (enExample)
PT (1) PT73406B (enExample)
SU (1) SU1072801A3 (enExample)
YU (1) YU42416B (enExample)
ZA (1) ZA814720B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65387A0 (en) * 1981-04-14 1982-05-31 Chinoin Gyogyszer Es Vegyeszet 2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives and a process for the preparation thereof
HU188559B (en) * 1981-12-01 1986-04-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing new inter-m-phenylene-prostacyclin derivatives
IL67332A (en) * 1981-12-01 1985-12-31 Chinoin Gyogyszer Es Vegyeszet Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DE3317159A1 (de) * 1982-05-27 1983-12-01 Grünenthal GmbH, 5190 Stolberg Verfahren zur herstellung von 5z-formen von 2,3,4-trinor-1,5-inter-m-phenylen- prostacyclinderivaten
DE3914735A1 (de) * 1989-05-05 1990-11-08 Gruenenthal Gmbh Pharmakologisch wirksame ester, diese enthaltende arzneimittel und die herstellung dieser ester und arzneimittel

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933895A (en) * 1972-10-30 1976-01-20 The Upjohn Company Oxa-phenylene compounds
US3933898A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE1 -oxa phenylene compounds
US3933899A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE2 -oxa-phenylene compounds
US3933900A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGEo oxa-phenylene compounds
US3933897A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGA1 -oxa-phenylene compounds
US3933896A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGF1.sub.β -oxa phenylene compounds
DE2346706A1 (de) * 1973-09-17 1975-04-03 Hoechst Ag Neue, nicht natuerlich vorkommende analoga von prostansaeuren und verfahren zu ihrer herstellung
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
US4238623A (en) * 1976-03-29 1980-12-09 Miles Laboratories, Inc. 5,6-Benzo analogues of prostaglandin
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
US4207257A (en) * 1977-04-18 1980-06-10 The Upjohn Company Inter-phenylene-13,14-dihydro-PG amides
US4100192A (en) * 1977-04-18 1978-07-11 The Upjohn Company Inter-phenylene-PG amides
IT1088036B (it) 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
IT1099575B (it) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-metil-13,14-deidro-pgi2' suoi sali e suoi 16s- e 16r-metil derivati
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
US4312810A (en) 1978-11-22 1982-01-26 The Upjohn Company 2,5-Inter-o-phenylene-3,4-dinor-5,9α-epoxy-9-deoxy-PGF1 compounds
DE2902809A1 (de) * 1979-01-25 1980-08-07 Hoechst Ag Neue analoga von prostacyclin

Also Published As

Publication number Publication date
CA1169871A (en) 1984-06-26
IL63322A (en) 1985-01-31
JPS6116393B2 (enExample) 1986-04-30
FI72973C (fi) 1987-08-10
DK154214C (da) 1989-03-13
DK154214B (da) 1988-10-24
KR850000388B1 (ko) 1985-03-25
IL63322A0 (en) 1981-10-30
JPS5754180A (en) 1982-03-31
ES504618A0 (es) 1983-01-01
AU7246381A (en) 1982-02-11
ES8301957A1 (es) 1983-01-01
DK350181A (da) 1982-02-09
MY8600649A (en) 1986-12-31
SU1072801A3 (ru) 1984-02-07
US4372971A (en) 1983-02-08
DD201590A5 (de) 1983-07-27
FI812452L (fi) 1982-02-09
EP0045842A1 (de) 1982-02-17
DE3161958D1 (en) 1984-02-23
YU42416B (en) 1988-08-31
ATE5884T1 (de) 1984-02-15
PT73406B (fr) 1982-08-09
YU179081A (en) 1983-06-30
NO812338L (no) 1982-02-09
IE51308B1 (en) 1986-11-26
NO154166B (no) 1986-04-21
KR830006265A (ko) 1983-09-20
NO154166C (no) 1986-07-30
GR75238B (enExample) 1984-07-13
HU184870B (en) 1984-10-29
IE811357L (en) 1982-02-08
AU542775B2 (en) 1985-03-14
EP0045842B1 (de) 1984-01-18
DE3029984A1 (de) 1982-02-18
PT73406A (fr) 1981-08-01
ZA814720B (en) 1982-07-28
FI72973B (fi) 1987-04-30
HK26187A (en) 1987-04-10

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8126 Change of the secondary classification

Ipc: A61K 31/34

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee