DE3026783C2 - Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden - Google Patents

Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden

Info

Publication number
DE3026783C2
DE3026783C2 DE3026783A DE3026783A DE3026783C2 DE 3026783 C2 DE3026783 C2 DE 3026783C2 DE 3026783 A DE3026783 A DE 3026783A DE 3026783 A DE3026783 A DE 3026783A DE 3026783 C2 DE3026783 C2 DE 3026783C2
Authority
DE
Germany
Prior art keywords
methylene
beta
hydroxy
acetoxy
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3026783A
Other languages
German (de)
English (en)
Other versions
DE3026783A1 (de
Inventor
Dieter Bittler
Henry Dr. Laurent
Klaus Dr. Nickisch
Robert Dr. Nickolson
Rudolf Prof. Dr. 1000 Berlin Wiechert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE3026783A priority Critical patent/DE3026783C2/de
Application filed by Schering AG filed Critical Schering AG
Priority to JP56502399A priority patent/JPH0128760B2/ja
Priority to DE8181105132T priority patent/DE3163971D1/de
Priority to US06/359,713 priority patent/US4472310A/en
Priority to EP81105132A priority patent/EP0043994B1/de
Priority to HU813202A priority patent/HU182759B/hu
Priority to AT81105132T priority patent/ATE7791T1/de
Priority to PCT/DE1981/000111 priority patent/WO1982000294A1/de
Priority to CA000384258A priority patent/CA1156646A/en
Publication of DE3026783A1 publication Critical patent/DE3026783A1/de
Priority to DK107382A priority patent/DK107382A/da
Application granted granted Critical
Publication of DE3026783C2 publication Critical patent/DE3026783C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE3026783A 1980-07-11 1980-07-11 Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden Expired DE3026783C2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE3026783A DE3026783C2 (de) 1980-07-11 1980-07-11 Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
DE8181105132T DE3163971D1 (en) 1980-07-11 1981-07-02 5-beta-hydroxy-delta-6-steroids and process for their preparation
US06/359,713 US4472310A (en) 1980-07-11 1981-07-02 5β-Hydroxy-Δ6 -steroids and process for the preparation thereof
EP81105132A EP0043994B1 (de) 1980-07-11 1981-07-02 5Beta-Hydroxy-delta-6-steroide und Verfahren zu ihrer Herstellung
JP56502399A JPH0128760B2 (enExample) 1980-07-11 1981-07-02
HU813202A HU182759B (en) 1980-07-11 1981-07-02 Process for preparing 5beta-hydroxy-delta up 6-steroid derivatives
AT81105132T ATE7791T1 (de) 1980-07-11 1981-07-02 5beta-hydroxy-delta-6-steroide und verfahren zu ihrer herstellung.
PCT/DE1981/000111 WO1982000294A1 (en) 1980-07-11 1981-07-02 5beta-hydroxy-delta 6-steroid derivatives and method for their preparation
CA000384258A CA1156646A (en) 1980-07-11 1981-08-20 5.beta.-HYDROXY-.DELTA..SUP.6-STEROIDS
DK107382A DK107382A (da) 1980-07-11 1982-03-11 5beta-hydroxy-delta6-steroider og fremgangsmaade til fremstilling heraf

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3026783A DE3026783C2 (de) 1980-07-11 1980-07-11 Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden

Publications (2)

Publication Number Publication Date
DE3026783A1 DE3026783A1 (de) 1982-01-28
DE3026783C2 true DE3026783C2 (de) 1982-07-29

Family

ID=6107245

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3026783A Expired DE3026783C2 (de) 1980-07-11 1980-07-11 Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
DE8181105132T Expired DE3163971D1 (en) 1980-07-11 1981-07-02 5-beta-hydroxy-delta-6-steroids and process for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8181105132T Expired DE3163971D1 (en) 1980-07-11 1981-07-02 5-beta-hydroxy-delta-6-steroids and process for their preparation

Country Status (9)

Country Link
US (1) US4472310A (enExample)
EP (1) EP0043994B1 (enExample)
JP (1) JPH0128760B2 (enExample)
AT (1) ATE7791T1 (enExample)
CA (1) CA1156646A (enExample)
DE (2) DE3026783C2 (enExample)
DK (1) DK107382A (enExample)
HU (1) HU182759B (enExample)
WO (1) WO1982000294A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
CN1047598C (zh) * 1993-07-06 1999-12-22 昆明医学院 达玛烷型皂甙人参低元醇衍生物及制备方法
US6233871B1 (en) * 1997-06-11 2001-05-22 I-Chung Ho Design of planter inserts and water reservoirs
DE502005004948D1 (de) 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
DK2527356T3 (en) 2005-07-21 2018-04-09 Bayer Ip Gmbh PROCEDURE FOR PREPARING 3-OXOPREGN-4-EN-21,17-CARBOLACTONES BY METAL-FREE OXIDATION OF 17- (3-HYDROXYPROPYL) -3,17-DIHYDROXYANDROSTANES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798213A (en) * 1971-01-25 1974-03-19 Merck & Co Inc 7 alpha-methyl-20-spiroxane-3-ones and process
DE2251476A1 (de) * 1972-10-20 1974-05-02 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7 alpha-thioacyl-17 beta-hydroxy4-androsten-17 alpha -yl)-propionsaeuregamma -lactonen
CH609357A5 (enExample) * 1973-05-25 1979-02-28 Schering Ag
US3890304A (en) * 1973-11-09 1975-06-17 Searle & Co 7{60 -carbam oyl-17-hydroxy-3-oxo-17{60 -pregn-4-ene-21-carboxylic acid {65 -lactone and related compounds
CH626095A5 (enExample) * 1976-04-06 1981-10-30 Ciba Geigy Ag
DE2716485C2 (de) * 1977-04-14 1985-06-05 Daimler-Benz Ag, 7000 Stuttgart Eine Zusatzmasse zur Beeinflussung von Resonanzschwingungen aufweisender Drehmomentübertragungsstrang

Also Published As

Publication number Publication date
CA1156646A (en) 1983-11-08
DE3026783A1 (de) 1982-01-28
DE3163971D1 (en) 1984-07-12
ATE7791T1 (de) 1984-06-15
JPH0128760B2 (enExample) 1989-06-05
US4472310A (en) 1984-09-18
WO1982000294A1 (en) 1982-02-04
HU182759B (en) 1984-03-28
EP0043994B1 (de) 1984-06-06
JPS57500979A (enExample) 1982-06-03
DK107382A (da) 1982-03-11
EP0043994A1 (de) 1982-01-20

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8339 Ceased/non-payment of the annual fee