DE3012669A1 - Verfahren zur herstellung von derivaten von 7-aminodesacetoxycephalosporansaeure - Google Patents

Verfahren zur herstellung von derivaten von 7-aminodesacetoxycephalosporansaeure

Info

Publication number
DE3012669A1
DE3012669A1 DE19803012669 DE3012669A DE3012669A1 DE 3012669 A1 DE3012669 A1 DE 3012669A1 DE 19803012669 DE19803012669 DE 19803012669 DE 3012669 A DE3012669 A DE 3012669A DE 3012669 A1 DE3012669 A1 DE 3012669A1
Authority
DE
Germany
Prior art keywords
adca
stands
added
mixture
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803012669
Other languages
German (de)
English (en)
Other versions
DE3012669C2 (en, 2012
Inventor
Renato Milano Broggi
Marco Falciani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dobfar SpA
Original Assignee
Dobfar SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dobfar SpA filed Critical Dobfar SpA
Publication of DE3012669A1 publication Critical patent/DE3012669A1/de
Application granted granted Critical
Publication of DE3012669C2 publication Critical patent/DE3012669C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DE19803012669 1979-12-07 1980-04-01 Verfahren zur herstellung von derivaten von 7-aminodesacetoxycephalosporansaeure Granted DE3012669A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT27962/79A IT1126544B (it) 1979-12-07 1979-12-07 Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico

Publications (2)

Publication Number Publication Date
DE3012669A1 true DE3012669A1 (de) 1981-06-11
DE3012669C2 DE3012669C2 (en, 2012) 1991-05-08

Family

ID=11222690

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803012669 Granted DE3012669A1 (de) 1979-12-07 1980-04-01 Verfahren zur herstellung von derivaten von 7-aminodesacetoxycephalosporansaeure

Country Status (10)

Country Link
US (1) US4299955A (en, 2012)
JP (1) JPS5683492A (en, 2012)
KR (1) KR830002454B1 (en, 2012)
CH (1) CH645647A5 (en, 2012)
DE (1) DE3012669A1 (en, 2012)
FR (1) FR2470771A1 (en, 2012)
GB (1) GB2064511B (en, 2012)
IT (1) IT1126544B (en, 2012)
NL (1) NL191239C (en, 2012)
YU (1) YU125780A (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT378370B (de) * 1981-08-03 1985-07-25 Pliva Pharm & Chem Works Verfahren zur herstellung von halbsynthetischen cephalosporinen

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
ES488286A0 (es) * 1980-02-05 1980-12-16 Liofilizaciones Esterilizacion Procedimiento para la obtencion de una sal soluble en agua de cefadroxilo
HU221200B1 (en) * 1990-01-22 2002-08-28 Biochemie Gmbh Process for producing beta-lactames
GB9115203D0 (en) * 1991-07-15 1991-08-28 Biochemie Gmbh Improvements in or relating to beta lactam production
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
US5908929A (en) * 1996-12-05 1999-06-01 Vitara Chemicals Limited Process for the manufacture of the antibiotic 7-(D-α-amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid (cephalexin) and pharmaceutically acceptable salts thereof
US20040077849A1 (en) * 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2263861A1 (de) * 1971-12-28 1973-07-05 Toyama Chemical Co Ltd Verfahren zur herstellung von 7acylamido-3-cephem-4-carbonsaeure
EP0001133A1 (en) * 1977-09-06 1979-03-21 Gist-Brocades N.V. Process for the preparation of 6- D-alpha-amino-(p-hydroxyphenyl)-acetamido penicillanic acid
EP0003329A1 (en) * 1978-02-01 1979-08-08 BIOCHEMIE Gesellschaft m.b.H. Cephalexin-amide complex, process for its production and use in cephalexin-monohydrate production

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
GB1327270A (en) 1970-10-26 1973-08-22 Osaka Univeristy President Of Acylation of 6-aminopenicillanic acid and 7-aminocephalospor anic acids
YU39709B (en) * 1972-09-15 1985-04-30 Bristol Myers Co Process for producing cephalosporin
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
US3965098A (en) 1972-11-29 1976-06-22 American Home Products Corporation Intermediates for preparing cephalosporins and methods of production
GB1472746A (en) * 1973-07-05 1977-05-04 Glaxo Lab Ltd Cephalosporin compounds
GB1473090A (en, 2012) * 1973-07-19 1977-05-11
ES419149A1 (es) * 1973-09-28 1976-07-01 Fener S L Lab Procedimiento para la obtencion de a-amino-penicilinas y cefalosporinas.
NL166831C (nl) * 1974-07-17 1981-09-15 Nederlanden Staat Inrichting voor het bewaken van de kwaliteit van straalverbindingen.
JPS5129489A (en) * 1974-08-30 1976-03-12 Kanebo Ltd Penishirinrui oyobi sefuarosuhorinrui no seizoho
JPS51105091A (en) * 1975-03-12 1976-09-17 Sangyo Kagaku Kenkyu Kyokai Aminoashirukano kairyohoho
JPS5283490A (en) * 1975-12-30 1977-07-12 Tokyo Tanabe Co Process for preparing 77glycylamino cephlospoline derivatives
GB1532682A (en) 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2263861A1 (de) * 1971-12-28 1973-07-05 Toyama Chemical Co Ltd Verfahren zur herstellung von 7acylamido-3-cephem-4-carbonsaeure
EP0001133A1 (en) * 1977-09-06 1979-03-21 Gist-Brocades N.V. Process for the preparation of 6- D-alpha-amino-(p-hydroxyphenyl)-acetamido penicillanic acid
EP0003329A1 (en) * 1978-02-01 1979-08-08 BIOCHEMIE Gesellschaft m.b.H. Cephalexin-amide complex, process for its production and use in cephalexin-monohydrate production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT378370B (de) * 1981-08-03 1985-07-25 Pliva Pharm & Chem Works Verfahren zur herstellung von halbsynthetischen cephalosporinen

Also Published As

Publication number Publication date
CH645647A5 (it) 1984-10-15
IT7927962A0 (it) 1979-12-07
IT1126544B (it) 1986-05-21
KR830002454B1 (ko) 1983-10-26
US4299955A (en) 1981-11-10
FR2470771B1 (en, 2012) 1984-04-27
YU125780A (en) 1983-04-30
DE3012669C2 (en, 2012) 1991-05-08
FR2470771A1 (fr) 1981-06-12
NL191239C (nl) 1995-04-03
GB2064511A (en) 1981-06-17
JPH034555B2 (en, 2012) 1991-01-23
NL8006367A (nl) 1981-07-01
GB2064511B (en) 1983-06-22
NL191239B (nl) 1994-11-01
JPS5683492A (en) 1981-07-08
KR830002774A (ko) 1983-05-30

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee