DE2949491A1 - 1,4-dihydropyridine, ihre herstellung und verwendung - Google Patents
1,4-dihydropyridine, ihre herstellung und verwendungInfo
- Publication number
- DE2949491A1 DE2949491A1 DE19792949491 DE2949491A DE2949491A1 DE 2949491 A1 DE2949491 A1 DE 2949491A1 DE 19792949491 DE19792949491 DE 19792949491 DE 2949491 A DE2949491 A DE 2949491A DE 2949491 A1 DE2949491 A1 DE 2949491A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- group
- compounds
- compound
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH548480A CH654836A5 (en) | 1979-12-08 | 1980-07-17 | Heterocyclic organic compounds and therapeutic agents containing them |
PH24383A PH19536A (en) | 1977-06-20 | 1980-08-01 | Benzoxadiazoles and benzothiadiazoles and pharmaceutical composition containing them |
MX9203580A MX9203580A (es) | 1979-12-08 | 1992-06-26 | 1,4-dihidropiridinas y composiciones farmaceuticas que las contienen. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1283578A CH639659A5 (de) | 1978-12-18 | 1978-12-18 | Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE2949491A1 true DE2949491A1 (de) | 1980-06-26 |
DE2949491C2 DE2949491C2 (xx) | 1988-10-27 |
Family
ID=4386824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19792949491 Granted DE2949491A1 (de) | 1977-06-20 | 1979-12-08 | 1,4-dihydropyridine, ihre herstellung und verwendung |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5583783A (xx) |
AU (1) | AU536055B2 (xx) |
BE (1) | BE880591A (xx) |
CH (1) | CH639659A5 (xx) |
CY (1) | CY1321A (xx) |
DE (1) | DE2949491A1 (xx) |
FR (1) | FR2444681A1 (xx) |
GB (2) | GB2103203B (xx) |
HK (1) | HK16086A (xx) |
IE (1) | IE49496B1 (xx) |
IT (1) | IT1164097B (xx) |
KE (1) | KE3593A (xx) |
MY (1) | MY8500130A (xx) |
NL (2) | NL193066C (xx) |
NZ (1) | NZ192422A (xx) |
SE (1) | SE445219B (xx) |
SG (1) | SG97585G (xx) |
ZA (1) | ZA796842B (xx) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042089A2 (de) * | 1980-06-12 | 1981-12-23 | Bayer Ag | 4-Heteroring-substituierte Dihydropyridine, Verfahren zu ihrer Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung |
DE3136031A1 (de) * | 1980-09-18 | 1982-04-08 | Sandoz-Patent-GmbH, 7850 Lörrach | Pharmazeutische zusammensetzungen, wirksam gegen koronare herzkrankheiten und hohen blutdruck |
FR2528431A1 (fr) * | 1982-06-15 | 1983-12-16 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments |
AT384219B (de) * | 1982-06-15 | 1987-10-12 | Sandoz Ag | Herstellung von neuen 1,4-dihydropyridinderivaten in optisch aktiver oder racematform |
WO1994001405A1 (de) * | 1992-07-10 | 1994-01-20 | Siegfried Goldmann | Lichtaktivierbare 1-(2-nitrobenzyl)-substituierte 1,4-dihydropyridine |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3269219D1 (en) * | 1981-11-17 | 1986-03-27 | Fisons Plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
JPS5978186A (ja) * | 1982-10-27 | 1984-05-04 | Yoshitomi Pharmaceut Ind Ltd | 1,4−ジヒドロピリジン−3,5−ジカルボン酸エステル誘導体 |
US4794111A (en) * | 1984-05-23 | 1988-12-27 | Bayer Aktiengesellschaft | Dihydropyridine preparations containing β-blockers |
NL194389C (nl) * | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
US5260321A (en) * | 1984-11-12 | 1993-11-09 | Sandoz Ltd. | Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
NL194822C (nl) * | 1985-10-01 | 2003-04-03 | Novartis Ag | Preparaat voor orale toediening met geregelde afgifte en werkwijze voor de bereiding ervan. |
DE3542794A1 (de) * | 1985-12-04 | 1987-06-11 | Bayer Ag | Antihypertensives kombinationspraeparat |
GB8626217D0 (en) * | 1986-11-03 | 1986-12-03 | Sandoz Ltd | Pharmaceutical compositions |
US4816263A (en) * | 1987-10-02 | 1989-03-28 | Alza Corporation | Dosage form for treating cardiovascular diseases comprising isradipine |
KR940003492B1 (ko) * | 1988-10-27 | 1994-04-23 | 주식회사 유한양행 | 1,4-디하이드로피리딘유도체 및 그의 제조방법 |
JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
WO2005023787A1 (en) * | 2003-09-10 | 2005-03-17 | Shasun Chemicals And Drugs Limited | Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde |
CN103613584B (zh) * | 2013-11-27 | 2016-04-27 | 沈阳药科大学 | 一种伊拉地平合成产物后处理的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670824A1 (de) * | 1967-03-20 | 1971-04-01 | Bayer Ag | Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten |
DE2635916A1 (de) * | 1975-08-12 | 1977-02-24 | Hexachimie | Dihydro-1,4-pyridine und diese enthaltende heilmittel |
DE2616991A1 (de) * | 1976-04-17 | 1977-10-27 | Bayer Ag | Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5373327A (en) * | 1976-12-13 | 1978-06-29 | Matsushita Electric Ind Co Ltd | Power source system |
DK149855C (da) * | 1977-06-20 | 1987-04-21 | Sandoz Ag | Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater |
-
1978
- 1978-12-18 CH CH1283578A patent/CH639659A5/de not_active IP Right Cessation
-
1979
- 1979-12-08 DE DE19792949491 patent/DE2949491A1/de active Granted
- 1979-12-11 SE SE7910188A patent/SE445219B/sv not_active IP Right Cessation
- 1979-12-13 BE BE1/9643A patent/BE880591A/fr not_active IP Right Cessation
- 1979-12-14 CY CY1321A patent/CY1321A/xx unknown
- 1979-12-14 GB GB08215988A patent/GB2103203B/en not_active Expired
- 1979-12-14 GB GB7943113A patent/GB2037766B/en not_active Expired
- 1979-12-14 IT IT51095/79A patent/IT1164097B/it active Protection Beyond IP Right Term
- 1979-12-14 NL NL7909024A patent/NL193066C/nl not_active IP Right Cessation
- 1979-12-17 AU AU53896/79A patent/AU536055B2/en not_active Expired
- 1979-12-17 FR FR7930829A patent/FR2444681A1/fr active Granted
- 1979-12-17 IE IE2445/79A patent/IE49496B1/en not_active IP Right Cessation
- 1979-12-17 JP JP16396579A patent/JPS5583783A/ja active Granted
- 1979-12-17 NZ NZ192422A patent/NZ192422A/xx unknown
- 1979-12-18 ZA ZA00796842A patent/ZA796842B/xx unknown
-
1985
- 1985-12-20 SG SG975/85A patent/SG97585G/en unknown
- 1985-12-30 MY MY130/85A patent/MY8500130A/xx unknown
-
1986
- 1986-01-08 KE KE3593A patent/KE3593A/xx unknown
- 1986-03-06 HK HK160/86A patent/HK16086A/xx not_active IP Right Cessation
-
1999
- 1999-05-11 NL NL990014C patent/NL990014I1/nl unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670824A1 (de) * | 1967-03-20 | 1971-04-01 | Bayer Ag | Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten |
DE2635916A1 (de) * | 1975-08-12 | 1977-02-24 | Hexachimie | Dihydro-1,4-pyridine und diese enthaltende heilmittel |
DE2616991A1 (de) * | 1976-04-17 | 1977-10-27 | Bayer Ag | Heterocyclisch-substituierte schwefelhaltige dihydropyridine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Non-Patent Citations (3)
Title |
---|
BURGER: Medicinal Chemistry, 4. Aufl., Bd. 3, S.319, (gutachtlich genannt) * |
EP-PS 150 (gutachtlich genannt) * |
J. of Cardiovescular Pharmacology, 6, 407, 1984 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0042089A2 (de) * | 1980-06-12 | 1981-12-23 | Bayer Ag | 4-Heteroring-substituierte Dihydropyridine, Verfahren zu ihrer Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung |
EP0042089A3 (en) * | 1980-06-12 | 1982-09-22 | Bayer Ag | 4-heterocylic substituted dihydropyridines, processes for preparing them, their therapeutical use and their preparation |
DE3136031A1 (de) * | 1980-09-18 | 1982-04-08 | Sandoz-Patent-GmbH, 7850 Lörrach | Pharmazeutische zusammensetzungen, wirksam gegen koronare herzkrankheiten und hohen blutdruck |
FR2528431A1 (fr) * | 1982-06-15 | 1983-12-16 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments |
WO1984000033A1 (en) * | 1982-06-15 | 1984-01-05 | Sandoz Ag | 1,4-dihydro-pyridine derivatives, preparation thereof and pharmaceutical compositions containing them |
AT384219B (de) * | 1982-06-15 | 1987-10-12 | Sandoz Ag | Herstellung von neuen 1,4-dihydropyridinderivaten in optisch aktiver oder racematform |
WO1994001405A1 (de) * | 1992-07-10 | 1994-01-20 | Siegfried Goldmann | Lichtaktivierbare 1-(2-nitrobenzyl)-substituierte 1,4-dihydropyridine |
US5606066A (en) * | 1992-07-10 | 1997-02-25 | Goldmann; Siegfried | Light activable "caged" 1-(2-nitrobenzyl)-substituted 1,4-dihydropyridines |
Also Published As
Publication number | Publication date |
---|---|
AU5389679A (en) | 1980-06-26 |
SE445219B (sv) | 1986-06-09 |
BE880591A (fr) | 1980-06-13 |
HK16086A (en) | 1986-03-14 |
SG97585G (en) | 1986-07-18 |
GB2103203A (en) | 1983-02-16 |
IT7951095A0 (it) | 1979-12-14 |
NL193066B (nl) | 1998-05-06 |
AU536055B2 (en) | 1984-04-19 |
GB2037766A (en) | 1980-07-16 |
NZ192422A (en) | 1982-09-14 |
GB2037766B (en) | 1983-02-16 |
FR2444681B1 (xx) | 1982-10-29 |
SE7910188L (sv) | 1980-06-19 |
NL7909024A (nl) | 1980-06-20 |
FR2444681A1 (fr) | 1980-07-18 |
MY8500130A (en) | 1985-12-31 |
KE3593A (en) | 1986-02-07 |
NL990014I1 (nl) | 1999-07-01 |
IT1164097B (it) | 1987-04-08 |
JPH0369910B2 (xx) | 1991-11-05 |
CH639659A5 (de) | 1983-11-30 |
DE2949491C2 (xx) | 1988-10-27 |
ZA796842B (en) | 1981-07-29 |
JPS5583783A (en) | 1980-06-24 |
NL193066C (nl) | 1998-09-08 |
CY1321A (en) | 1986-06-27 |
GB2103203B (en) | 1983-06-08 |
IE49496B1 (en) | 1985-10-16 |
IE792445L (en) | 1980-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029 Spc suppl protection certif: 193 75 087 Filing date: 19930630 |
|
V457 | Spc granted |
Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029 Spc suppl protection certif: 193 75 087 Filing date: 19930630 |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
8328 | Change in the person/name/address of the agent |
Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN |
|
V464 | Spc expired |
Free format text: PRODUCT NAME: ISRADIPIN; REGISTRATION NO/DATE: 17474.00.00, 17475.00.00, 22629.00.00; 19901029 Spc suppl protection certif: 193 75 087 Filing date: 19930630 |