DE2845745C2 - - Google Patents

Info

Publication number
DE2845745C2
DE2845745C2 DE2845745A DE2845745A DE2845745C2 DE 2845745 C2 DE2845745 C2 DE 2845745C2 DE 2845745 A DE2845745 A DE 2845745A DE 2845745 A DE2845745 A DE 2845745A DE 2845745 C2 DE2845745 C2 DE 2845745C2
Authority
DE
Germany
Prior art keywords
prp
pertussis
phosphate buffer
isolation
sodium phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2845745A
Other languages
German (de)
English (en)
Other versions
DE2845745A1 (de
Inventor
Joseph S.-C. Orangeburg N.Y. Us Kuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/846,466 external-priority patent/US4196192A/en
Priority claimed from US05/846,488 external-priority patent/US4220717A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE2845745A1 publication Critical patent/DE2845745A1/de
Application granted granted Critical
Publication of DE2845745C2 publication Critical patent/DE2845745C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19782845745 1977-10-28 1978-10-20 Kombinationsvaccine Granted DE2845745A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/846,466 US4196192A (en) 1977-10-28 1977-10-28 Combined Haemophilus influenzae type b and pertussis vaccine
US05/846,488 US4220717A (en) 1977-12-22 1977-12-22 Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.

Publications (2)

Publication Number Publication Date
DE2845745A1 DE2845745A1 (de) 1979-05-10
DE2845745C2 true DE2845745C2 (fr) 1987-10-01

Family

ID=27126641

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782845745 Granted DE2845745A1 (de) 1977-10-28 1978-10-20 Kombinationsvaccine

Country Status (25)

Country Link
JP (1) JPS5480408A (fr)
AR (1) AR218932A1 (fr)
AU (1) AU520902B2 (fr)
BE (1) BE871586A (fr)
CA (1) CA1117866A (fr)
CH (1) CH649781A5 (fr)
DD (1) DD140701A5 (fr)
DE (1) DE2845745A1 (fr)
DK (1) DK154327C (fr)
ES (1) ES474611A1 (fr)
FI (1) FI63674C (fr)
FR (1) FR2407000B1 (fr)
GB (1) GB2007244B (fr)
GR (1) GR73991B (fr)
HU (1) HU178166B (fr)
IE (1) IE47474B1 (fr)
IL (1) IL55433A (fr)
IT (1) IT1107570B (fr)
NL (1) NL7810753A (fr)
NO (1) NO149611C (fr)
NZ (1) NZ188211A (fr)
PH (1) PH15882A (fr)
PL (1) PL210545A1 (fr)
SE (1) SE430753B (fr)
YU (1) YU250878A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
CA1209036A (fr) * 1982-08-20 1986-08-05 Joseph S.C. Kuo Vaccin combine contre haemophilus influenzae, la diphterie, la coqueluche et le tetanos
US4744982A (en) * 1982-08-24 1988-05-17 Hunter Kenneth W Human monoclonal antibody reactive with polyribosylribitol phosphate
DE69113564T2 (de) * 1990-08-13 1996-05-30 American Cyanamid Co Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
WO1993004183A1 (fr) * 1991-08-16 1993-03-04 Merck & Co., Inc. Procede de conversion d'un polysaccharide capsulaire bacterien contenant des lipides en polysaccharide sans lipide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395219A (en) * 1964-12-11 1968-07-30 Merck & Co Inc Process for production of pertussis antigen
NO116869B (fr) * 1965-01-19 1969-06-02 Merck & Co Inc
US3465078A (en) * 1965-10-21 1969-09-02 Sydney Z Spiesel Method of recovering antigens from bordetella pertussis cells
NL174267B (nl) * 1969-05-20 Roussel Uclaf Verbetering van de werkwijze voor de bereiding van een somatisch antigeen volgens het nederlandse octrooischrift 169754 en werkwijze ter bereiding van een farmaceutisch preparaat.
US3636192A (en) * 1970-01-13 1972-01-18 Us Army Meningococcal polysaccharide vaccines
FR2253499B1 (fr) * 1973-12-10 1977-11-04 Fabre Sa Pierre
DE2461439C3 (de) * 1974-12-24 1980-03-20 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines schützenden Antigens von Bordetella Pertussis sowie jenes enthaltendes Mittel
US3978209A (en) * 1975-03-24 1976-08-31 Merck & Co., Inc. Endotoxin free meningococcus polysaccharides

Also Published As

Publication number Publication date
SE430753B (sv) 1983-12-12
NO149611B (no) 1984-02-13
DD140701A5 (de) 1980-03-26
IE47474B1 (en) 1984-03-21
NZ188211A (en) 1984-09-28
IL55433A0 (en) 1978-10-31
AU4108178A (en) 1980-05-01
CH649781A5 (de) 1985-06-14
PL210545A1 (fr) 1980-02-25
HU178166B (en) 1982-03-28
PH15882A (en) 1983-04-13
IE782146L (en) 1979-04-28
FR2407000B1 (fr) 1983-01-21
FI63674C (fi) 1983-08-10
DK479578A (da) 1979-04-29
IT1107570B (it) 1985-11-25
FI783269A (fi) 1979-04-29
GR73991B (fr) 1984-06-06
DE2845745A1 (de) 1979-05-10
DK154327C (da) 1989-04-03
NO149611C (no) 1984-05-23
NL7810753A (nl) 1979-05-02
JPS5480408A (en) 1979-06-27
ES474611A1 (es) 1980-01-16
JPS6231694B2 (fr) 1987-07-09
DK154327B (da) 1988-11-07
IT7851621A0 (it) 1978-10-24
AU520902B2 (en) 1982-03-04
GB2007244B (en) 1982-03-31
NO783635L (no) 1979-05-02
SE7811192L (sv) 1979-04-29
AR218932A1 (es) 1980-07-15
IL55433A (en) 1982-09-30
BE871586A (fr) 1979-04-27
GB2007244A (en) 1979-05-16
FR2407000A1 (fr) 1979-05-25
CA1117866A (fr) 1982-02-09
YU250878A (en) 1983-12-31
FI63674B (fi) 1983-04-29

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee