DE2809794A1 - Verfahren zur erhoehung des anteils an einem gewuenschten enantiomeren einer 2-arylpropionsaeure - Google Patents

Verfahren zur erhoehung des anteils an einem gewuenschten enantiomeren einer 2-arylpropionsaeure

Info

Publication number
DE2809794A1
DE2809794A1 DE19782809794 DE2809794A DE2809794A1 DE 2809794 A1 DE2809794 A1 DE 2809794A1 DE 19782809794 DE19782809794 DE 19782809794 DE 2809794 A DE2809794 A DE 2809794A DE 2809794 A1 DE2809794 A1 DE 2809794A1
Authority
DE
Germany
Prior art keywords
salt
propionic acid
ethylamine
diluent
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782809794
Other languages
German (de)
English (en)
Other versions
DE2809794C2 (fi
Inventor
John Stuart Nicholson
James Gordon Tantum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9697/77A external-priority patent/GB1596032A/en
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of DE2809794A1 publication Critical patent/DE2809794A1/de
Application granted granted Critical
Publication of DE2809794C2 publication Critical patent/DE2809794C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19782809794 1977-03-08 1978-03-07 Verfahren zur erhoehung des anteils an einem gewuenschten enantiomeren einer 2-arylpropionsaeure Granted DE2809794A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9697/77A GB1596032A (en) 1977-03-08 1977-03-08 Resolution of optically active 2-arylpropionic acids
GB194678 1978-01-18

Publications (2)

Publication Number Publication Date
DE2809794A1 true DE2809794A1 (de) 1978-09-21
DE2809794C2 DE2809794C2 (fi) 1989-08-03

Family

ID=26237091

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782809794 Granted DE2809794A1 (de) 1977-03-08 1978-03-07 Verfahren zur erhoehung des anteils an einem gewuenschten enantiomeren einer 2-arylpropionsaeure

Country Status (29)

Country Link
JP (1) JPS53112841A (fi)
AT (1) AT360508B (fi)
AU (1) AU521708B2 (fi)
BG (1) BG28567A3 (fi)
CA (1) CA1105942A (fi)
CH (1) CH638482A5 (fi)
CS (1) CS222255B2 (fi)
DD (1) DD136261A5 (fi)
DE (1) DE2809794A1 (fi)
DK (1) DK154418C (fi)
EG (1) EG13345A (fi)
ES (1) ES467606A1 (fi)
FI (1) FI66828C (fi)
FR (1) FR2383155A1 (fi)
GR (1) GR64816B (fi)
HU (1) HU178810B (fi)
IE (1) IE46476B1 (fi)
IN (1) IN147834B (fi)
IT (1) IT1202818B (fi)
LU (1) LU79186A1 (fi)
NL (1) NL189126C (fi)
NO (1) NO146197C (fi)
NZ (1) NZ186644A (fi)
PH (1) PH13333A (fi)
PL (1) PL110888B1 (fi)
PT (1) PT67743A (fi)
SE (1) SE436422B (fi)
SU (1) SU784759A3 (fi)
YU (1) YU41472B (fi)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006187A1 (de) * 1978-06-20 1980-01-09 Bayer Ag Enantiomerentrennung von chiralen Carbonsäuren
EP0060466A1 (en) * 1981-03-06 1982-09-22 Sumitomo Chemical Company, Limited Method for optical resolution of 2-(4-chlorophenyl)-3-methyl-butanoic acid
EP0362476A2 (de) * 1988-07-19 1990-04-11 Paz Arzneimittel- Entwicklungsgesellschaft Mbh Verfahren zur Trennung von Gemischen enantiomerer Arylpropionsäuren
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
DE4319438C1 (de) * 1993-06-11 1994-06-01 Gerd Dr Dr Geislinger Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren
WO1998049124A1 (de) * 1997-04-25 1998-11-05 Bayer Aktiengesellschaft Herstellung enantiomerenreiner biarylketocarbonsäuren
WO2010089343A1 (en) 2009-02-06 2010-08-12 Dsm Ip Assets B.V. Method for the synthesis of chiral alpha-aryl propionic acid derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH15674A (en) * 1979-07-06 1983-03-11 Syntex Corp Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
JPH01126425U (fi) * 1988-02-23 1989-08-29
JP3782834B2 (ja) 1994-10-26 2006-06-07 株式会社トクホン 鎮痛抗炎症貼付剤

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23268A (en) * 1964-05-07 1969-02-27 Merck & Co Inc Anti-inflammatory preparations containing the 4-phenyl-alpha-methyl acid acetic phenyl acid
FR2015728A1 (en) * 1968-04-18 1970-04-30 Lilly Co Eli Anti-inflammatory substd-phenylalkanoic acids and - derivs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BÄHR, W. - THEOBALD, H.: Organische Stereochemie, Springer-Verlag, Berlin, Heidelberg, New York 1973, S. 10-11 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006187A1 (de) * 1978-06-20 1980-01-09 Bayer Ag Enantiomerentrennung von chiralen Carbonsäuren
EP0060466A1 (en) * 1981-03-06 1982-09-22 Sumitomo Chemical Company, Limited Method for optical resolution of 2-(4-chlorophenyl)-3-methyl-butanoic acid
EP0362476A2 (de) * 1988-07-19 1990-04-11 Paz Arzneimittel- Entwicklungsgesellschaft Mbh Verfahren zur Trennung von Gemischen enantiomerer Arylpropionsäuren
EP0362476A3 (de) * 1988-07-19 1992-05-20 Paz Arzneimittel- Entwicklungsgesellschaft Mbh Verfahren zur Trennung von Gemischen enantiomerer Arylpropionsäuren
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
WO1992004018A1 (de) * 1990-09-12 1992-03-19 P A Z Arzneimittelentwicklungsgesellschaft Gmbh Arzneimittel sowie deren herstellung und deren verwendung bei der bekämpfung von schmerzen und/oder entzündungen an tieren und menschen
EP0607128B1 (de) * 1990-09-12 1997-09-17 Paz Arzneimittel- Entwicklungsgesellschaft Mbh Arzneimittel sowie deren herstellung und deren verwendung bei der bekämpfung von schmerzen und/oder entzündungen an tieren und menschen
DE4319438C1 (de) * 1993-06-11 1994-06-01 Gerd Dr Dr Geislinger Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren
WO1998049124A1 (de) * 1997-04-25 1998-11-05 Bayer Aktiengesellschaft Herstellung enantiomerenreiner biarylketocarbonsäuren
US6172259B1 (en) 1997-04-25 2001-01-09 Bayer Aktiengesellschaft Production of enantiomer-free biarylketocarboxylic acids
WO2010089343A1 (en) 2009-02-06 2010-08-12 Dsm Ip Assets B.V. Method for the synthesis of chiral alpha-aryl propionic acid derivatives

Also Published As

Publication number Publication date
NO146197C (no) 1982-08-18
FI66828B (fi) 1984-08-31
IE780467L (en) 1978-09-08
DE2809794C2 (fi) 1989-08-03
DK154418B (da) 1988-11-14
YU54078A (en) 1984-04-30
DK100878A (da) 1978-09-09
JPS626536B2 (fi) 1987-02-12
NL7802520A (nl) 1978-09-12
ES467606A1 (es) 1978-10-16
AT360508B (de) 1981-01-12
NZ186644A (en) 1980-10-24
PH13333A (en) 1980-03-13
CH638482A5 (en) 1983-09-30
EG13345A (en) 1981-06-30
SE7802603L (sv) 1978-09-09
AU3397778A (en) 1979-09-13
FI780738A (fi) 1978-09-09
IT1202818B (it) 1989-02-09
PL110888B1 (en) 1980-08-30
IT7848320A0 (it) 1978-03-07
FI66828C (fi) 1984-12-10
IN147834B (fi) 1980-07-19
NO780785L (no) 1978-09-11
BG28567A3 (bg) 1980-05-15
GR64816B (en) 1980-06-03
YU41472B (en) 1987-08-31
CS222255B2 (en) 1983-06-24
DK154418C (da) 1989-06-19
IE46476B1 (en) 1983-06-29
CA1105942A (en) 1981-07-28
NL189126C (nl) 1993-01-18
SU784759A3 (ru) 1980-11-30
SE436422B (sv) 1984-12-10
ATA163478A (de) 1980-06-15
LU79186A1 (fr) 1978-09-18
PT67743A (en) 1978-04-01
NO146197B (no) 1982-05-10
NL189126B (nl) 1992-08-17
DD136261A5 (de) 1979-06-27
JPS53112841A (en) 1978-10-02
FR2383155B1 (fi) 1983-12-30
FR2383155A1 (fr) 1978-10-06
PL205161A1 (pl) 1979-03-26
AU521708B2 (en) 1982-04-29
HU178810B (en) 1982-06-28

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Legal Events

Date Code Title Description
8126 Change of the secondary classification

Free format text: C07C 59/68 A61K 31/19 C07C 57/58

8127 New person/name/address of the applicant

Owner name: THE BOOTS CO. PLC, NOTTINGHAM, GB

8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM.

D2 Grant after examination
8364 No opposition during term of opposition