DE2756226A1 - 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel - Google Patents

1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Info

Publication number
DE2756226A1
DE2756226A1 DE19772756226 DE2756226A DE2756226A1 DE 2756226 A1 DE2756226 A1 DE 2756226A1 DE 19772756226 DE19772756226 DE 19772756226 DE 2756226 A DE2756226 A DE 2756226A DE 2756226 A1 DE2756226 A1 DE 2756226A1
Authority
DE
Germany
Prior art keywords
methyl
compound according
cyano
methoxycarbonyl
formyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19772756226
Other languages
German (de)
English (en)
Inventor
Yoshinari Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE2756226A1 publication Critical patent/DE2756226A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
DE19772756226 1976-12-17 1977-12-16 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel Ceased DE2756226A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (1)

Publication Number Publication Date
DE2756226A1 true DE2756226A1 (de) 1978-06-29

Family

ID=10465031

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772756226 Ceased DE2756226A1 (de) 1976-12-17 1977-12-16 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel

Country Status (15)

Country Link
JP (1) JPS5948828B2 (sv)
AR (2) AR221478A1 (sv)
AT (1) AT367401B (sv)
AU (1) AU518206B2 (sv)
BE (1) BE861964A (sv)
CH (1) CH633266A5 (sv)
DE (1) DE2756226A1 (sv)
DK (2) DK563377A (sv)
ES (3) ES465137A1 (sv)
FR (1) FR2374307A1 (sv)
GB (1) GB1591089A (sv)
HU (1) HU176454B (sv)
NL (1) NL7714066A (sv)
SE (2) SE7714374L (sv)
ZA (1) ZA777532B (sv)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935772A1 (de) * 1978-09-08 1980-03-20 Fujisawa Pharmaceutical Co Dihydropyridinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE2940833A1 (de) * 1978-10-10 1980-04-30 Fujisawa Pharmaceutical Co 2-methyl-dihydropyridin-verbindung, verfahren zu ihrer herstellung und sie enthaltendes pharmazeutisches mittel
EP0026317A1 (de) * 1979-09-01 1981-04-08 Bayer Ag Optisch aktive 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0039863A1 (de) * 1980-05-13 1981-11-18 Bayer Ag 1,4-Dihydropyridine mit unterschiedlichen Substituenten in 2- und 6-Position, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
EP0063359A1 (en) * 1981-04-18 1982-10-27 Banyu Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives and processes for preparing the same
EP0161917A2 (en) * 1984-05-12 1985-11-21 Pfizer Limited Dihydropyridines
EP0226271A1 (en) * 1985-08-21 1987-06-24 GLAXO S.p.A. 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation
EP0242950A2 (en) * 1986-02-20 1987-10-28 GLAXO S.p.A. dihydropyridines, process for their preparation and their use as therapeutics

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
HU197881B (en) * 1982-08-06 1989-06-28 Banyu Pharma Co Ltd Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
FI862343A (fi) 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN103951608B (zh) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 尼伐地平晶型及其制备方法
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3905983A (en) * 1972-09-30 1975-09-16 Bayer Ag 3,5,6-Tricarboxy- and 2,3,5,6-tetracarboxy-1,4-dihydropyridine derivatives
DE2524277A1 (de) * 1974-06-04 1975-12-18 Ciba Geigy Ag Neue 1,4-dihydropyridine und verfahren zu ihrer herstellung
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
US3905983A (en) * 1972-09-30 1975-09-16 Bayer Ag 3,5,6-Tricarboxy- and 2,3,5,6-tetracarboxy-1,4-dihydropyridine derivatives
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2524277A1 (de) * 1974-06-04 1975-12-18 Ciba Geigy Ag Neue 1,4-dihydropyridine und verfahren zu ihrer herstellung

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935772A1 (de) * 1978-09-08 1980-03-20 Fujisawa Pharmaceutical Co Dihydropyridinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE2940833A1 (de) * 1978-10-10 1980-04-30 Fujisawa Pharmaceutical Co 2-methyl-dihydropyridin-verbindung, verfahren zu ihrer herstellung und sie enthaltendes pharmazeutisches mittel
EP0026317A1 (de) * 1979-09-01 1981-04-08 Bayer Ag Optisch aktive 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0039863A1 (de) * 1980-05-13 1981-11-18 Bayer Ag 1,4-Dihydropyridine mit unterschiedlichen Substituenten in 2- und 6-Position, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
EP0063359A1 (en) * 1981-04-18 1982-10-27 Banyu Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives and processes for preparing the same
EP0161917A2 (en) * 1984-05-12 1985-11-21 Pfizer Limited Dihydropyridines
EP0161917A3 (en) * 1984-05-12 1987-12-02 Pfizer Limited Dihydropyridines
EP0226271A1 (en) * 1985-08-21 1987-06-24 GLAXO S.p.A. 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation
EP0242950A2 (en) * 1986-02-20 1987-10-28 GLAXO S.p.A. dihydropyridines, process for their preparation and their use as therapeutics
EP0242950A3 (en) * 1986-02-20 1988-09-14 Glaxo S.P.A. Dihydropyridines, process for their preparation and their use as therapeutics

Also Published As

Publication number Publication date
ES474233A1 (es) 1979-11-01
AT367401B (de) 1982-07-12
AU518206B2 (en) 1981-09-17
SE8204312D0 (sv) 1982-07-13
DK172182A (da) 1982-04-16
ZA777532B (en) 1978-10-25
JPS5395977A (en) 1978-08-22
BE861964A (fr) 1978-06-16
FR2374307A1 (fr) 1978-07-13
NL7714066A (nl) 1978-06-20
ES465137A1 (es) 1979-01-01
AU3165777A (en) 1979-06-21
DK563377A (da) 1978-06-18
GB1591089A (en) 1981-06-10
SE8204312L (sv) 1982-07-13
FR2374307B1 (sv) 1981-02-13
AR221887A1 (es) 1981-03-31
JPS5948828B2 (ja) 1984-11-29
AR221478A1 (es) 1981-02-13
CH633266A5 (en) 1982-11-30
HU176454B (en) 1981-03-28
ES474234A1 (es) 1979-04-01
SE7714374L (sv) 1978-06-18
ATA901877A (de) 1981-11-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: TUERK, D., DIPL.-CHEM. DR.RER.NAT. GILLE, C., DIPL

8131 Rejection