AR221887A1 - Procedimiento para preparar compuestos de 6-ciano-4-4-fenil-2-alquil(c1-c4)1,4-dihidropiridinas - Google Patents

Procedimiento para preparar compuestos de 6-ciano-4-4-fenil-2-alquil(c1-c4)1,4-dihidropiridinas

Info

Publication number
AR221887A1
AR221887A1 AR277301A AR27730179A AR221887A1 AR 221887 A1 AR221887 A1 AR 221887A1 AR 277301 A AR277301 A AR 277301A AR 27730179 A AR27730179 A AR 27730179A AR 221887 A1 AR221887 A1 AR 221887A1
Authority
AR
Argentina
Prior art keywords
cyan
phenyl
alkyl
preparing
procedure
Prior art date
Application number
AR277301A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of AR221887A1 publication Critical patent/AR221887A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR277301A 1976-12-17 1979-07-13 Procedimiento para preparar compuestos de 6-ciano-4-4-fenil-2-alquil(c1-c4)1,4-dihidropiridinas AR221887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (1)

Publication Number Publication Date
AR221887A1 true AR221887A1 (es) 1981-03-31

Family

ID=10465031

Family Applications (2)

Application Number Title Priority Date Filing Date
AR270392A AR221478A1 (es) 1976-12-17 1977-12-16 Procedimiento para preparar compuestos de 4-fenil 6-hidroxialquil(c1-c4)-1,4-dihidropirimidinas y sus sales
AR277301A AR221887A1 (es) 1976-12-17 1979-07-13 Procedimiento para preparar compuestos de 6-ciano-4-4-fenil-2-alquil(c1-c4)1,4-dihidropiridinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR270392A AR221478A1 (es) 1976-12-17 1977-12-16 Procedimiento para preparar compuestos de 4-fenil 6-hidroxialquil(c1-c4)-1,4-dihidropirimidinas y sus sales

Country Status (15)

Country Link
JP (1) JPS5948828B2 (es)
AR (2) AR221478A1 (es)
AT (1) AT367401B (es)
AU (1) AU518206B2 (es)
BE (1) BE861964A (es)
CH (1) CH633266A5 (es)
DE (1) DE2756226A1 (es)
DK (2) DK563377A (es)
ES (3) ES465137A1 (es)
FR (1) FR2374307A1 (es)
GB (1) GB1591089A (es)
HU (1) HU176454B (es)
NL (1) NL7714066A (es)
SE (2) SE7714374L (es)
ZA (1) ZA777532B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
CA1267416A (en) 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH607848A5 (es) * 1974-06-04 1978-11-30 Bayer Ag
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
CH633266A5 (en) 1982-11-30
JPS5395977A (en) 1978-08-22
NL7714066A (nl) 1978-06-20
DK563377A (da) 1978-06-18
ES474234A1 (es) 1979-04-01
SE7714374L (sv) 1978-06-18
SE8204312L (sv) 1982-07-13
HU176454B (en) 1981-03-28
ATA901877A (de) 1981-11-15
ZA777532B (en) 1978-10-25
JPS5948828B2 (ja) 1984-11-29
DK172182A (da) 1982-04-16
AU3165777A (en) 1979-06-21
DE2756226A1 (de) 1978-06-29
AR221478A1 (es) 1981-02-13
AT367401B (de) 1982-07-12
FR2374307A1 (fr) 1978-07-13
ES474233A1 (es) 1979-11-01
ES465137A1 (es) 1979-01-01
FR2374307B1 (es) 1981-02-13
BE861964A (fr) 1978-06-16
SE8204312D0 (sv) 1982-07-13
GB1591089A (en) 1981-06-10
AU518206B2 (en) 1981-09-17

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