AT367401B - Verfahren zur herstellung von neuen 6-hydroxyalkyl-1,4-dihydropyridinverbindungen - Google Patents
Verfahren zur herstellung von neuen 6-hydroxyalkyl-1,4-dihydropyridinverbindungenInfo
- Publication number
- AT367401B AT367401B AT0901877A AT901877A AT367401B AT 367401 B AT367401 B AT 367401B AT 0901877 A AT0901877 A AT 0901877A AT 901877 A AT901877 A AT 901877A AT 367401 B AT367401 B AT 367401B
- Authority
- AT
- Austria
- Prior art keywords
- hydroxyalkyl
- producing new
- dihydropyridine compounds
- dihydropyridine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB52720/76A GB1591089A (en) | 1976-12-17 | 1976-12-17 | 1,4-dihydropyridine derivatives and process for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA901877A ATA901877A (de) | 1981-11-15 |
| AT367401B true AT367401B (de) | 1982-07-12 |
Family
ID=10465031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0901877A AT367401B (de) | 1976-12-17 | 1977-12-16 | Verfahren zur herstellung von neuen 6-hydroxyalkyl-1,4-dihydropyridinverbindungen |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5948828B2 (es) |
| AR (2) | AR221478A1 (es) |
| AT (1) | AT367401B (es) |
| AU (1) | AU518206B2 (es) |
| BE (1) | BE861964A (es) |
| CH (1) | CH633266A5 (es) |
| DE (1) | DE2756226A1 (es) |
| DK (2) | DK563377A (es) |
| ES (3) | ES465137A1 (es) |
| FR (1) | FR2374307A1 (es) |
| GB (1) | GB1591089A (es) |
| HU (1) | HU176454B (es) |
| NL (1) | NL7714066A (es) |
| SE (2) | SE7714374L (es) |
| ZA (1) | ZA777532B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
| CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
| DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
| DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JPS57175164A (en) * | 1981-04-18 | 1982-10-28 | Banyu Pharmaceut Co Ltd | 1,4-dihydropyridine derivative and its preparation |
| EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
| ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
| HU192166B (en) * | 1982-08-06 | 1987-05-28 | Banyu Pharma Co Ltd | Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives |
| GB8412208D0 (en) * | 1984-05-12 | 1984-06-20 | Pfizer Ltd | Quinolone inotropic agents |
| US4678796A (en) * | 1984-11-30 | 1987-07-07 | Warner-Lambert Company | 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
| FI862343A (fi) | 1985-06-17 | 1986-12-18 | Warner Lambert Co | Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar. |
| EP0226271B1 (en) * | 1985-08-21 | 1990-11-22 | GLAXO S.p.A. | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
| DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| FR2596760B1 (fr) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
| US4732898A (en) * | 1986-04-29 | 1988-03-22 | Warner-Lambert Company | 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
| JPS63115890A (ja) * | 1986-10-31 | 1988-05-20 | Nippon Shinyaku Co Ltd | ２位置換１，４−ジヒドロピリジン誘導体 |
| US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
| CN101987833B (zh) * | 2009-08-04 | 2014-07-30 | 北京利乐生制药科技有限公司 | 尼伐地平晶型及其制备方法 |
| CN103254122B (zh) * | 2013-06-19 | 2015-04-22 | 湖南师范大学 | 一种心血管药物尼伐地平的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1963188A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | Neue Cyanphenyl-1,4-dihydropyridinderivate |
| US3946027A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
| US3946028A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
| DE2248150A1 (de) * | 1972-09-30 | 1974-04-04 | Bayer Ag | Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| CH607848A5 (es) * | 1974-06-04 | 1978-11-30 | Bayer Ag | |
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1976
- 1976-12-17 GB GB52720/76A patent/GB1591089A/en not_active Expired
-
1977
- 1977-12-16 JP JP52152290A patent/JPS5948828B2/ja not_active Expired
- 1977-12-16 BE BE183553A patent/BE861964A/xx not_active IP Right Cessation
- 1977-12-16 AR AR270392A patent/AR221478A1/es active
- 1977-12-16 AU AU31657/77A patent/AU518206B2/en not_active Expired
- 1977-12-16 ES ES465137A patent/ES465137A1/es not_active Expired
- 1977-12-16 SE SE7714374A patent/SE7714374L/xx not_active Application Discontinuation
- 1977-12-16 DE DE19772756226 patent/DE2756226A1/de not_active Ceased
- 1977-12-16 CH CH1553477A patent/CH633266A5/de not_active IP Right Cessation
- 1977-12-16 HU HU77FU358A patent/HU176454B/hu unknown
- 1977-12-16 AT AT0901877A patent/AT367401B/de not_active IP Right Cessation
- 1977-12-16 FR FR7738126A patent/FR2374307A1/fr active Granted
- 1977-12-16 DK DK563377A patent/DK563377A/da not_active Application Discontinuation
- 1977-12-19 NL NL7714066A patent/NL7714066A/xx not_active Application Discontinuation
- 1977-12-19 ZA ZA00777532A patent/ZA777532B/xx unknown
-
1978
- 1978-10-16 ES ES474233A patent/ES474233A1/es not_active Expired
- 1978-10-16 ES ES474234A patent/ES474234A1/es not_active Expired
-
1979
- 1979-07-13 AR AR277301A patent/AR221887A1/es active
-
1982
- 1982-04-16 DK DK172182A patent/DK172182A/da active IP Right Grant
- 1982-07-13 SE SE8204312A patent/SE8204312L/sv not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU176454B (en) | 1981-03-28 |
| AU3165777A (en) | 1979-06-21 |
| SE8204312D0 (sv) | 1982-07-13 |
| FR2374307B1 (es) | 1981-02-13 |
| JPS5948828B2 (ja) | 1984-11-29 |
| GB1591089A (en) | 1981-06-10 |
| SE7714374L (sv) | 1978-06-18 |
| DE2756226A1 (de) | 1978-06-29 |
| CH633266A5 (en) | 1982-11-30 |
| FR2374307A1 (fr) | 1978-07-13 |
| ES474233A1 (es) | 1979-11-01 |
| AR221478A1 (es) | 1981-02-13 |
| ATA901877A (de) | 1981-11-15 |
| AR221887A1 (es) | 1981-03-31 |
| SE8204312L (sv) | 1982-07-13 |
| JPS5395977A (en) | 1978-08-22 |
| DK563377A (da) | 1978-06-18 |
| ES474234A1 (es) | 1979-04-01 |
| ZA777532B (en) | 1978-10-25 |
| BE861964A (fr) | 1978-06-16 |
| DK172182A (da) | 1982-04-16 |
| ES465137A1 (es) | 1979-01-01 |
| NL7714066A (nl) | 1978-06-20 |
| AU518206B2 (en) | 1981-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |