AU518206B2 - Derivatives of 4-phenyl 1, 4-dihydropyridine-3, 5-dicarboxylate - Google Patents
Derivatives of 4-phenyl 1, 4-dihydropyridine-3, 5-dicarboxylateInfo
- Publication number
- AU518206B2 AU518206B2 AU31657/77A AU3165777A AU518206B2 AU 518206 B2 AU518206 B2 AU 518206B2 AU 31657/77 A AU31657/77 A AU 31657/77A AU 3165777 A AU3165777 A AU 3165777A AU 518206 B2 AU518206 B2 AU 518206B2
- Authority
- AU
- Australia
- Prior art keywords
- dihydropyridine
- dicarboxylate
- phenyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB52720/76A GB1591089A (en) | 1976-12-17 | 1976-12-17 | 1,4-dihydropyridine derivatives and process for preparation thereof |
GBGB52720/76 | 1976-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3165777A AU3165777A (en) | 1979-06-21 |
AU518206B2 true AU518206B2 (en) | 1981-09-17 |
Family
ID=10465031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU31657/77A Expired AU518206B2 (en) | 1976-12-17 | 1977-12-16 | Derivatives of 4-phenyl 1, 4-dihydropyridine-3, 5-dicarboxylate |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5948828B2 (en) |
AR (2) | AR221478A1 (en) |
AT (1) | AT367401B (en) |
AU (1) | AU518206B2 (en) |
BE (1) | BE861964A (en) |
CH (1) | CH633266A5 (en) |
DE (1) | DE2756226A1 (en) |
DK (2) | DK563377A (en) |
ES (3) | ES465137A1 (en) |
FR (1) | FR2374307A1 (en) |
GB (1) | GB1591089A (en) |
HU (1) | HU176454B (en) |
NL (1) | NL7714066A (en) |
SE (2) | SE7714374L (en) |
ZA (1) | ZA777532B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
DE2935451A1 (en) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
DE3018259A1 (en) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
JPS57175164A (en) * | 1981-04-18 | 1982-10-28 | Banyu Pharmaceut Co Ltd | 1,4-dihydropyridine derivative and its preparation |
EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
HU192166B (en) * | 1982-08-06 | 1987-05-28 | Banyu Pharma Co Ltd | Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives |
GB8412208D0 (en) * | 1984-05-12 | 1984-06-20 | Pfizer Ltd | Quinolone inotropic agents |
US4678796A (en) * | 1984-11-30 | 1987-07-07 | Warner-Lambert Company | 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
FI862343A (en) | 1985-06-17 | 1986-12-18 | Warner Lambert Co | FRAME FOR THE PREPARATION OF THERAPEUTIC NETWORK 1,4-DIHYDROPYRIDIN INFOERING. |
EP0226271B1 (en) * | 1985-08-21 | 1990-11-22 | GLAXO S.p.A. | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
DE3544211A1 (en) * | 1985-12-13 | 1987-06-19 | Bayer Ag | NEW, FLUORINE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
IT1204460B (en) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | HETEROCYCLIC DERIVATIVES |
FR2596760B1 (en) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | DISSYMMETRIC DERIVATIVES OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID, METHODS OF PREPARATION AND THERAPEUTIC USE |
US4732898A (en) * | 1986-04-29 | 1988-03-22 | Warner-Lambert Company | 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
JPS63115890A (en) * | 1986-10-31 | 1988-05-20 | Nippon Shinyaku Co Ltd | 2-substituted 1,4-dihydropyridine derivative |
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
CN103951608B (en) * | 2009-08-04 | 2016-04-27 | 喜德生(苏州)医药科技有限公司 | Nilvadipine crystal formation and preparation method thereof |
CN103254122B (en) * | 2013-06-19 | 2015-04-22 | 湖南师范大学 | Preparation method of cardiovascular drug nilvadipine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1963188A1 (en) * | 1969-12-17 | 1971-06-24 | Bayer Ag | New cyanophenyl-1,4-dihydropyridine derivatives |
US3946028A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
DE2248150A1 (en) * | 1972-09-30 | 1974-04-04 | Bayer Ag | DIHYDROPYRIDINE POLYESTER, METHOD FOR MANUFACTURING AND USING THEM AS A MEDICINAL PRODUCT |
US3946027A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
DE2335466A1 (en) * | 1973-07-12 | 1975-01-30 | Bayer Ag | ALCOXY ALKYL-1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
CH607848A5 (en) * | 1974-06-04 | 1978-11-30 | Bayer Ag | |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1976
- 1976-12-17 GB GB52720/76A patent/GB1591089A/en not_active Expired
-
1977
- 1977-12-16 AU AU31657/77A patent/AU518206B2/en not_active Expired
- 1977-12-16 FR FR7738126A patent/FR2374307A1/en active Granted
- 1977-12-16 AR AR270392A patent/AR221478A1/en active
- 1977-12-16 DE DE19772756226 patent/DE2756226A1/en not_active Ceased
- 1977-12-16 JP JP52152290A patent/JPS5948828B2/en not_active Expired
- 1977-12-16 AT AT0901877A patent/AT367401B/en not_active IP Right Cessation
- 1977-12-16 HU HU77FU358A patent/HU176454B/en unknown
- 1977-12-16 ES ES465137A patent/ES465137A1/en not_active Expired
- 1977-12-16 CH CH1553477A patent/CH633266A5/en not_active IP Right Cessation
- 1977-12-16 DK DK563377A patent/DK563377A/en not_active Application Discontinuation
- 1977-12-16 BE BE183553A patent/BE861964A/en not_active IP Right Cessation
- 1977-12-16 SE SE7714374A patent/SE7714374L/en not_active Application Discontinuation
- 1977-12-19 NL NL7714066A patent/NL7714066A/en not_active Application Discontinuation
- 1977-12-19 ZA ZA00777532A patent/ZA777532B/en unknown
-
1978
- 1978-10-16 ES ES474234A patent/ES474234A1/en not_active Expired
- 1978-10-16 ES ES474233A patent/ES474233A1/en not_active Expired
-
1979
- 1979-07-13 AR AR277301A patent/AR221887A1/en active
-
1982
- 1982-04-16 DK DK172182A patent/DK172182A/en active IP Right Grant
- 1982-07-13 SE SE8204312A patent/SE8204312L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FR2374307A1 (en) | 1978-07-13 |
NL7714066A (en) | 1978-06-20 |
JPS5395977A (en) | 1978-08-22 |
AR221887A1 (en) | 1981-03-31 |
AR221478A1 (en) | 1981-02-13 |
CH633266A5 (en) | 1982-11-30 |
ATA901877A (en) | 1981-11-15 |
SE8204312D0 (en) | 1982-07-13 |
DK172182A (en) | 1982-04-16 |
BE861964A (en) | 1978-06-16 |
AU3165777A (en) | 1979-06-21 |
SE8204312L (en) | 1982-07-13 |
SE7714374L (en) | 1978-06-18 |
GB1591089A (en) | 1981-06-10 |
HU176454B (en) | 1981-03-28 |
JPS5948828B2 (en) | 1984-11-29 |
DE2756226A1 (en) | 1978-06-29 |
ZA777532B (en) | 1978-10-25 |
ES474234A1 (en) | 1979-04-01 |
ES474233A1 (en) | 1979-11-01 |
ES465137A1 (en) | 1979-01-01 |
DK563377A (en) | 1978-06-18 |
FR2374307B1 (en) | 1981-02-13 |
AT367401B (en) | 1982-07-12 |
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