SE8204312L - PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES

Info

Publication number
SE8204312L
SE8204312L SE8204312A SE8204312A SE8204312L SE 8204312 L SE8204312 L SE 8204312L SE 8204312 A SE8204312 A SE 8204312A SE 8204312 A SE8204312 A SE 8204312A SE 8204312 L SE8204312 L SE 8204312L
Authority
SE
Sweden
Prior art keywords
formula
dihydropyridine derivatives
preparing
procedure
compounds
Prior art date
Application number
SE8204312A
Other languages
Swedish (sv)
Other versions
SE8204312D0 (en
Inventor
Y Sato
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of SE8204312D0 publication Critical patent/SE8204312D0/en
Publication of SE8204312L publication Critical patent/SE8204312L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel 1,4-dihydropyridine derivatives of the formula: are prepared by eliminating water from compounds of the formula: which, for their part, are obtained from corresponding 2-methyl-1,4-dihydropyridines by reaction with hydroxylamine or with a salt thereof. R<1> denotes cyano or lower alkoxycarbonyl, R<2> and R<3> denote esterified carboxyl and R<4> denotes lower alkyl. The compounds have vasodilatory and hypotensive effects and can be used in the form of pharmaceutical preparations for treating high blood pressure and cardiovascular diseases.

Claims (1)

PATENTKRAVPATENT REQUIREMENTS 1. FOrfarande for framstgllning av en forening med formeln 1-5: van i R1, 2, 11 och R4e vardera liar ovan angiven betydelse och 5b Sr lggre alkanoyl, med ett reduktionsmedel. van i R1 Sr cyano, lagre alkoxikarbonyl eller lagre alkansulfamoyl, R2 och R3 vardera Sr ldgre alkoxikarbonyl, lagre alkoxi(1dgre)alkoxikarbonyl, ar(lAgre)alkoxi(lOgre)alkoxikerbonyl eller aryloxi(lggre)alkoxikarbonyl, R4e Sr ldgre alkyl och R5e ir 1-hydroxi(lagre)alkyl, kgnnetecknat av att man omsatter en forening med formeln 1-2: R3A process for the preparation of a compound of formula 1-5: used in R 1, 2, 11 and R 4e each having the meaning given above and 5b being lower alkanoyl, with a reducing agent. R 1 is cyano, lower alkoxycarbonyl or lower alkanesulfamoyl, R 2 and R 3 are each S 1-hydroxy (lower) alkyl, characterized by reacting a compound of formula 1-2: R3
SE8204312A 1976-12-17 1982-07-13 PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES SE8204312L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (2)

Publication Number Publication Date
SE8204312D0 SE8204312D0 (en) 1982-07-13
SE8204312L true SE8204312L (en) 1982-07-13

Family

ID=10465031

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7714374A SE7714374L (en) 1976-12-17 1977-12-16 1,4-DIHYDROPYRIDINE COMPOUNDS
SE8204312A SE8204312L (en) 1976-12-17 1982-07-13 PROCEDURE FOR PREPARING 1,4-DIHYDROPYRIDINE DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7714374A SE7714374L (en) 1976-12-17 1977-12-16 1,4-DIHYDROPYRIDINE COMPOUNDS

Country Status (15)

Country Link
JP (1) JPS5948828B2 (en)
AR (2) AR221478A1 (en)
AT (1) AT367401B (en)
AU (1) AU518206B2 (en)
BE (1) BE861964A (en)
CH (1) CH633266A5 (en)
DE (1) DE2756226A1 (en)
DK (2) DK563377A (en)
ES (3) ES465137A1 (en)
FR (1) FR2374307A1 (en)
GB (1) GB1591089A (en)
HU (1) HU176454B (en)
NL (1) NL7714066A (en)
SE (2) SE7714374L (en)
ZA (1) ZA777532B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE2935451A1 (en) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE3018259A1 (en) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
CA1267416A (en) 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
DE3544211A1 (en) * 1985-12-13 1987-06-19 Bayer Ag NEW, FLUORINE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
IT1204460B (en) * 1986-02-20 1989-03-01 Glaxo Spa HETEROCYCLIC DERIVATIVES
FR2596760B1 (en) * 1986-04-02 1988-12-09 Sori Soc Rech Ind DISSYMMETRIC DERIVATIVES OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID, METHODS OF PREPARATION AND THERAPEUTIC USE
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (en) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivative
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN103951608B (en) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 Nilvadipine crystal formation and preparation method thereof
CN103254122B (en) * 2013-06-19 2015-04-22 湖南师范大学 Preparation method of cardiovascular drug nilvadipine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (en) * 1969-12-17 1971-06-24 Bayer Ag New cyanophenyl-1,4-dihydropyridine derivatives
DE2248150A1 (en) * 1972-09-30 1974-04-04 Bayer Ag DIHYDROPYRIDINE POLYESTER, METHOD FOR MANUFACTURING AND USING THEM AS A MEDICINAL PRODUCT
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2335466A1 (en) * 1973-07-12 1975-01-30 Bayer Ag ALCOXY ALKYL-1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
CH607848A5 (en) * 1974-06-04 1978-11-30 Bayer Ag
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
AU3165777A (en) 1979-06-21
DK563377A (en) 1978-06-18
ATA901877A (en) 1981-11-15
DE2756226A1 (en) 1978-06-29
AR221887A1 (en) 1981-03-31
SE8204312D0 (en) 1982-07-13
JPS5948828B2 (en) 1984-11-29
JPS5395977A (en) 1978-08-22
AT367401B (en) 1982-07-12
DK172182A (en) 1982-04-16
NL7714066A (en) 1978-06-20
SE7714374L (en) 1978-06-18
ES474233A1 (en) 1979-11-01
BE861964A (en) 1978-06-16
ES474234A1 (en) 1979-04-01
ES465137A1 (en) 1979-01-01
AU518206B2 (en) 1981-09-17
FR2374307A1 (en) 1978-07-13
ZA777532B (en) 1978-10-25
GB1591089A (en) 1981-06-10
AR221478A1 (en) 1981-02-13
CH633266A5 (en) 1982-11-30
FR2374307B1 (en) 1981-02-13
HU176454B (en) 1981-03-28

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