GB1591089A - 1,4-dihydropyridine derivatives and process for preparation thereof - Google Patents

1,4-dihydropyridine derivatives and process for preparation thereof Download PDF

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Publication number
GB1591089A
GB1591089A GB52720/76A GB5272076A GB1591089A GB 1591089 A GB1591089 A GB 1591089A GB 52720/76 A GB52720/76 A GB 52720/76A GB 5272076 A GB5272076 A GB 5272076A GB 1591089 A GB1591089 A GB 1591089A
Authority
GB
United Kingdom
Prior art keywords
methyl
compound according
methoxycarbonyl
cyano
formyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52720/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA256,210A priority Critical patent/CA1080223A/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to GB52720/76A priority patent/GB1591089A/en
Priority to MX689277U priority patent/MX5273E/es
Priority to CH1553477A priority patent/CH633266A5/de
Priority to AR270392A priority patent/AR221478A1/es
Priority to ES465137A priority patent/ES465137A1/es
Priority to SE7714374A priority patent/SE7714374L/sv
Priority to HU77FU358A priority patent/HU176454B/hu
Priority to DE19772756226 priority patent/DE2756226A1/de
Priority to FR7738126A priority patent/FR2374307A1/fr
Priority to AT0901877A priority patent/AT367401B/de
Priority to DK563377A priority patent/DK563377A/da
Priority to BE183553A priority patent/BE861964A/xx
Priority to AU31657/77A priority patent/AU518206B2/en
Priority to JP52152290A priority patent/JPS5948828B2/ja
Priority to ZA00777532A priority patent/ZA777532B/xx
Priority to NL7714066A priority patent/NL7714066A/xx
Priority to ES474233A priority patent/ES474233A1/es
Priority to ES474234A priority patent/ES474234A1/es
Priority to US06/039,752 priority patent/US4284634A/en
Priority to AR277301A priority patent/AR221887A1/es
Priority to AT272280A priority patent/AT367402B/de
Priority to US06/180,905 priority patent/US4338322A/en
Priority to US06/213,048 priority patent/US4370334A/en
Publication of GB1591089A publication Critical patent/GB1591089A/en
Priority to DK172182A priority patent/DK172182A/da
Priority to SE8204312A priority patent/SE8204312L/sv
Priority to US06/414,842 priority patent/US4525478A/en
Priority to CH632682A priority patent/CH638785A5/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB52720/76A 1975-07-02 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof Expired GB1591089A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
CA256,210A CA1080223A (en) 1975-07-02 1976-07-02 1,4-dihydropyridine derivatives, process for preparation thereof and pharmaceutical composition of the same
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof
MX689277U MX5273E (es) 1976-12-17 1977-12-15 Procedimiento para preparar derivados de la 4-fenil-1,4-dihidropiridina
AU31657/77A AU518206B2 (en) 1976-12-17 1977-12-16 Derivatives of 4-phenyl 1, 4-dihydropyridine-3, 5-dicarboxylate
AR270392A AR221478A1 (es) 1976-12-17 1977-12-16 Procedimiento para preparar compuestos de 4-fenil 6-hidroxialquil(c1-c4)-1,4-dihidropirimidinas y sus sales
ES465137A ES465137A1 (es) 1976-12-17 1977-12-16 Un procedimiento para preparar compuestos de 6-hidroxialco- hil-1,4-dihidropiridina
SE7714374A SE7714374L (sv) 1976-12-17 1977-12-16 1,4-dihydropyridinforbindelser
HU77FU358A HU176454B (en) 1976-12-17 1977-12-16 Process for preparing 1,4-dihydro-pyridine derivatives
DE19772756226 DE2756226A1 (de) 1976-12-17 1977-12-16 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
FR7738126A FR2374307A1 (fr) 1976-12-17 1977-12-16 Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
AT0901877A AT367401B (de) 1976-12-17 1977-12-16 Verfahren zur herstellung von neuen 6-hydroxyalkyl-1,4-dihydropyridinverbindungen
DK563377A DK563377A (da) 1976-12-17 1977-12-16 R fremgangsmaade til fremstilling af 1,4-dihydropyridinderivate
BE183553A BE861964A (fr) 1976-12-17 1977-12-16 Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
CH1553477A CH633266A5 (en) 1976-12-17 1977-12-16 Process for preparing 1,4-dihydropyridine compounds
JP52152290A JPS5948828B2 (ja) 1976-12-17 1977-12-16 １．４↓−ジヒドロピリジン化合物およびその製造法
NL7714066A NL7714066A (nl) 1976-12-17 1977-12-19 1.4-dihydropyridineverbindingen, werkwijze voor de bereiding daarvan en farmaceutische prepara- ten, die deze verbindingen bevatten.
ZA00777532A ZA777532B (en) 1976-12-17 1977-12-19 1,4-dihydropyridine compounds,process for preparation thereof and pharmaceutical composition of the same
ES474233A ES474233A1 (es) 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina
ES474234A ES474234A1 (es) 1976-12-17 1978-10-16 Un procedimiento para preparar compuestos de 1,4-dihidropi- ridina sustituidos en posicion 6
US06/039,752 US4284634A (en) 1975-07-02 1979-05-17 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
AR277301A AR221887A1 (es) 1976-12-17 1979-07-13 Procedimiento para preparar compuestos de 6-ciano-4-4-fenil-2-alquil(c1-c4)1,4-dihidropiridinas
AT272280A AT367402B (de) 1976-12-17 1980-05-21 Verfahren zur herstellung von neuen 1,4dihydropyridinverbindungen
US06/180,905 US4338322A (en) 1975-07-02 1980-08-25 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same
US06/213,048 US4370334A (en) 1975-07-02 1980-12-04 1,4-Dihydro-pyridine derivatives and methods of using same
DK172182A DK172182A (da) 1976-12-17 1982-04-16 Fremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
SE8204312A SE8204312L (sv) 1976-12-17 1982-07-13 Forfarande for framstellning av 1,4-dihydropyridinderivat
US06/414,842 US4525478A (en) 1975-07-02 1982-09-03 Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties
CH632682A CH638785A5 (en) 1976-12-17 1982-10-29 Process for the preparation of 1,4-dihydropyridine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (1)

Publication Number Publication Date
GB1591089A true GB1591089A (en) 1981-06-10

Family

ID=10465031

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52720/76A Expired GB1591089A (en) 1975-07-02 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Country Status (15)

Country Link
JP (1) JPS5948828B2 (sv)
AR (2) AR221478A1 (sv)
AT (1) AT367401B (sv)
AU (1) AU518206B2 (sv)
BE (1) BE861964A (sv)
CH (1) CH633266A5 (sv)
DE (1) DE2756226A1 (sv)
DK (2) DK563377A (sv)
ES (3) ES465137A1 (sv)
FR (1) FR2374307A1 (sv)
GB (1) GB1591089A (sv)
HU (1) HU176454B (sv)
NL (1) NL7714066A (sv)
SE (2) SE7714374L (sv)
ZA (1) ZA777532B (sv)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080220A1 (en) * 1981-11-17 1983-06-01 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
EP0101023A1 (en) * 1982-08-06 1984-02-22 Banyu Pharmaceutical Co., Ltd. Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
GB2196631A (en) * 1986-10-31 1988-05-05 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivatives
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN101987833A (zh) * 2009-08-04 2011-03-23 北京利乐生制药科技有限公司 尼伐地平新晶型及其制备方法
CN103254122A (zh) * 2013-06-19 2013-08-21 湖南师范大学 一种心血管药物尼伐地平的制备方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
CA1267416A (en) 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH607848A5 (sv) * 1974-06-04 1978-11-30 Bayer Ag
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080220A1 (en) * 1981-11-17 1983-06-01 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
EP0101023A1 (en) * 1982-08-06 1984-02-22 Banyu Pharmaceutical Co., Ltd. Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
GB2196631A (en) * 1986-10-31 1988-05-05 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivatives
GB2196631B (en) * 1986-10-31 1990-07-11 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivatives
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN101987833A (zh) * 2009-08-04 2011-03-23 北京利乐生制药科技有限公司 尼伐地平新晶型及其制备方法
CN103951608A (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
CN103951608B (zh) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 尼伐地平晶型及其制备方法
CN103254122A (zh) * 2013-06-19 2013-08-21 湖南师范大学 一种心血管药物尼伐地平的制备方法

Also Published As

Publication number Publication date
BE861964A (fr) 1978-06-16
ZA777532B (en) 1978-10-25
ATA901877A (de) 1981-11-15
ES474233A1 (es) 1979-11-01
AT367401B (de) 1982-07-12
AR221478A1 (es) 1981-02-13
CH633266A5 (en) 1982-11-30
HU176454B (en) 1981-03-28
JPS5395977A (en) 1978-08-22
SE7714374L (sv) 1978-06-18
FR2374307A1 (fr) 1978-07-13
SE8204312D0 (sv) 1982-07-13
AU3165777A (en) 1979-06-21
DE2756226A1 (de) 1978-06-29
ES465137A1 (es) 1979-01-01
ES474234A1 (es) 1979-04-01
FR2374307B1 (sv) 1981-02-13
AU518206B2 (en) 1981-09-17
DK563377A (da) 1978-06-18
NL7714066A (nl) 1978-06-20
DK172182A (da) 1982-04-16
AR221887A1 (es) 1981-03-31
JPS5948828B2 (ja) 1984-11-29
SE8204312L (sv) 1982-07-13

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Legal Events

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PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee