DE2748520C2 - - Google Patents

Info

Publication number
DE2748520C2
DE2748520C2 DE19772748520 DE2748520A DE2748520C2 DE 2748520 C2 DE2748520 C2 DE 2748520C2 DE 19772748520 DE19772748520 DE 19772748520 DE 2748520 A DE2748520 A DE 2748520A DE 2748520 C2 DE2748520 C2 DE 2748520C2
Authority
DE
Germany
Prior art keywords
dane particles
liquid
gradient
density gradient
dane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19772748520
Other languages
German (de)
English (en)
Other versions
DE2748520A1 (de
Inventor
William J Mcaleer
Edward H Wasmuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/784,191 external-priority patent/US4129646A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2748520A1 publication Critical patent/DE2748520A1/de
Application granted granted Critical
Publication of DE2748520C2 publication Critical patent/DE2748520C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19772748520 1976-11-02 1977-10-28 Hepatitis b-dane-teilchen Granted DE2748520A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73786276A 1976-11-02 1976-11-02
US05/784,191 US4129646A (en) 1976-11-02 1977-04-04 Isolating hepatitis B Dane particles

Publications (2)

Publication Number Publication Date
DE2748520A1 DE2748520A1 (de) 1978-05-03
DE2748520C2 true DE2748520C2 (xx) 1987-07-30

Family

ID=27113269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772748520 Granted DE2748520A1 (de) 1976-11-02 1977-10-28 Hepatitis b-dane-teilchen

Country Status (5)

Country Link
JP (1) JPS5379011A (xx)
DE (1) DE2748520A1 (xx)
FR (3) FR2394297A1 (xx)
GB (2) GB1554400A (xx)
NL (1) NL7711378A (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102996A (en) * 1977-04-20 1978-07-25 Merck & Co., Inc. Method of preparing hepatitis B core antigen
DK366778A (da) * 1978-08-18 1980-02-19 Foss Electric As Fremgangsmaade til taelling af bakterier
DE3049690A1 (de) * 1979-07-05 1982-02-18 Alpha Therapeutic Corp Process for producing hepatitis b vaccine
DE3150935A1 (de) * 1981-12-23 1983-06-30 Uwe Dr.med. 3400 Göttingen Böttcher Verfahren zur herstellung eines hepatitis-b impfstoffes
EP0114291A3 (de) * 1983-01-24 1985-12-04 Bodo Dr. Plewinsky Mittel zur Trennung gelöster und/oder ungelöster Stoffe aufgrund unterschiedlicher Auftriebsdichten bzw. Dichten vermittels der Lösungen echter Metawolframate
FR2561256B1 (fr) * 1984-03-16 1987-01-02 Pasteur Institut Procede de purification de particules biologiques de type antigene hbs, par ultracentrifugation de flottation sur gradient de densite

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356413A (en) * 1971-09-09 1974-06-12 Pfizer Ltd Method of obtaining purified australia antigen from blood serum
US4029764A (en) * 1974-12-09 1977-06-14 Merck & Co., Inc. Hepatitis A antigen
US4024243A (en) * 1975-06-16 1977-05-17 Merck & Co., Inc. Process for isolating hepatitis B antigen
FR2412315A1 (fr) * 1977-02-23 1979-07-20 Merck & Co Inc Procede de preparation d'un antigene de l'hepatite b et l'antigene obtenu
GB1554811A (en) * 1977-02-23 1979-10-31 Merck & Co Inc Purifying hepatitis b surface antigen

Also Published As

Publication number Publication date
FR2394297A1 (fr) 1979-01-12
NL7711378A (nl) 1978-05-05
JPS635381B2 (xx) 1988-02-03
FR2422399A1 (fr) 1979-11-09
FR2422406A1 (fr) 1979-11-09
JPS5379011A (en) 1978-07-13
FR2394297B1 (xx) 1982-11-19
DE2748520A1 (de) 1978-05-03
FR2422406B1 (xx) 1982-11-19
FR2422399B1 (xx) 1982-11-19
GB1554399A (en) 1979-10-17
GB1554400A (en) 1979-10-17

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee