DE2731292A1 - 2-eckige klammer auf 3-(2-thiazolylthio)-phenyl eckige klammer zu -alkansaeuren und verfahren zu ihrer herstellung - Google Patents

2-eckige klammer auf 3-(2-thiazolylthio)-phenyl eckige klammer zu -alkansaeuren und verfahren zu ihrer herstellung

Info

Publication number
DE2731292A1
DE2731292A1 DE19772731292 DE2731292A DE2731292A1 DE 2731292 A1 DE2731292 A1 DE 2731292A1 DE 19772731292 DE19772731292 DE 19772731292 DE 2731292 A DE2731292 A DE 2731292A DE 2731292 A1 DE2731292 A1 DE 2731292A1
Authority
DE
Germany
Prior art keywords
phenyl
acid
thiazolylthio
mercaptophenyl
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772731292
Other languages
German (de)
English (en)
Inventor
Norman Peter Jensen
David Harry Minsker
Tsung-Ying Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2731292A1 publication Critical patent/DE2731292A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE19772731292 1976-07-12 1977-07-11 2-eckige klammer auf 3-(2-thiazolylthio)-phenyl eckige klammer zu -alkansaeuren und verfahren zu ihrer herstellung Withdrawn DE2731292A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70486376A 1976-07-12 1976-07-12

Publications (1)

Publication Number Publication Date
DE2731292A1 true DE2731292A1 (de) 1978-01-19

Family

ID=24831153

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772731292 Withdrawn DE2731292A1 (de) 1976-07-12 1977-07-11 2-eckige klammer auf 3-(2-thiazolylthio)-phenyl eckige klammer zu -alkansaeuren und verfahren zu ihrer herstellung

Country Status (7)

Country Link
JP (1) JPS539765A (enExample)
DE (1) DE2731292A1 (enExample)
DK (1) DK287977A (enExample)
FR (1) FR2358402A1 (enExample)
GB (1) GB1543276A (enExample)
NL (1) NL7707161A (enExample)
SE (1) SE7707451L (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015117146A1 (en) 2014-02-03 2015-08-06 Quadriga Biosciences, Inc. Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents
US9394237B2 (en) 2014-02-03 2016-07-19 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents
US9783487B2 (en) 2015-08-03 2017-10-10 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10224463A1 (de) 2002-06-03 2003-12-11 Bayer Ag Verfahren zur Herstellung von 5-Nitro-3,4-dihydro-1(2H)-naphthalinon, 1,5-Naphthalindiamin und 1,5-Naphthalindiisocyanat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890337A (en) * 1973-11-23 1975-06-17 Lilly Co Eli {60 ,{60 ,{60 -Trifluoro-2-nitro-6-{8 oxa(thia)zolyl{9 thio-p-tolunitriles

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015117146A1 (en) 2014-02-03 2015-08-06 Quadriga Biosciences, Inc. Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents
US9394237B2 (en) 2014-02-03 2016-07-19 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents
US9394236B2 (en) 2014-02-03 2016-07-19 Quadriga Biosciences, Inc. β-substituted γ-amino acids and analogs as chemotherapeutic agents
US9682921B2 (en) 2014-02-03 2017-06-20 Quadriga Biosciences, Inc. β-substituted γ-amino acids and analogs as chemotherapeutic agents
US9861599B2 (en) 2014-02-03 2018-01-09 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
US9937139B2 (en) 2014-02-03 2018-04-10 Quadriga Biosciences, Inc. β-substituted γ-amino acids and analogs as chemotherapeutic agents
US10034847B2 (en) 2014-02-03 2018-07-31 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
US10245246B2 (en) 2014-02-03 2019-04-02 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents
US9783487B2 (en) 2015-08-03 2017-10-10 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
US10017459B2 (en) 2015-08-03 2018-07-10 Quadriga Biosciences, Inc. β-substituted β-amino acids and analogs as chemotherapeutic agents and uses thereof
US10246406B2 (en) 2015-08-03 2019-04-02 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof

Also Published As

Publication number Publication date
FR2358402A1 (fr) 1978-02-10
SE7707451L (sv) 1978-01-13
JPS539765A (en) 1978-01-28
FR2358402B1 (enExample) 1980-02-29
GB1543276A (en) 1979-03-28
NL7707161A (nl) 1978-01-16
DK287977A (da) 1978-01-13

Similar Documents

Publication Publication Date Title
DE1668648C3 (de) 3-Benzoylphenylessigsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2532420A1 (de) Phenylessigsaeure-derivate und verfahren zu ihrer herstellung
DE2355084A1 (de) Verbindungen mit magensaeuresekretionshemmender wirkung und verfahren zu deren herstellung
CH631165A5 (de) Verfahren zur herstellung neuer pyrazol-derivate.
DE2731292A1 (de) 2-eckige klammer auf 3-(2-thiazolylthio)-phenyl eckige klammer zu -alkansaeuren und verfahren zu ihrer herstellung
CH653996A5 (de) Tryptaminderivate und verfahren zu deren herstellung.
DE1695633A1 (de) Verfahren zur Herstellung von neuen Phenoxazinderivaten
DE2241680A1 (de) 17-hydroxy-7-(niedr.alkoxy)carbonyl3-oxo-17alpha-pregn-4-en-21-carbonsaeuregamma-lactone, die ihnen zugrunde liegenden saeuren und ihre salze
CH623578A5 (enExample)
DE69308757T2 (de) 1-Phenybicyclo-2,2,2-oktanderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE1804328A1 (de) 3-substituierte Chinoxalinone und Verfahren zur Herstellung von 3-substituierten Chinoxalin-2-Onen
DE2215048A1 (de) Verfahren zur herstellung von 2eckige klammer auf bis-(4', 4"-dialkylamino)benzhydryl eckige klammer zu -5-aminobenzoesaeuren
AT284848B (de) Verfahren zur Herstellung 3-substituierter 1,2,3,4-Tetrahydro- bzw. 1,2-Dihydro-chinoxalin-2-one
AT354432B (de) Verfahren zur herstellung von 3-indolylessig- saeuren
DE1963824A1 (de) Verfahren zur Herstellung von 2-(3-Benzoyl-2-hydroxyphenyl)-propionsaeure
AT299169B (de) Verfahren zur Herstellung der neuen α-[p-(1-Cyclohexenyl)-phenyl]-propionsäure
DE1493567C3 (de) Ester von alpha-Alkylthyroxinderivaten und Verfahren zu ihrer Herstellung
DE2604560A1 (de) Phenylalkancarbonsaeure-derivate und verfahren zu ihrer herstellung
AT362353B (de) Verfahren zur herstellung von neuen in 4- -stellung substituierten 3-sulfamoyl-5-pyrrolyl - oder -5-pyrrolylalkylbenzoesaeuren und ihren salzen
AT227692B (de) Verfahren zur Herstellung von neuen optisch aktiven Indolbasen
AT215993B (de) Verfahren zur Herstellung von neuen 4-Oxo-2-(halogenalkyl)-2,3-dihydro-[benzo-1,3-oxazinen]
DE1950054C3 (de) alpha- eckige Klammer auf p-(l-Cyclohexenyl) -phenyl eckige Klammer zu -propionsäure, ihre Salze, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
AT205026B (de) Verfahren zur Herstellung von neuen α-Aroyl-α-(o-carboxybenzoylamino)-essigsäureestern
AT252912B (de) Verfahren zur Herstellung der 3-Methylflavon-8-carbonsäure und deren Estern
AT278787B (de) Verfahren zur herstellung von neuen carbonsaeuren und von deren salzen

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee