DE2724948A1 - Hydantoinderivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen - Google Patents

Hydantoinderivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen

Info

Publication number
DE2724948A1
DE2724948A1 DE19772724948 DE2724948A DE2724948A1 DE 2724948 A1 DE2724948 A1 DE 2724948A1 DE 19772724948 DE19772724948 DE 19772724948 DE 2724948 A DE2724948 A DE 2724948A DE 2724948 A1 DE2724948 A1 DE 2724948A1
Authority
DE
Germany
Prior art keywords
group
compound
general formula
radicals
hydantoin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19772724948
Other languages
German (de)
English (en)
Inventor
Albert Gordon Caldwell
Norman Whittaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE2724948A1 publication Critical patent/DE2724948A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19772724948 1976-06-03 1977-06-02 Hydantoinderivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen Ceased DE2724948A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2287776 1976-06-03
GB5034076 1976-12-02
GB1214577 1977-03-23

Publications (1)

Publication Number Publication Date
DE2724948A1 true DE2724948A1 (de) 1977-12-15

Family

ID=27256793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772724948 Ceased DE2724948A1 (de) 1976-06-03 1977-06-02 Hydantoinderivate, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen

Country Status (12)

Country Link
JP (1) JPS52151168A (da)
CA (1) CA1176261A (da)
CH (3) CH645631A5 (da)
DE (1) DE2724948A1 (da)
DK (1) DK244577A (da)
ES (5) ES459412A1 (da)
FI (1) FI71930C (da)
FR (1) FR2362839A1 (da)
HU (1) HU183046B (da)
NL (1) NL7706064A (da)
NZ (1) NZ184281A (da)
SE (2) SE446336B (da)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002259A2 (en) * 1977-12-01 1979-06-13 The Wellcome Foundation Limited Hydantoin derivatives and salts thereof, their synthesis and pharmaceutical formulations
EP0003410A1 (en) * 1978-01-23 1979-08-08 Beecham Group Plc Hydantoins and thiohydantoins, method for their preparation and pharmaceutical compositions containing them
EP0004723A1 (en) * 1978-03-30 1979-10-17 Beecham Group Plc Deoxyhydantoins, processes for their preparation and pharmaceutical compositions containing them
EP0006719A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Prostaglandin analogue imidazole derivatives, processes for their preparation and a pharmaceutical composition containing them
EP0006353A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Prostaglandin analogue imidazole derivatives, a process for their preparation and a pharmaceutical composition containing them
EP0006352A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Hydantoins and thiohydantoins, process for their preparation and pharmaceutical compositions containing them
EP0007180A1 (en) * 1978-06-15 1980-01-23 Beecham Group Plc Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them
EP0019223A1 (en) * 1979-05-09 1980-11-26 The Wellcome Foundation Limited Optically active hydantoin derivatives, their synthesis, pharmaceutical formulations containing them, and intermediates
US4413002A (en) * 1979-01-18 1983-11-01 Beecham Group Limited Bronchodilating hydantoin derivatives
WO2003048130A2 (en) * 2001-11-30 2003-06-12 Eli Lilly And Company Peroxisome proliferator activated receptor agonists

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602188A (en) * 1977-12-01 1981-11-11 Wellcome Found Hydantoin derivatives
JPS5463083A (en) * 1977-09-05 1979-05-21 Wellcome Found Organism active nitrogen compound
GB1599740A (en) * 1978-05-31 1981-10-07 Wellcome Found Hydantoin derivatives
US4684735A (en) * 1985-07-01 1987-08-04 Stauffer Chemical Company Promotion of raney nickel hydrogenation catalyst
JP3022878U (ja) * 1995-08-18 1996-04-02 有限会社春江加工 ミニディスク用ケース
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
WO2004108215A1 (en) * 2003-06-06 2004-12-16 Allergan, Inc. Piperidinyl prostaglandin e analogs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE835989A (fr) * 1974-11-29 1976-05-26 Amines et amides cycliques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE835989A (fr) * 1974-11-29 1976-05-26 Amines et amides cycliques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
THL, 34, 2931, 1975 *
THL, 49, 4463, 1976 *
THL, 49, 4467, 1976 *
THL=Tetrahedron Letters *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002259A3 (en) * 1977-12-01 1979-06-27 The Wellcome Foundation Limited Hydantoin derivatives and salts thereof, their synthesis and intermediates, and pharmaceutical formulations
EP0002259A2 (en) * 1977-12-01 1979-06-13 The Wellcome Foundation Limited Hydantoin derivatives and salts thereof, their synthesis and pharmaceutical formulations
US4298745A (en) * 1978-01-23 1981-11-03 Beecham Group Limited Hydantoin derivatives
EP0003410A1 (en) * 1978-01-23 1979-08-08 Beecham Group Plc Hydantoins and thiohydantoins, method for their preparation and pharmaceutical compositions containing them
EP0004723A1 (en) * 1978-03-30 1979-10-17 Beecham Group Plc Deoxyhydantoins, processes for their preparation and pharmaceutical compositions containing them
US4246273A (en) * 1978-03-30 1981-01-20 Beecham Group Limited 1,5-Disubstituted imidazolid-4-ones
EP0006719A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Prostaglandin analogue imidazole derivatives, processes for their preparation and a pharmaceutical composition containing them
EP0006353A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Prostaglandin analogue imidazole derivatives, a process for their preparation and a pharmaceutical composition containing them
EP0006352A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Hydantoins and thiohydantoins, process for their preparation and pharmaceutical compositions containing them
EP0007180A1 (en) * 1978-06-15 1980-01-23 Beecham Group Plc Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them
US4241074A (en) * 1978-06-15 1980-12-23 Beecham Group Limited Prostaglandin analogues
US4413002A (en) * 1979-01-18 1983-11-01 Beecham Group Limited Bronchodilating hydantoin derivatives
EP0019223A1 (en) * 1979-05-09 1980-11-26 The Wellcome Foundation Limited Optically active hydantoin derivatives, their synthesis, pharmaceutical formulations containing them, and intermediates
WO2003048130A2 (en) * 2001-11-30 2003-06-12 Eli Lilly And Company Peroxisome proliferator activated receptor agonists
WO2003048130A3 (en) * 2001-11-30 2003-11-20 Lilly Co Eli Peroxisome proliferator activated receptor agonists
US7544812B2 (en) 2001-11-30 2009-06-09 Eli Lilly And Company Peroxisome proliferator activated receptor agonists

Also Published As

Publication number Publication date
HU183046B (en) 1984-04-28
CA1176261A (en) 1984-10-16
SE8203161L (sv) 1982-05-19
ES482010A1 (es) 1980-08-16
NL7706064A (nl) 1977-12-06
CH645631A5 (en) 1984-10-15
FI771763A (fi) 1977-12-04
CH646426A5 (en) 1984-11-30
JPS6222986B2 (da) 1987-05-20
CH647511A5 (en) 1985-01-31
JPS52151168A (en) 1977-12-15
ES478156A1 (es) 1979-11-01
FR2362839A1 (fr) 1978-03-24
FI71930C (fi) 1987-03-09
FI71930B (fi) 1986-11-28
DK244577A (da) 1977-12-04
SE7706428L (sv) 1977-12-04
NZ184281A (en) 1980-04-28
ES459412A1 (es) 1978-11-01
ES8103057A1 (es) 1981-02-16
ES470428A1 (es) 1979-09-01
FR2362839B1 (da) 1980-02-01
SE446336B (sv) 1986-09-01
ES489883A0 (es) 1981-02-16

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection