DE2700338C2 - Parenteral injizierbarer Impfstoff für Schweine gegen Infektionen von Bordetella bronchiseptica sowie Verfahren zum Herstellen dieses Impfstoffes - Google Patents
Parenteral injizierbarer Impfstoff für Schweine gegen Infektionen von Bordetella bronchiseptica sowie Verfahren zum Herstellen dieses ImpfstoffesInfo
- Publication number
- DE2700338C2 DE2700338C2 DE2700338A DE2700338A DE2700338C2 DE 2700338 C2 DE2700338 C2 DE 2700338C2 DE 2700338 A DE2700338 A DE 2700338A DE 2700338 A DE2700338 A DE 2700338A DE 2700338 C2 DE2700338 C2 DE 2700338C2
- Authority
- DE
- Germany
- Prior art keywords
- vaccine
- pigs
- cells
- bronchiseptica
- bordetella bronchiseptica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005486 vaccine Drugs 0.000 title claims description 73
- 241000588779 Bordetella bronchiseptica Species 0.000 title claims description 40
- 241000282887 Suidae Species 0.000 title claims description 34
- 208000015181 infectious disease Diseases 0.000 title claims description 33
- 238000000034 method Methods 0.000 title description 8
- 238000002360 preparation method Methods 0.000 title description 6
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 239000002054 inoculum Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 1
- 229940031551 inactivated vaccine Drugs 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 32
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 16
- 210000001944 turbinate Anatomy 0.000 description 15
- 239000000654 additive Substances 0.000 description 14
- 230000000996 additive effect Effects 0.000 description 12
- 206010003694 Atrophy Diseases 0.000 description 9
- 230000037444 atrophy Effects 0.000 description 9
- 230000006378 damage Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 230000003053 immunization Effects 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 241000282898 Sus scrofa Species 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 238000002649 immunization Methods 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 238000002604 ultrasonography Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 5
- 229940024545 aluminum hydroxide Drugs 0.000 description 5
- 229960001212 bacterial vaccine Drugs 0.000 description 5
- 239000006161 blood agar Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 235000019483 Peanut oil Nutrition 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
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- 239000000312 peanut oil Substances 0.000 description 4
- 229940124530 sulfonamide Drugs 0.000 description 4
- 150000003456 sulfonamides Chemical class 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 241000588807 Bordetella Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
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- 235000013372 meat Nutrition 0.000 description 3
- 210000000537 nasal bone Anatomy 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 206010039083 rhinitis Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- YVQVOQKFMFRVGR-VGOFMYFVSA-N 5-(morpholin-4-ylmethyl)-3-[(e)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)OC(CN2CCOCC2)C1 YVQVOQKFMFRVGR-VGOFMYFVSA-N 0.000 description 2
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 206010039088 Rhinitis atrophic Diseases 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
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- 238000010438 heat treatment Methods 0.000 description 2
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- 230000002458 infectious effect Effects 0.000 description 2
- 230000036244 malformation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229960002135 sulfadimidine Drugs 0.000 description 2
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- JDRAOGVAQOVDEB-KTKRTIGZSA-N (3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl) (z)-octadec-9-enoate Chemical compound OC1COC2C(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC21 JDRAOGVAQOVDEB-KTKRTIGZSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- -1 B. 384 g Chemical compound 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000001987 Bordet-Gengou agar Substances 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 208000000655 Distemper Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010021432 Immunisation reaction Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 1
- IFXKRZPOFLOFJY-UHFFFAOYSA-N [Na].CC[Hg] Chemical compound [Na].CC[Hg] IFXKRZPOFLOFJY-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
- 229940022504 aluminum oxide paste Drugs 0.000 description 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229940093761 bile salts Drugs 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000014058 canine distemper Diseases 0.000 description 1
- 229940030156 cell vaccine Drugs 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 235000020243 first infant milk formula Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229950000337 furaltadone Drugs 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940124452 immunizing agent Drugs 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- FFJIWWBSBCOKLS-UHFFFAOYSA-N sulfaethoxypyridazine Chemical compound N1=NC(OCC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 FFJIWWBSBCOKLS-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229940068492 thiosalicylate Drugs 0.000 description 1
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2700338A DE2700338C2 (de) | 1977-01-05 | 1977-01-05 | Parenteral injizierbarer Impfstoff für Schweine gegen Infektionen von Bordetella bronchiseptica sowie Verfahren zum Herstellen dieses Impfstoffes |
| AU21066/77A AU516010B2 (en) | 1977-01-05 | 1977-01-05 | Bordetella bronchiseptica vaccine |
| BE173882A BE850141A (fr) | 1977-01-05 | 1977-01-06 | Vaccin |
| FR7700247A FR2376665A1 (fr) | 1977-01-05 | 1977-01-06 | Vaccin administrable aux animaux sujets a une infection par le bordetella bronchiseptica |
| GB892/77A GB1552611A (en) | 1977-01-05 | 1977-01-11 | Vaccine for immunization of swine against bordetella brochiseptica infection and method of use |
| NLAANVRAGE7700319,A NL179875C (nl) | 1977-01-05 | 1977-01-13 | Werkwijze ter bereiding van een vaccin tegen atrofische rhinitis bij varkens. |
| CH262077A CH601479A5 (en) | 1977-01-05 | 1977-03-02 | Injectable Bordetella bronchiseptica vaccine |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2700338A DE2700338C2 (de) | 1977-01-05 | 1977-01-05 | Parenteral injizierbarer Impfstoff für Schweine gegen Infektionen von Bordetella bronchiseptica sowie Verfahren zum Herstellen dieses Impfstoffes |
| AU21066/77A AU516010B2 (en) | 1977-01-05 | 1977-01-05 | Bordetella bronchiseptica vaccine |
| BE850141 | 1977-01-06 | ||
| BE173882A BE850141A (fr) | 1977-01-05 | 1977-01-06 | Vaccin |
| FR7700247A FR2376665A1 (fr) | 1977-01-05 | 1977-01-06 | Vaccin administrable aux animaux sujets a une infection par le bordetella bronchiseptica |
| GB892/77A GB1552611A (en) | 1977-01-05 | 1977-01-11 | Vaccine for immunization of swine against bordetella brochiseptica infection and method of use |
| NLAANVRAGE7700319,A NL179875C (nl) | 1977-01-05 | 1977-01-13 | Werkwijze ter bereiding van een vaccin tegen atrofische rhinitis bij varkens. |
| CH262077A CH601479A5 (en) | 1977-01-05 | 1977-03-02 | Injectable Bordetella bronchiseptica vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2700338A1 DE2700338A1 (de) | 1978-07-13 |
| DE2700338C2 true DE2700338C2 (de) | 1985-11-21 |
Family
ID=37732202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2700338A Expired DE2700338C2 (de) | 1977-01-05 | 1977-01-05 | Parenteral injizierbarer Impfstoff für Schweine gegen Infektionen von Bordetella bronchiseptica sowie Verfahren zum Herstellen dieses Impfstoffes |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU516010B2 (enrdf_load_stackoverflow) |
| BE (1) | BE850141A (enrdf_load_stackoverflow) |
| CH (1) | CH601479A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2700338C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2376665A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1552611A (enrdf_load_stackoverflow) |
| NL (1) | NL179875C (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203970A (en) * | 1979-03-05 | 1980-05-20 | Merck & Co., Inc. | Swine atropic rhinitis vaccine |
| AU575086B2 (en) * | 1983-11-07 | 1988-07-21 | Syntex (U.S.A.) Inc. | Bordetella bronchiseptica pili subunit protein and vaccine |
| IE59079B1 (en) * | 1986-11-05 | 1994-01-12 | Oldcastle Veterinary Research | A method of preparing an autogenous vaccine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5127731B1 (enrdf_load_stackoverflow) * | 1971-05-12 | 1976-08-14 |
-
1977
- 1977-01-05 AU AU21066/77A patent/AU516010B2/en not_active Expired
- 1977-01-05 DE DE2700338A patent/DE2700338C2/de not_active Expired
- 1977-01-06 BE BE173882A patent/BE850141A/xx not_active IP Right Cessation
- 1977-01-06 FR FR7700247A patent/FR2376665A1/fr active Granted
- 1977-01-11 GB GB892/77A patent/GB1552611A/en not_active Expired
- 1977-01-13 NL NLAANVRAGE7700319,A patent/NL179875C/xx not_active IP Right Cessation
- 1977-03-02 CH CH262077A patent/CH601479A5/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2376665A1 (fr) | 1978-08-04 |
| NL7700319A (en) | 1978-07-17 |
| FR2376665B1 (enrdf_load_stackoverflow) | 1979-04-20 |
| DE2700338A1 (de) | 1978-07-13 |
| GB1552611A (en) | 1979-09-19 |
| AU2106677A (en) | 1978-07-13 |
| NL179875C (nl) | 1986-12-01 |
| AU516010B2 (en) | 1981-05-14 |
| BE850141A (fr) | 1977-05-02 |
| CH601479A5 (en) | 1978-07-14 |
| NL179875B (nl) | 1986-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |