DE2656374A1 - Pyrazincarboxamide und verfahren zu ihrer herstellung - Google Patents

Pyrazincarboxamide und verfahren zu ihrer herstellung

Info

Publication number
DE2656374A1
DE2656374A1 DE19762656374 DE2656374A DE2656374A1 DE 2656374 A1 DE2656374 A1 DE 2656374A1 DE 19762656374 DE19762656374 DE 19762656374 DE 2656374 A DE2656374 A DE 2656374A DE 2656374 A1 DE2656374 A1 DE 2656374A1
Authority
DE
Germany
Prior art keywords
carbon atoms
hydrogen atom
radical
amino
alkyl radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19762656374
Other languages
German (de)
English (en)
Other versions
DE2656374C2 (enExample
Inventor
Jun Edward Jethro Cragoe
Charles Newcomer Habecker
Jun Otto William Woltersdorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2656374A1 publication Critical patent/DE2656374A1/de
Application granted granted Critical
Publication of DE2656374C2 publication Critical patent/DE2656374C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19762656374 1975-12-15 1976-12-13 Pyrazincarboxamide und verfahren zu ihrer herstellung Granted DE2656374A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64080375A 1975-12-15 1975-12-15

Publications (2)

Publication Number Publication Date
DE2656374A1 true DE2656374A1 (de) 1977-06-16
DE2656374C2 DE2656374C2 (enExample) 1989-08-10

Family

ID=24569755

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762656374 Granted DE2656374A1 (de) 1975-12-15 1976-12-13 Pyrazincarboxamide und verfahren zu ihrer herstellung

Country Status (14)

Country Link
US (1) US4085211A (enExample)
JP (1) JPS52106877A (enExample)
AU (1) AU511429B2 (enExample)
BE (1) BE849379A (enExample)
CH (1) CH630369A5 (enExample)
DE (1) DE2656374A1 (enExample)
DK (1) DK531476A (enExample)
ES (2) ES454160A1 (enExample)
FR (1) FR2335226A1 (enExample)
GB (1) GB1527297A (enExample)
HU (1) HU175504B (enExample)
NL (1) NL7613276A (enExample)
SE (1) SE431452B (enExample)
ZA (1) ZA767431B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
WO2006023617A3 (en) * 2004-08-18 2006-06-01 Michael R Johnson Cyclic amide & ester pyrazinoylguanidine sodium channel blockers
WO2007071400A1 (en) * 2005-12-22 2007-06-28 Novartis Ag Pyrazine derivatives as epithelial sodium channel blocker
DE102008053024A1 (de) 2008-10-24 2010-05-06 RUHR-UNIVERSITäT BOCHUM Mittel zur Bekämpfung von Insekten und Milben

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208413A (en) * 1977-03-04 1980-06-17 Merck & Co., Inc. N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
US4163781A (en) * 1978-04-17 1979-08-07 Merck & Co., Inc. 3-Amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamide compounds, compositions and methods of use
US4277602A (en) * 1980-07-02 1981-07-07 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-truazin-2-yl)2-pyrazinecarboxamides
US4272537A (en) * 1980-07-02 1981-06-09 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides
FI820266A7 (fi) * 1981-02-02 1982-08-03 Ici Plc Alkanoliaminijohdannaisia.
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
JPS62291361A (ja) * 1986-06-09 1987-12-18 株式会社ブリヂストン 床支持装置
JPS6342741U (enExample) * 1986-09-04 1988-03-22
GB8810934D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Amides
GB8810933D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8812342D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
GB8812343D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Amino compounds
JPH02101937U (enExample) * 1989-01-31 1990-08-14
AUPP646498A0 (en) * 1998-10-12 1998-11-05 Australian National University, The A method of modulating ion channel functional activity
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
ES2654395T3 (es) * 2007-12-10 2018-02-13 Novartis Ag Análogos de amilorida espirocíclicos como bloqueantes de ENaC
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
JP6607191B2 (ja) * 2014-09-18 2019-11-20 日産化学株式会社 液晶配向剤、液晶配向膜、及び液晶表示素子

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470053B (de) * Merck & Co Ine , Rahway, N J (VStA) 3,5 Diamino 6 chlor pyrazmoyl guanidine, deren Salze und Verfahren zu ihrer Herstellung
US3313813A (en) * 1962-10-30 1967-04-11 Merck & Co Inc (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299929A (enExample) * 1962-10-30

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470053B (de) * Merck & Co Ine , Rahway, N J (VStA) 3,5 Diamino 6 chlor pyrazmoyl guanidine, deren Salze und Verfahren zu ihrer Herstellung
US3313813A (en) * 1962-10-30 1967-04-11 Merck & Co Inc (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
WO2006023617A3 (en) * 2004-08-18 2006-06-01 Michael R Johnson Cyclic amide & ester pyrazinoylguanidine sodium channel blockers
US8143256B2 (en) 2004-08-18 2012-03-27 Parion Sciences, Inc. Cyclic amide and ester pyrazinoylguanidine sodium channel blockers
WO2007071400A1 (en) * 2005-12-22 2007-06-28 Novartis Ag Pyrazine derivatives as epithelial sodium channel blocker
DE102008053024A1 (de) 2008-10-24 2010-05-06 RUHR-UNIVERSITäT BOCHUM Mittel zur Bekämpfung von Insekten und Milben

Also Published As

Publication number Publication date
JPS6238350B2 (enExample) 1987-08-17
BE849379A (fr) 1977-06-14
GB1527297A (en) 1978-10-04
FR2335226A1 (fr) 1977-07-15
CH630369A5 (de) 1982-06-15
ES465742A1 (es) 1978-10-01
AU511429B2 (en) 1980-08-21
NL7613276A (nl) 1977-06-17
AU2018176A (en) 1978-06-08
ZA767431B (en) 1978-07-26
FR2335226B1 (enExample) 1979-03-09
SE7613289L (sv) 1977-06-16
ES454160A1 (es) 1978-03-01
HU175504B (hu) 1980-08-28
DK531476A (da) 1977-06-16
JPS52106877A (en) 1977-09-07
SE431452B (sv) 1984-02-06
DE2656374C2 (enExample) 1989-08-10
US4085211A (en) 1978-04-18

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: ABITZ, W., DIPL.-ING.DR.-ING. MORF, D., DR., PAT.-

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee