DE2635558A1 - Somatostatinanaloge - Google Patents
SomatostatinanalogeInfo
- Publication number
- DE2635558A1 DE2635558A1 DE19762635558 DE2635558A DE2635558A1 DE 2635558 A1 DE2635558 A1 DE 2635558A1 DE 19762635558 DE19762635558 DE 19762635558 DE 2635558 A DE2635558 A DE 2635558A DE 2635558 A1 DE2635558 A1 DE 2635558A1
- Authority
- DE
- Germany
- Prior art keywords
- phe
- thr
- lys
- inoc
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 1
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- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
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- GKZIWHRNKRBEOH-UHFFFAOYSA-N phenylalanylphenylalanine Chemical compound C=1C=CC=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 GKZIWHRNKRBEOH-UHFFFAOYSA-N 0.000 description 1
- 108010073025 phenylalanylphenylalanine Proteins 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
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- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
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- 125000003375 sulfoxide group Chemical group 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
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- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60306775A | 1975-08-08 | 1975-08-08 | |
| US68000576A | 1976-04-23 | 1976-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2635558A1 true DE2635558A1 (de) | 1977-02-17 |
Family
ID=27084324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762635558 Withdrawn DE2635558A1 (de) | 1975-08-08 | 1976-08-06 | Somatostatinanaloge |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5219659A (enrdf_load_stackoverflow) |
| CH (1) | CH626328A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2635558A1 (enrdf_load_stackoverflow) |
| DK (1) | DK328876A (enrdf_load_stackoverflow) |
| FR (1) | FR2320109A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1502573A (enrdf_load_stackoverflow) |
| NL (1) | NL7607987A (enrdf_load_stackoverflow) |
| SE (1) | SE419440B (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014230A1 (en) * | 1978-10-28 | 1980-08-20 | Shiraimatsu Shinyaku Company Ltd. | Undecapeptide and its acid addition salts and pharmaceutical compositions |
| EP0017760A1 (de) * | 1979-03-16 | 1980-10-29 | Ciba-Geigy Ag | Somatostatin-analoge Peptide, ihre Herstellung und Verwendung, sie enthaltende pharmazeutische Präparate und deren Herstellung |
| US4238481A (en) * | 1977-09-28 | 1980-12-09 | Ciba-Geigy Corporation | Novel cyclopeptides |
| US4244947A (en) * | 1979-08-13 | 1981-01-13 | Ayerst Mckenna And Harrison Inc. | Carba decapeptide derivatives of [TYR6 ]-somatostatin |
| DE3716437A1 (de) * | 1986-05-27 | 1987-12-03 | Sandoz Ag | Pharmazeutische zusammensetzung |
| RU2142450C1 (ru) * | 1993-08-20 | 1999-12-10 | Хафслунд Никомед Фарма АГ | Асимметрично замещенные производные диаминодикарбоновой кислоты и способ их получения |
| EP1231919A4 (en) * | 1999-09-08 | 2005-02-23 | Sloan Kettering Institutefor C | NOVEL CLASS OF CYTODIFFERENTIATION AGENTS AND HISTONE DEACETYLASE INHIBITORS, AND METHODS OF USING THE SAME |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115554A (en) * | 1977-08-29 | 1978-09-19 | Merck & Co., Inc. | Somatostatin analogs |
| US4139526A (en) * | 1977-12-01 | 1979-02-13 | Merck & Co., Inc. | Somatostatin analogs |
| US4140767A (en) * | 1977-12-01 | 1979-02-20 | Merck & Co., Inc. | Somatostatin analogs |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| ATE166359T1 (de) * | 1991-08-09 | 1998-06-15 | Winfried Kolbeck | Peptide mit einer lanthionin-brücke |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6509712A (enrdf_load_stackoverflow) * | 1964-07-27 | 1966-01-28 | ||
| DE2460469A1 (de) * | 1974-12-20 | 1976-07-01 | Hoechst Ag | Neue peptide mit biologischer wirkung und verfahren zu ihrer herstellung |
-
1976
- 1976-07-19 NL NL7607987A patent/NL7607987A/xx not_active Application Discontinuation
- 1976-07-21 DK DK328876A patent/DK328876A/da unknown
- 1976-07-21 SE SE7608300A patent/SE419440B/xx unknown
- 1976-08-03 GB GB32268/76A patent/GB1502573A/en not_active Expired
- 1976-08-05 CH CH1002176A patent/CH626328A5/de not_active IP Right Cessation
- 1976-08-05 FR FR7623935A patent/FR2320109A1/fr active Granted
- 1976-08-06 DE DE19762635558 patent/DE2635558A1/de not_active Withdrawn
- 1976-08-09 JP JP51094076A patent/JPS5219659A/ja active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4238481A (en) * | 1977-09-28 | 1980-12-09 | Ciba-Geigy Corporation | Novel cyclopeptides |
| EP0014230A1 (en) * | 1978-10-28 | 1980-08-20 | Shiraimatsu Shinyaku Company Ltd. | Undecapeptide and its acid addition salts and pharmaceutical compositions |
| EP0017760A1 (de) * | 1979-03-16 | 1980-10-29 | Ciba-Geigy Ag | Somatostatin-analoge Peptide, ihre Herstellung und Verwendung, sie enthaltende pharmazeutische Präparate und deren Herstellung |
| US4244947A (en) * | 1979-08-13 | 1981-01-13 | Ayerst Mckenna And Harrison Inc. | Carba decapeptide derivatives of [TYR6 ]-somatostatin |
| DE3716437A1 (de) * | 1986-05-27 | 1987-12-03 | Sandoz Ag | Pharmazeutische zusammensetzung |
| RU2142450C1 (ru) * | 1993-08-20 | 1999-12-10 | Хафслунд Никомед Фарма АГ | Асимметрично замещенные производные диаминодикарбоновой кислоты и способ их получения |
| EP1231919A4 (en) * | 1999-09-08 | 2005-02-23 | Sloan Kettering Institutefor C | NOVEL CLASS OF CYTODIFFERENTIATION AGENTS AND HISTONE DEACETYLASE INHIBITORS, AND METHODS OF USING THE SAME |
| US7126001B2 (en) | 1999-09-08 | 2006-10-24 | Sloan-Kettering Institute For Cancer Research | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
| US7345174B2 (en) | 1999-09-08 | 2008-03-18 | Sloan-Kettering Institute For Cancer Research | Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DK328876A (da) | 1977-02-09 |
| GB1502573A (en) | 1978-03-01 |
| CH626328A5 (en) | 1981-11-13 |
| SE7608300L (sv) | 1977-02-09 |
| FR2320109A1 (fr) | 1977-03-04 |
| SE419440B (sv) | 1981-08-03 |
| NL7607987A (nl) | 1977-02-10 |
| FR2320109B1 (enrdf_load_stackoverflow) | 1979-05-25 |
| JPS5219659A (en) | 1977-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |