CH626328A5 - Process for the preparation of somatostatin analogues - Google Patents
Process for the preparation of somatostatin analogues Download PDFInfo
- Publication number
- CH626328A5 CH626328A5 CH1002176A CH1002176A CH626328A5 CH 626328 A5 CH626328 A5 CH 626328A5 CH 1002176 A CH1002176 A CH 1002176A CH 1002176 A CH1002176 A CH 1002176A CH 626328 A5 CH626328 A5 CH 626328A5
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- Prior art keywords
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- thr
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title claims description 56
- 238000000034 method Methods 0.000 title claims description 40
- 238000002360 preparation method Methods 0.000 title claims description 26
- 230000008569 process Effects 0.000 title claims description 13
- 229940075620 somatostatin analogue Drugs 0.000 title description 2
- 239000000243 solution Substances 0.000 claims description 105
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- 229960000553 somatostatin Drugs 0.000 claims description 49
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 47
- 238000006243 chemical reaction Methods 0.000 claims description 39
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
- 102000005157 Somatostatin Human genes 0.000 claims description 24
- 108010056088 Somatostatin Proteins 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 24
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 22
- 229940024606 amino acid Drugs 0.000 claims description 19
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 18
- 238000004519 manufacturing process Methods 0.000 claims description 18
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- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
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- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical compound NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60306775A | 1975-08-08 | 1975-08-08 | |
| US68000576A | 1976-04-23 | 1976-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH626328A5 true CH626328A5 (en) | 1981-11-13 |
Family
ID=27084324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1002176A CH626328A5 (en) | 1975-08-08 | 1976-08-05 | Process for the preparation of somatostatin analogues |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5219659A (enrdf_load_stackoverflow) |
| CH (1) | CH626328A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2635558A1 (enrdf_load_stackoverflow) |
| DK (1) | DK328876A (enrdf_load_stackoverflow) |
| FR (1) | FR2320109A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1502573A (enrdf_load_stackoverflow) |
| NL (1) | NL7607987A (enrdf_load_stackoverflow) |
| SE (1) | SE419440B (enrdf_load_stackoverflow) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115554A (en) * | 1977-08-29 | 1978-09-19 | Merck & Co., Inc. | Somatostatin analogs |
| LU78191A1 (de) * | 1977-09-28 | 1979-05-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen cyclopeptiden |
| US4139526A (en) * | 1977-12-01 | 1979-02-13 | Merck & Co., Inc. | Somatostatin analogs |
| US4140767A (en) * | 1977-12-01 | 1979-02-20 | Merck & Co., Inc. | Somatostatin analogs |
| JPS5819669B2 (ja) * | 1978-10-28 | 1983-04-19 | 白井松新薬株式会社 | 新規生理活性ペプチド化合物及びその製造法 |
| US4316890A (en) * | 1979-03-16 | 1982-02-23 | Ciba-Geigy Corporation | Peptides and processes for the manufacture thereof |
| US4244947A (en) * | 1979-08-13 | 1981-01-13 | Ayerst Mckenna And Harrison Inc. | Carba decapeptide derivatives of [TYR6 ]-somatostatin |
| HU198626B (en) * | 1986-05-27 | 1989-11-28 | Sandoz Ag | Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| ATE166359T1 (de) * | 1991-08-09 | 1998-06-15 | Winfried Kolbeck | Peptide mit einer lanthionin-brücke |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| AT401517B (de) * | 1993-08-20 | 1996-09-25 | Hafslund Nycomed Pharma | Asymmetrisch substituierte diaminodicarbonsäurederivate und ein verfahren zu deren herstellung |
| EA007649B1 (ru) * | 1999-09-08 | 2006-12-29 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6509712A (enrdf_load_stackoverflow) * | 1964-07-27 | 1966-01-28 | ||
| DE2460469A1 (de) * | 1974-12-20 | 1976-07-01 | Hoechst Ag | Neue peptide mit biologischer wirkung und verfahren zu ihrer herstellung |
-
1976
- 1976-07-19 NL NL7607987A patent/NL7607987A/xx not_active Application Discontinuation
- 1976-07-21 DK DK328876A patent/DK328876A/da unknown
- 1976-07-21 SE SE7608300A patent/SE419440B/xx unknown
- 1976-08-03 GB GB32268/76A patent/GB1502573A/en not_active Expired
- 1976-08-05 CH CH1002176A patent/CH626328A5/de not_active IP Right Cessation
- 1976-08-05 FR FR7623935A patent/FR2320109A1/fr active Granted
- 1976-08-06 DE DE19762635558 patent/DE2635558A1/de not_active Withdrawn
- 1976-08-09 JP JP51094076A patent/JPS5219659A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK328876A (da) | 1977-02-09 |
| DE2635558A1 (de) | 1977-02-17 |
| GB1502573A (en) | 1978-03-01 |
| SE7608300L (sv) | 1977-02-09 |
| FR2320109A1 (fr) | 1977-03-04 |
| SE419440B (sv) | 1981-08-03 |
| NL7607987A (nl) | 1977-02-10 |
| FR2320109B1 (enrdf_load_stackoverflow) | 1979-05-25 |
| JPS5219659A (en) | 1977-02-15 |
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| Date | Code | Title | Description |
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| PL | Patent ceased | ||
| PL | Patent ceased |