DE2542414A1 - Verfahren zur reinigung des mischesters aethylenglycol-1- eckige klammer auf 2-(p-chlorphenoxy)-2- methylpropionat eckige klammer zu -2-nicotinat - Google Patents
Verfahren zur reinigung des mischesters aethylenglycol-1- eckige klammer auf 2-(p-chlorphenoxy)-2- methylpropionat eckige klammer zu -2-nicotinatInfo
- Publication number
- DE2542414A1 DE2542414A1 DE19752542414 DE2542414A DE2542414A1 DE 2542414 A1 DE2542414 A1 DE 2542414A1 DE 19752542414 DE19752542414 DE 19752542414 DE 2542414 A DE2542414 A DE 2542414A DE 2542414 A1 DE2542414 A1 DE 2542414A1
- Authority
- DE
- Germany
- Prior art keywords
- nicotinate
- square
- chlorophenoxy
- cleaning
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title claims description 14
- 238000000034 method Methods 0.000 title claims description 11
- 239000011664 nicotinic acid Substances 0.000 title claims description 7
- 238000004140 cleaning Methods 0.000 title claims description 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003208 petroleum Substances 0.000 claims description 4
- 239000005909 Kieselgur Substances 0.000 claims description 3
- SSFDAZXGUKDEAH-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)C1=CC=C(Cl)C=C1 SSFDAZXGUKDEAH-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 229940017219 methyl propionate Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- -1 p-chlorophenoxy Chemical group 0.000 claims 1
- 239000003921 oil Substances 0.000 description 4
- TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000000055 hyoplipidemic effect Effects 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- YLBFOPIKCVAFHC-UHFFFAOYSA-N [Si](O)(O)(O)O.[Si](Cl)(Cl)(Cl)Cl Chemical compound [Si](O)(O)(O)O.[Si](Cl)(Cl)(Cl)Cl YLBFOPIKCVAFHC-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES438245A ES438245A1 (es) | 1975-06-04 | 1975-06-04 | Procedimiento de purificacion del ester mixto 1-(2-(p-cloro-fenoxi)-2metilpropionato), 2-nicotinato de etilenglicol. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2542414A1 true DE2542414A1 (de) | 1976-12-09 |
Family
ID=8469444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752542414 Pending DE2542414A1 (de) | 1975-06-04 | 1975-09-23 | Verfahren zur reinigung des mischesters aethylenglycol-1- eckige klammer auf 2-(p-chlorphenoxy)-2- methylpropionat eckige klammer zu -2-nicotinat |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4028369A (enExample) |
| JP (1) | JPS51143670A (enExample) |
| DE (1) | DE2542414A1 (enExample) |
| ES (1) | ES438245A1 (enExample) |
| FR (1) | FR2313058A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES469531A1 (es) * | 1978-05-05 | 1978-12-01 | Alter Lab | Un procedimiento de preparacion de ciertos diesteres de eti-lenglicol. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1213162A (en) * | 1966-11-16 | 1970-11-18 | Astra Ab | Serum lipid lowering pyridine derivatives and their preparation |
-
1975
- 1975-06-04 ES ES438245A patent/ES438245A1/es not_active Expired
- 1975-08-04 US US05/601,865 patent/US4028369A/en not_active Expired - Lifetime
- 1975-08-09 JP JP50097108A patent/JPS51143670A/ja active Pending
- 1975-08-20 FR FR7525795A patent/FR2313058A1/fr active Granted
- 1975-09-23 DE DE19752542414 patent/DE2542414A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4028369A (en) | 1977-06-07 |
| FR2313058A1 (fr) | 1976-12-31 |
| ES438245A1 (es) | 1977-01-16 |
| JPS51143670A (en) | 1976-12-10 |
| FR2313058B1 (enExample) | 1979-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHW | Rejection |