DE2540780A1 - Verfahren zum herstellen von peptiden mit einer disulfidringstruktur - Google Patents

Verfahren zum herstellen von peptiden mit einer disulfidringstruktur

Info

Publication number
DE2540780A1
DE2540780A1 DE19752540780 DE2540780A DE2540780A1 DE 2540780 A1 DE2540780 A1 DE 2540780A1 DE 19752540780 DE19752540780 DE 19752540780 DE 2540780 A DE2540780 A DE 2540780A DE 2540780 A1 DE2540780 A1 DE 2540780A1
Authority
DE
Germany
Prior art keywords
boc
peptide
thr
amino acid
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19752540780
Other languages
German (de)
English (en)
Other versions
DE2540780C2 (US08080257-20111220-C00005.png
Inventor
John Lawrence Hughes
Robert Chung-Huan Liu
Jay Kenneth Seyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour Pharmaceutical Co
Original Assignee
Armour Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour Pharmaceutical Co filed Critical Armour Pharmaceutical Co
Publication of DE2540780A1 publication Critical patent/DE2540780A1/de
Application granted granted Critical
Publication of DE2540780C2 publication Critical patent/DE2540780C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/15—Oxytocin or vasopressin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19752540780 1974-09-12 1975-09-12 Verfahren zum herstellen von peptiden mit einer disulfidringstruktur Granted DE2540780A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US505344A US3929758A (en) 1974-09-12 1974-09-12 Cyclization of cysteine-containing peptides

Publications (2)

Publication Number Publication Date
DE2540780A1 true DE2540780A1 (de) 1976-04-01
DE2540780C2 DE2540780C2 (US08080257-20111220-C00005.png) 1989-05-24

Family

ID=24009941

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752540780 Granted DE2540780A1 (de) 1974-09-12 1975-09-12 Verfahren zum herstellen von peptiden mit einer disulfidringstruktur

Country Status (16)

Country Link
US (1) US3929758A (US08080257-20111220-C00005.png)
JP (1) JPS5833864B2 (US08080257-20111220-C00005.png)
AU (1) AU498757B2 (US08080257-20111220-C00005.png)
BE (1) BE833336A (US08080257-20111220-C00005.png)
CA (1) CA1045117A (US08080257-20111220-C00005.png)
DE (1) DE2540780A1 (US08080257-20111220-C00005.png)
DK (1) DK409775A (US08080257-20111220-C00005.png)
ES (1) ES440922A1 (US08080257-20111220-C00005.png)
FR (1) FR2284591A1 (US08080257-20111220-C00005.png)
GB (1) GB1527252A (US08080257-20111220-C00005.png)
HU (1) HU175202B (US08080257-20111220-C00005.png)
IT (1) IT1042496B (US08080257-20111220-C00005.png)
LU (1) LU73386A1 (US08080257-20111220-C00005.png)
NL (1) NL179909C (US08080257-20111220-C00005.png)
SU (1) SU849998A3 (US08080257-20111220-C00005.png)
YU (1) YU39747B (US08080257-20111220-C00005.png)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033940A (en) * 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4066634A (en) * 1976-08-31 1978-01-03 American Home Products Corporation Purification of synthetic somatostatin
US4304692A (en) * 1978-07-24 1981-12-08 Armour Pharmaceutical Company Synthesis of biologically active peptides
US4212795A (en) * 1978-11-13 1980-07-15 Armour Pharmaceutical Company Cyclization of peptides
US4397780A (en) * 1982-02-12 1983-08-09 Armour Pharmaceutical Company Leucine22 -calcitonin
US4391747A (en) * 1982-02-12 1983-07-05 Armour Pharmaceutical Company Des asparagine-3-calcitonin
US4401593A (en) * 1982-02-12 1983-08-30 Armour Pharmaceutical Company Glycine - 8 calcitonin
US4388235A (en) * 1982-02-12 1983-06-14 Armour Pharmaceutical Company Synthesis of peptides
US4469632A (en) * 1982-09-24 1984-09-04 Armour Pharmaceutical Company D-Arginine24 calcitonin
US4444681A (en) * 1982-09-24 1984-04-24 Armour Pharmaceutical Company L-Tyrosine21 calcitonin
US4451395A (en) * 1982-11-08 1984-05-29 Armour Pharmaceutical Company Des-serine2 -des-tyrosine22 calcitonin
JPS60500054A (ja) * 1983-02-15 1985-01-17 ア−マ−・フア−マシユ−テイカル・カンパニ− デス−アスパラギン−３−カルシトニン
JPS60500055A (ja) * 1983-02-15 1985-01-17 ア−マ−・ファ−マシュ−ティカル・カンパニ− グリシン−８−カルシトニン
US4549986A (en) * 1983-12-23 1985-10-29 The Salk Institute For Biological Studies Human CGRP
US4623716A (en) * 1984-11-01 1986-11-18 Usv Pharmaceutical Corp. Process for the preparation and purification of peptides
JPH0517511Y2 (US08080257-20111220-C00005.png) * 1985-09-30 1993-05-11
US4644054A (en) * 1985-10-01 1987-02-17 Kempe Tomas G Calcitonin analogs with amino acid substituents at position 31
US4658014A (en) * 1985-12-20 1987-04-14 Kempe Tomas G Synthetic peptides with calcitonin-like activity
US4697002A (en) * 1985-12-23 1987-09-29 Kempe Tomas G Calcitonin gene related peptide analogs with amino acid subdstituents at the penultimate position 36
US4687839A (en) * 1985-12-23 1987-08-18 Kempe Tomas G Calcitonin gene related peptide analogs with C-terminal D-amino acid substituents
US4820804A (en) * 1987-04-21 1989-04-11 Rorer Pharmaceutical Corporation Analogs of [1,7-di-alanine, des-19-leucine]calcitonin
US4824936A (en) * 1987-05-06 1989-04-25 Rorer Pharmaceutical Corporation (19-Alanine) calcitonin
JP2682061B2 (ja) * 1988-10-07 1997-11-26 藤沢薬品工業株式会社 ペプチドの分子内ジスルフィド結合の形成法
ES2051647B1 (es) * 1992-12-10 1995-01-16 Lipotec Sa Procedimiento para la preparacion de calcitonina de salmon.
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
KR100193104B1 (ko) * 1993-06-29 1999-06-15 훼링비.브이 비강 투여를 위한 데스모프레신 조성물
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
ATE193892T1 (de) * 1993-06-29 2000-06-15 Ferring Bv Synthese zyklischer peptide
SE9400918L (sv) * 1994-03-18 1995-09-19 Anne Fjellstad Paulsen Stabiliserad komposition för oral administrering av peptider
US5763398A (en) * 1996-06-20 1998-06-09 Ferring B.V. Nasal administration of desmopressin
US5922680A (en) * 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
WO2008077621A1 (de) * 2006-12-23 2008-07-03 Aplagen Gmbh Verfahren zur ausbildung von disulfidbrücken
JP2014517832A (ja) 2011-05-10 2014-07-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 自己免疫疾患を治療するための方法及び医薬組成物
GB201313352D0 (en) 2013-07-26 2013-09-11 Isis Innovation Identification of peptide ligands
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
WO2016184784A1 (en) 2015-05-15 2016-11-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Peptides including binding domain of plasmodium falciparum proteins (cbp1 and cbp2) to chemokine cx3cl1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2231775A1 (de) * 1971-07-07 1973-01-18 Ciba Geigy Ag Verfahren zur herstellung von cystinhaltigen peptiden

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560521A (en) * 1967-08-07 1971-02-02 Merck & Co Inc Blocking groups for cysteine containing peptides
US3679655A (en) * 1968-06-28 1972-07-25 Hoechst Ag N,n-disubstituted aminoethylcarbamyl protecting groups for cysteine
US3849388A (en) * 1968-10-15 1974-11-19 Ciba Geigy Corp Analogues of human thyrocalcitonin
DE1950711A1 (de) * 1968-10-15 1970-04-30 Ciba Geigy Neue Peptide und Verfahren zu ihrer Herstellung
GB1294771A (en) * 1969-01-31 1972-11-01 Sandoz Ltd Thyrocalcitonin derivative
CH523868A (de) * 1969-10-22 1972-06-15 Ciba Geigy Ag Verfahren zur Herstellung neuer Dotriacontapeptidamide und ihrer Derivate
US3801561A (en) * 1970-10-29 1974-04-02 Sandoz Ltd Derivatives of salmon thyrocalcitonin
ZA723287B (en) * 1971-06-18 1973-02-28 Hoffmann La Roche Nonapeptides and processes for the preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2231775A1 (de) * 1971-07-07 1973-01-18 Ciba Geigy Ag Verfahren zur herstellung von cystinhaltigen peptiden

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
Aminosäuren, Peptide, Proteine, Akademie-Verlag Berlin, 2. Aufl., 1973, S.93-94 *
Bull. Chem. Soc. Japan 40, 1967, 2913-18 *
Bull. Chem. soc. Japan 41, 1968, 182-186 *
Helv. Acta 52, 1969, 1789-95 *
HOPPE-SEYLER'S, Z. Physiol. Chem. 350, 1969, 1421-24 *
HOPPE-SEYLER'S, Z. Physiol. Chem. 351, 1970, 1384-88 *
HOPPE-SEYLER'S, Z. Physiol. Chem. 352, 1971, 419-429 *
HOPPE-SEYLER'S, Z. Physiol. Chem. 352, 1971, S.3 *
HOPPE-SEYLER'S, Z. Physiol. Chem. 354, 365-70 *
HOUBEN-WEYL: Methoden der organischen Chemie, Bd. XV/1, 1974, S.796 *
JAKUBKE, H.-D., JESCHKEIT, H. *
JAKUBKE, H.-D., JESCHKEIT, H.; Aminosäuren, Peptide, Proteine, Akademie-Verlag Berlin, 2. Aufl., 1973, S.93-94

Also Published As

Publication number Publication date
CA1045117A (en) 1978-12-26
AU8473775A (en) 1977-03-17
FR2284591A1 (fr) 1976-04-09
YU230075A (en) 1982-02-28
SU849998A3 (ru) 1981-07-23
LU73386A1 (US08080257-20111220-C00005.png) 1976-04-13
DE2540780C2 (US08080257-20111220-C00005.png) 1989-05-24
NL179909C (nl) 1986-12-01
HU175202B (hu) 1980-06-28
AU498757B2 (en) 1979-03-22
FR2284591B1 (US08080257-20111220-C00005.png) 1978-12-01
IT1042496B (it) 1980-01-30
YU39747B (en) 1985-04-30
JPS5156448A (US08080257-20111220-C00005.png) 1976-05-18
GB1527252A (en) 1978-10-04
ES440922A1 (es) 1977-06-16
JPS5833864B2 (ja) 1983-07-22
BE833336A (fr) 1975-12-31
DK409775A (da) 1976-03-13
US3929758A (en) 1975-12-30
NL7510761A (nl) 1976-03-16

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee