DE2460990A1 - Neue prostaglandin-analoga und verfahren zu ihrer herstellung - Google Patents
Neue prostaglandin-analoga und verfahren zu ihrer herstellungInfo
- Publication number
- DE2460990A1 DE2460990A1 DE19742460990 DE2460990A DE2460990A1 DE 2460990 A1 DE2460990 A1 DE 2460990A1 DE 19742460990 DE19742460990 DE 19742460990 DE 2460990 A DE2460990 A DE 2460990A DE 2460990 A1 DE2460990 A1 DE 2460990A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compound
- compounds
- carbon atoms
- hoe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000000543 intermediate Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- LFOSUYOLLOGQNI-UHFFFAOYSA-N methyl 2-[4-(4-chlorophenoxy)phenoxy]-2-methylpropanoate Chemical compound COC(=O)C(C)(C)OC1=CC=C(OC2=CC=C(Cl)C=C2)C=C1 LFOSUYOLLOGQNI-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 150000002780 morpholines Chemical class 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 description 1
- 150000003008 phosphonic acid esters Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical class C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742460990 DE2460990A1 (de) | 1974-12-21 | 1974-12-21 | Neue prostaglandin-analoga und verfahren zu ihrer herstellung |
| NL7514654A NL7514654A (nl) | 1974-12-21 | 1975-12-16 | Werkwijze voor het bereiden van nieuwe prosta- glandine-analoga. |
| ES443524A ES443524A1 (es) | 1974-12-21 | 1975-12-16 | Procedimiento para la preparacion de compuestos analogos de acidos prostanoicos que no existen en la naturaleza. |
| SE7514447A SE7514447L (sv) | 1974-12-21 | 1975-12-19 | Nya prostaglandin-analoger och forfaranden for deras framstellning |
| LU74076A LU74076A1 (enExample) | 1974-12-21 | 1975-12-19 | |
| FR7539194A FR2294696A1 (fr) | 1974-12-21 | 1975-12-19 | Nouveaux analogues de prostaglandines, leur procede de preparation et leurs applications |
| AU87727/75A AU8772775A (en) | 1974-12-21 | 1975-12-19 | Prostaglandin analogous compounds |
| ZA757872A ZA757872B (en) | 1974-12-21 | 1975-12-19 | Novel prostaglandin analogous compounds and process for preparing them |
| JP50150665A JPS5186449A (enExample) | 1974-12-21 | 1975-12-19 | |
| DK581075A DK581075A (da) | 1974-12-21 | 1975-12-19 | Prostaglandinanaloge samt deres fremstilling og anvendelse |
| BE163013A BE836950A (fr) | 1974-12-21 | 1975-12-22 | Nouveaux analogues de prostaglandines, leur procede de preparation et leurs applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742460990 DE2460990A1 (de) | 1974-12-21 | 1974-12-21 | Neue prostaglandin-analoga und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2460990A1 true DE2460990A1 (de) | 1976-07-01 |
Family
ID=5934352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742460990 Pending DE2460990A1 (de) | 1974-12-21 | 1974-12-21 | Neue prostaglandin-analoga und verfahren zu ihrer herstellung |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5186449A (enExample) |
| AU (1) | AU8772775A (enExample) |
| BE (1) | BE836950A (enExample) |
| DE (1) | DE2460990A1 (enExample) |
| DK (1) | DK581075A (enExample) |
| ES (1) | ES443524A1 (enExample) |
| FR (1) | FR2294696A1 (enExample) |
| LU (1) | LU74076A1 (enExample) |
| NL (1) | NL7514654A (enExample) |
| SE (1) | SE7514447L (enExample) |
| ZA (1) | ZA757872B (enExample) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4212985A (en) * | 1978-04-28 | 1980-07-15 | The Upjohn Company | cis-4,5-Didehydro-16-phenoxy-PGE1 compounds |
| WO1999012898A1 (en) * | 1997-09-09 | 1999-03-18 | The Procter & Gamble Company | Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists |
| US5977173A (en) * | 1997-09-09 | 1999-11-02 | Wos; John August | Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists |
| US6107338A (en) * | 1997-09-09 | 2000-08-22 | The Procter & Gamble Company | Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists |
| US6410780B1 (en) | 1998-03-31 | 2002-06-25 | The Procter & Gamble Co. | C11 oxymyl and hydroxylamino prostaglandins useful as medicaments |
| US6444840B1 (en) | 1998-03-31 | 2002-09-03 | The Procter & Gamble Co. | C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7388029B2 (en) | 2000-03-31 | 2008-06-17 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US7407987B2 (en) | 2000-03-31 | 2008-08-05 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| WO2011014649A1 (en) | 2009-07-29 | 2011-02-03 | Duke University | Compositions and methods for inhibiting hair growth |
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
-
1974
- 1974-12-21 DE DE19742460990 patent/DE2460990A1/de active Pending
-
1975
- 1975-12-16 ES ES443524A patent/ES443524A1/es not_active Expired
- 1975-12-16 NL NL7514654A patent/NL7514654A/xx unknown
- 1975-12-19 FR FR7539194A patent/FR2294696A1/fr active Granted
- 1975-12-19 SE SE7514447A patent/SE7514447L/xx unknown
- 1975-12-19 JP JP50150665A patent/JPS5186449A/ja active Pending
- 1975-12-19 DK DK581075A patent/DK581075A/da unknown
- 1975-12-19 ZA ZA757872A patent/ZA757872B/xx unknown
- 1975-12-19 AU AU87727/75A patent/AU8772775A/en not_active Expired
- 1975-12-19 LU LU74076A patent/LU74076A1/xx unknown
- 1975-12-22 BE BE163013A patent/BE836950A/xx unknown
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4212985A (en) * | 1978-04-28 | 1980-07-15 | The Upjohn Company | cis-4,5-Didehydro-16-phenoxy-PGE1 compounds |
| WO1999012898A1 (en) * | 1997-09-09 | 1999-03-18 | The Procter & Gamble Company | Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists |
| US5977173A (en) * | 1997-09-09 | 1999-11-02 | Wos; John August | Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists |
| US6048895A (en) * | 1997-09-09 | 2000-04-11 | The Procter & Gamble Company | Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists |
| US6107338A (en) * | 1997-09-09 | 2000-08-22 | The Procter & Gamble Company | Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists |
| US6410780B1 (en) | 1998-03-31 | 2002-06-25 | The Procter & Gamble Co. | C11 oxymyl and hydroxylamino prostaglandins useful as medicaments |
| US6444840B1 (en) | 1998-03-31 | 2002-09-03 | The Procter & Gamble Co. | C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists |
| USRE43372E1 (en) | 1999-03-05 | 2012-05-08 | Duke University | C16 unsaturated FP-selective prostaglandins analogs |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7074942B2 (en) | 1999-08-04 | 2006-07-11 | The Procter & Gamble Company | 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US7115659B2 (en) | 1999-08-04 | 2006-10-03 | The Procter & Gamble Company | Method of treating a condition by administering a prostaglandin derivative |
| US8906962B2 (en) | 2000-03-31 | 2014-12-09 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US7407987B2 (en) | 2000-03-31 | 2008-08-05 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8541466B2 (en) | 2000-03-31 | 2013-09-24 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8618086B2 (en) | 2000-03-31 | 2013-12-31 | Duke University | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US7388029B2 (en) | 2000-03-31 | 2008-06-17 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9346837B2 (en) | 2000-03-31 | 2016-05-24 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US9579270B2 (en) | 2000-03-31 | 2017-02-28 | Duke University | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US9675539B2 (en) | 2000-03-31 | 2017-06-13 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| WO2011014649A1 (en) | 2009-07-29 | 2011-02-03 | Duke University | Compositions and methods for inhibiting hair growth |
| US10159634B2 (en) | 2009-07-29 | 2018-12-25 | Elise A. Olsen | Compositions and methods for inhibiting hair growth |
| EP3871671A2 (en) | 2009-07-29 | 2021-09-01 | Olsen, Elise | Fp receptor antagonists for inhibiting hair growth |
Also Published As
| Publication number | Publication date |
|---|---|
| ES443524A1 (es) | 1977-05-01 |
| DK581075A (da) | 1976-06-22 |
| SE7514447L (sv) | 1976-06-22 |
| JPS5186449A (enExample) | 1976-07-29 |
| BE836950A (fr) | 1976-06-22 |
| NL7514654A (nl) | 1976-06-23 |
| LU74076A1 (enExample) | 1976-11-11 |
| ZA757872B (en) | 1976-11-24 |
| AU8772775A (en) | 1977-06-23 |
| FR2294696A1 (fr) | 1976-07-16 |
| FR2294696B1 (enExample) | 1978-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |