DE2448393A1 - 2-substituierte und 2,2-disubstituierte eckige klammer auf 1,3-dihydroxyindanyloxy- (oder -thio) eckige klammer zu -alkancarbonsaeuren und verfahren zur herstellung derselben - Google Patents

2-substituierte und 2,2-disubstituierte eckige klammer auf 1,3-dihydroxyindanyloxy- (oder -thio) eckige klammer zu -alkancarbonsaeuren und verfahren zur herstellung derselben

Info

Publication number
DE2448393A1
DE2448393A1 DE19742448393 DE2448393A DE2448393A1 DE 2448393 A1 DE2448393 A1 DE 2448393A1 DE 19742448393 DE19742448393 DE 19742448393 DE 2448393 A DE2448393 A DE 2448393A DE 2448393 A1 DE2448393 A1 DE 2448393A1
Authority
DE
Germany
Prior art keywords
carbon atoms
methyl
lower alkyl
phenyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19742448393
Other languages
German (de)
English (en)
Inventor
Jun Edward Jethro Cragoe
Jun Otto William Woltersdorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2448393A1 publication Critical patent/DE2448393A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19742448393 1973-10-12 1974-10-10 2-substituierte und 2,2-disubstituierte eckige klammer auf 1,3-dihydroxyindanyloxy- (oder -thio) eckige klammer zu -alkancarbonsaeuren und verfahren zur herstellung derselben Pending DE2448393A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40596473A 1973-10-12 1973-10-12
US05/492,943 US4006180A (en) 1973-10-12 1974-07-31 [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids

Publications (1)

Publication Number Publication Date
DE2448393A1 true DE2448393A1 (de) 1975-04-17

Family

ID=27019306

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742448393 Pending DE2448393A1 (de) 1973-10-12 1974-10-10 2-substituierte und 2,2-disubstituierte eckige klammer auf 1,3-dihydroxyindanyloxy- (oder -thio) eckige klammer zu -alkancarbonsaeuren und verfahren zur herstellung derselben

Country Status (8)

Country Link
US (1) US4006180A (instruction)
JP (1) JPS5077355A (instruction)
DE (1) DE2448393A1 (instruction)
DK (1) DK506774A (instruction)
FR (1) FR2247217B1 (instruction)
GB (1) GB1480239A (instruction)
NL (1) NL7412830A (instruction)
SE (1) SE7412047L (instruction)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093258A3 (en) * 2002-05-03 2004-08-19 Max Planck Gesellschaft Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases

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Publication number Priority date Publication date Assignee Title
US5001255A (en) * 1984-12-04 1991-03-19 Sandoz Pharm. Corp. Idene analogs of mevalonolactone and derivatives thereof
CN101029080A (zh) * 2001-11-21 2007-09-05 伯纳姆研究院 用于对iap抑制卡斯蛋白酶进行去阻遏的方法及组合物
US20050119176A1 (en) * 2001-11-21 2005-06-02 The Burnham Institute Methods and compositions for derepression of IAP-inhibited caspase
US20060258581A1 (en) * 2001-11-21 2006-11-16 Reed John C Methods and composition for derepressions of IAP-inhibited caspase
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
WO2006102068A2 (en) * 2005-03-17 2006-09-28 The Burnham Institute Methods and compositions for derepression of iap-inhibited caspase
US20070003535A1 (en) * 2005-03-17 2007-01-04 Reed John C Methods and compositions for derepression of IAP-inhibited caspase
US20110183358A1 (en) * 2005-03-17 2011-07-28 The Burnham Institute Methods and compositions for derepression of iap-inhibited caspase
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
US20090043099A1 (en) * 2006-03-17 2009-02-12 The Burnham Institute Methods and compositions for derepression of IAP-inhibited caspase
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
AU2013363218B2 (en) 2012-12-17 2018-03-15 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1498459A (instruction) * 1965-07-30 1968-01-08
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids
US3704314A (en) * 1968-11-25 1972-11-28 Merck & Co Inc (1-oxo-2-alkylideneindanyloxy) and (1-oxo - 2 - alkylideneindanylthio) alkanoic acids
US3776944A (en) * 1971-09-16 1973-12-04 Warner Lambert Co Tetraloneoxy acetic acids and esters thereof
US3906032A (en) * 1972-11-10 1975-09-16 Squibb & Sons Inc Dihydroxy-tetrahydronaphthyoxyisobutyric acids and alkyl esters and salts thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093258A3 (en) * 2002-05-03 2004-08-19 Max Planck Gesellschaft Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolyl-cis/trans-isomerases

Also Published As

Publication number Publication date
FR2247217B1 (instruction) 1978-02-03
US4006180A (en) 1977-02-01
JPS5077355A (instruction) 1975-06-24
GB1480239A (en) 1977-07-20
DK506774A (instruction) 1975-06-09
NL7412830A (nl) 1975-04-15
FR2247217A1 (instruction) 1975-05-09
SE7412047L (instruction) 1975-04-14

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