DE2443560C2 - - Google Patents
Info
- Publication number
- DE2443560C2 DE2443560C2 DE2443560A DE2443560A DE2443560C2 DE 2443560 C2 DE2443560 C2 DE 2443560C2 DE 2443560 A DE2443560 A DE 2443560A DE 2443560 A DE2443560 A DE 2443560A DE 2443560 C2 DE2443560 C2 DE 2443560C2
- Authority
- DE
- Germany
- Prior art keywords
- fraction
- cellulose
- sephadex
- solution
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 claims description 15
- 229920005654 Sephadex Polymers 0.000 claims description 14
- 239000012507 Sephadex™ Substances 0.000 claims description 14
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- 238000010828 elution Methods 0.000 claims description 11
- 239000012535 impurity Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 230000003115 biocidal effect Effects 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 6
- 241000186991 Streptomyces carzinostaticus Species 0.000 claims description 6
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 6
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- 238000000926 separation method Methods 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 4
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 claims description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 2
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- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 claims description 2
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- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims description 2
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
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- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
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Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10248673A JPS5413516B2 (enrdf_load_stackoverflow) | 1973-09-11 | 1973-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2443560A1 DE2443560A1 (de) | 1975-08-07 |
| DE2443560C2 true DE2443560C2 (enrdf_load_stackoverflow) | 1987-08-20 |
Family
ID=14328758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2443560A Granted DE2443560A1 (de) | 1973-09-11 | 1974-09-11 | Antibiotikum und verfahren zur herstellung desselben |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5413516B2 (enrdf_load_stackoverflow) |
| BE (1) | BE819520A (enrdf_load_stackoverflow) |
| CH (1) | CH592734A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2443560A1 (enrdf_load_stackoverflow) |
| DK (1) | DK138511B (enrdf_load_stackoverflow) |
| FR (1) | FR2242990B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1471909A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5424801A (en) * | 1977-07-28 | 1979-02-24 | Karupisu Shiyokuhin Kougiyou K | Novel antibiotics cc3603 and process for preparing same |
| DE2938993A1 (de) | 1979-09-26 | 1981-04-16 | Günther Dr. 7407 Rottenburg Winkelmann | Herbicolin, verfahren zu seiner herstellung und es enthaltende mittel |
| JPS6030679B2 (ja) * | 1979-10-09 | 1985-07-17 | 株式会社科薬 | 新制癌性抗生物質ｎｃｓ−ｃ |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1593504A (enrdf_load_stackoverflow) * | 1968-05-03 | 1970-06-01 | ||
| US3644617A (en) * | 1968-05-09 | 1972-02-22 | Pfizer | Mitomalcin and method for its production |
| JPS5243917B1 (enrdf_load_stackoverflow) * | 1971-02-13 | 1977-11-02 |
-
1973
- 1973-09-11 JP JP10248673A patent/JPS5413516B2/ja not_active Expired
-
1974
- 1974-08-21 GB GB3679274A patent/GB1471909A/en not_active Expired
- 1974-09-04 BE BE148185A patent/BE819520A/xx not_active IP Right Cessation
- 1974-09-09 FR FR7430451A patent/FR2242990B1/fr not_active Expired
- 1974-09-10 CH CH1230574A patent/CH592734A5/xx not_active IP Right Cessation
- 1974-09-10 DK DK477174AA patent/DK138511B/da not_active IP Right Cessation
- 1974-09-11 DE DE2443560A patent/DE2443560A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2242990A1 (enrdf_load_stackoverflow) | 1975-04-04 |
| GB1471909A (en) | 1977-04-27 |
| DK138511C (enrdf_load_stackoverflow) | 1979-02-19 |
| DK477174A (enrdf_load_stackoverflow) | 1975-05-12 |
| BE819520A (fr) | 1974-12-31 |
| FR2242990B1 (enrdf_load_stackoverflow) | 1978-11-10 |
| DK138511B (da) | 1978-09-18 |
| JPS5413516B2 (enrdf_load_stackoverflow) | 1979-05-31 |
| CH592734A5 (enrdf_load_stackoverflow) | 1977-11-15 |
| DE2443560A1 (de) | 1975-08-07 |
| JPS5052289A (enrdf_load_stackoverflow) | 1975-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |