DE2345422C2 - Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung - Google Patents

Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung

Info

Publication number
DE2345422C2
DE2345422C2 DE2345422A DE2345422A DE2345422C2 DE 2345422 C2 DE2345422 C2 DE 2345422C2 DE 2345422 A DE2345422 A DE 2345422A DE 2345422 A DE2345422 A DE 2345422A DE 2345422 C2 DE2345422 C2 DE 2345422C2
Authority
DE
Germany
Prior art keywords
dimethyl
dioxo
acid
piperazin
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2345422A
Other languages
German (de)
English (en)
Other versions
DE2345422A1 (de
Inventor
Volkard Dr. 7950 Biberach Austel
Wolfgang Dipl.-Chem. Dr. 7951 Mettenberg Eberlein
Joachim Dipl.-Chem. Dr. 7951 Warthausen Heider
Eberhard Dipl.-Chem. Dr. Kutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE2345422A priority Critical patent/DE2345422C2/de
Priority to AT651474A priority patent/AT330777B/de
Priority to FI742465A priority patent/FI52219C/fi
Priority to ES429473A priority patent/ES429473A1/es
Priority to IE1838/74A priority patent/IE40742B1/xx
Priority to SU2057995A priority patent/SU528035A3/ru
Priority to BG27624A priority patent/BG22390A3/xx
Priority to US05/503,072 priority patent/US3948898A/en
Priority to BG7428726A priority patent/BG26195A4/xx
Priority to AU73023/74A priority patent/AU489660B2/en
Priority to YU2391/74A priority patent/YU39928B/xx
Priority to MX559474U priority patent/MX4054E/es
Priority to BE148302A priority patent/BE819651A/xx
Priority to HUTO980A priority patent/HU167869B/hu
Priority to PH16248A priority patent/PH12918A/en
Priority to CA208,607A priority patent/CA1025869A/en
Priority to RO7400079932A priority patent/RO63655A/ro
Priority to DD180966A priority patent/DD115122A5/xx
Priority to ZA00745688A priority patent/ZA745688B/xx
Priority to CS7400006150A priority patent/CS185660B2/cs
Priority to CH1601477A priority patent/CH605779A5/xx
Priority to NLAANVRAGE7411843,A priority patent/NL176363C/xx
Priority to NO743220A priority patent/NO140978C/no
Priority to FR7430387A priority patent/FR2242979B1/fr
Priority to JP49102862A priority patent/JPS596868B2/ja
Priority to CH1218974A priority patent/CH605778A5/xx
Priority to SE7411312A priority patent/SE424863B/xx
Priority to GB3908374A priority patent/GB1446791A/en
Priority to DK472774A priority patent/DK137124C/da
Priority to IL45609A priority patent/IL45609A/en
Priority to PL1974190437A priority patent/PL96297B1/pl
Priority to PL1974173958A priority patent/PL91712B1/pl
Priority to PL1974190438A priority patent/PL96298B1/pl
Priority to ES433958A priority patent/ES433958A1/es
Priority to ES433959A priority patent/ES433959A1/es
Publication of DE2345422A1 publication Critical patent/DE2345422A1/de
Priority to SU2145942A priority patent/SU538664A3/ru
Priority to SU2145935A priority patent/SU545256A3/ru
Priority to AT560775A priority patent/AT334375B/de
Priority to AT560675A priority patent/AT334374B/de
Priority to US05/651,568 priority patent/US4021558A/en
Priority to HK41/80A priority patent/HK4180A/xx
Priority to MY330/81A priority patent/MY8100330A/xx
Application granted granted Critical
Publication of DE2345422C2 publication Critical patent/DE2345422C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2345422A 1973-09-08 1973-09-08 Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung Expired DE2345422C2 (de)

Priority Applications (42)

Application Number Priority Date Filing Date Title
DE2345422A DE2345422C2 (de) 1973-09-08 1973-09-08 Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung
AT651474A AT330777B (de) 1973-09-08 1974-08-08 Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
FI742465A FI52219C (fi) 1973-09-08 1974-08-21 Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia .
ES429473A ES429473A1 (es) 1973-09-08 1974-08-23 Procedimiento para la preparacion de nuevos derivados de isoquinoleina.
IE1838/74A IE40742B1 (en) 1973-09-08 1974-09-04 1,3-diketo-1,2,3,4-tetrahydroisoquinolines
SU2057995A SU528035A3 (ru) 1973-09-08 1974-09-04 Способ получени производных изохинолина или их солей
BG27624A BG22390A3 (pl) 1973-09-08 1974-09-04
US05/503,072 US3948898A (en) 1973-09-08 1974-09-04 1,3-Dioxo-2-aminoalkyl-4,4-dimethyl-isoquinolines and salts thereof
BG7428726A BG26195A4 (pl) 1973-09-08 1974-09-04
YU2391/74A YU39928B (en) 1973-09-08 1974-09-05 Process for preparing new isoquinoline derivatives
AU73023/74A AU489660B2 (en) 1974-09-05 N-SUBSTITUTED-l, 3-DIOXO-ISOQUINOLINES
DK472774A DK137124C (da) 1973-09-08 1974-09-06 R analogifremgangsmaade til fremstilling af isoquinolinderivate
HUTO980A HU167869B (pl) 1973-09-08 1974-09-06
PH16248A PH12918A (en) 1973-09-08 1974-09-06 1,3-dioxo-2-aminoalkyl-4,4-dimethyl-isoquinolines and salts thereof
CA208,607A CA1025869A (en) 1973-09-08 1974-09-06 Isoquinoline derivatives
RO7400079932A RO63655A (fr) 1973-09-08 1974-09-06 Procede pour la preparation des derives d'isoquinoline
DD180966A DD115122A5 (pl) 1973-09-08 1974-09-06
ZA00745688A ZA745688B (en) 1973-09-08 1974-09-06 Improvements relating to isoquinoline derivatives
CS7400006150A CS185660B2 (en) 1973-09-08 1974-09-06 Process for preparing new 2-substituted 4,4-dimethyl-1,3-dioxo/2h,4h/isochinolines
CH1601477A CH605779A5 (pl) 1973-09-08 1974-09-06
MX559474U MX4054E (es) 1973-09-08 1974-09-06 Procedimiento para la preparacion de derivados de isoquinoleina
NO743220A NO140978C (no) 1973-09-08 1974-09-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater
FR7430387A FR2242979B1 (pl) 1973-09-08 1974-09-06
JP49102862A JPS596868B2 (ja) 1973-09-08 1974-09-06 新規イソキノリン誘導体の製造方法
CH1218974A CH605778A5 (pl) 1973-09-08 1974-09-06
SE7411312A SE424863B (sv) 1973-09-08 1974-09-06 Analogiforfarande for framstellning av nya isokinolinderivat
GB3908374A GB1446791A (en) 1973-09-08 1974-09-06 1,3-diketo-1,2,3,4-tetrahydroisoquinolines
BE148302A BE819651A (fr) 1973-09-08 1974-09-06 Nouveaux derives d'isoquinoleine
IL45609A IL45609A (en) 1973-09-08 1974-09-06 Substituted isoquinoline 1,3-dione derivatives their preparation and pharmaceutical compositions containing them
NLAANVRAGE7411843,A NL176363C (nl) 1973-09-08 1974-09-06 Werkwijze voor het bereiden, c.q. vervaardigen van een farmaceutisch preparaat met bloeddrukverlagende werking en werkwijze voor het bereiden van daarin als werkzame stof te gebruiken 1-(4,4-dimethyl-1,3-dioxo-(2h,4h)-isochinolin-2-yl)-2- of -3-(4-gesubstitueerd piperazin-1-yl)ethaan- of -propaanderivaten.
PL1974190437A PL96297B1 (pl) 1973-09-08 1974-09-07 Sposob wytwarzania nowych pochodnych izochinoliny
PL1974173958A PL91712B1 (pl) 1973-09-08 1974-09-07
PL1974190438A PL96298B1 (pl) 1973-09-08 1974-09-07 Sposob wytwarzania nowych pochodnych izochinoliny
ES433958A ES433958A1 (es) 1973-09-08 1975-01-20 Procedimiento para la preparacion de nuevos derivados de isoquinoleina.
ES433959A ES433959A1 (es) 1973-09-08 1975-01-20 Procedimiento para la preparacion de nuevos derivados de isoquinoleina.
SU2145942A SU538664A3 (ru) 1973-09-08 1975-06-20 Способ получени производных изохинолина или их солей
SU2145935A SU545256A3 (ru) 1973-09-08 1975-06-20 Способ получени производных изохинолина или их солей
AT560775A AT334375B (de) 1973-09-08 1975-07-21 Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
AT560675A AT334374B (de) 1973-09-08 1975-07-21 Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
US05/651,568 US4021558A (en) 1973-09-08 1976-01-22 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
HK41/80A HK4180A (en) 1973-09-08 1980-01-31 1,3-diketo-1,2,3,4-tetrahydroisoquinolines
MY330/81A MY8100330A (en) 1973-09-08 1981-12-30 1,3-diketo-1,2,3,4-tetrahydrosoquinolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2345422A DE2345422C2 (de) 1973-09-08 1973-09-08 Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
DE2345422A1 DE2345422A1 (de) 1975-03-20
DE2345422C2 true DE2345422C2 (de) 1983-12-22

Family

ID=5892058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2345422A Expired DE2345422C2 (de) 1973-09-08 1973-09-08 Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung

Country Status (5)

Country Link
BE (1) BE819651A (pl)
DE (1) DE2345422C2 (pl)
PL (2) PL96298B1 (pl)
SU (1) SU528035A3 (pl)
ZA (1) ZA745688B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004281750A1 (en) * 2003-10-14 2005-04-28 Wyeth Use of adrenergic alphaze antagonists for the treatment of vasomotor symptoms
ES2462240T3 (es) 2006-02-28 2014-05-22 Dart Neuroscience (Cayman) Ltd Piperazinas terapéuticas como inhibidores de PDE4
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines

Also Published As

Publication number Publication date
DE2345422A1 (de) 1975-03-20
SU528035A3 (ru) 1976-09-05
PL96297B1 (pl) 1977-12-31
PL96298B1 (pl) 1977-12-31
BE819651A (fr) 1975-03-06
ZA745688B (en) 1976-05-26

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Legal Events

Date Code Title Description
OD Request for examination
8126 Change of the secondary classification

Ipc: A61K 31/495

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee