FI52219C - Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia . - Google Patents

Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia .

Info

Publication number
FI52219C
FI52219C FI742465A FI246574A FI52219C FI 52219 C FI52219 C FI 52219C FI 742465 A FI742465 A FI 742465A FI 246574 A FI246574 A FI 246574A FI 52219 C FI52219 C FI 52219C
Authority
FI
Finland
Prior art keywords
antiarrhythmic
isoquinolin
sedative
antihypertensive
dioxo
Prior art date
Application number
FI742465A
Other languages
English (en)
Swedish (sv)
Other versions
FI52219B (fi
FI246574A (fi
Inventor
Eberhard Kutter
Volkhard Austel
Wolfgang Eberlein
Joachim Heider
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732345423 external-priority patent/DE2345423A1/de
Priority claimed from DE2345422A external-priority patent/DE2345422C2/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI246574A publication Critical patent/FI246574A/fi
Publication of FI52219B publication Critical patent/FI52219B/fi
Application granted granted Critical
Publication of FI52219C publication Critical patent/FI52219C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FI742465A 1973-09-08 1974-08-21 Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia . FI52219C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19732345423 DE2345423A1 (de) 1973-09-08 1973-09-08 Neue substituierte phenylaethylaminderivate, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
DE2345422A DE2345422C2 (de) 1973-09-08 1973-09-08 Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung

Publications (3)

Publication Number Publication Date
FI246574A FI246574A (fi) 1975-03-09
FI52219B FI52219B (fi) 1977-03-31
FI52219C true FI52219C (fi) 1977-07-11

Family

ID=25765764

Family Applications (1)

Application Number Title Priority Date Filing Date
FI742465A FI52219C (fi) 1973-09-08 1974-08-21 Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia .

Country Status (26)

Country Link
US (1) US3948898A (fi)
JP (1) JPS596868B2 (fi)
AT (1) AT330777B (fi)
BG (2) BG22390A3 (fi)
CA (1) CA1025869A (fi)
CH (2) CH605778A5 (fi)
CS (1) CS185660B2 (fi)
DD (1) DD115122A5 (fi)
DK (1) DK137124C (fi)
ES (3) ES429473A1 (fi)
FI (1) FI52219C (fi)
FR (1) FR2242979B1 (fi)
GB (1) GB1446791A (fi)
HK (1) HK4180A (fi)
HU (1) HU167869B (fi)
IE (1) IE40742B1 (fi)
IL (1) IL45609A (fi)
MY (1) MY8100330A (fi)
NL (1) NL176363C (fi)
NO (1) NO140978C (fi)
PH (1) PH12918A (fi)
PL (1) PL91712B1 (fi)
RO (1) RO63655A (fi)
SE (1) SE424863B (fi)
SU (2) SU545256A3 (fi)
YU (1) YU39928B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639718C2 (de) * 1976-09-03 1987-03-05 Dr. Karl Thomae Gmbh, 7950 Biberach 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
DE2702600A1 (de) * 1977-01-22 1978-07-27 Thomae Gmbh Dr K Neue aminoalkoxyphenyl-derivate
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
JPS6312877U (fi) * 1986-03-05 1988-01-27
US4876256A (en) * 1988-04-29 1989-10-24 Merck & Co., Inc. Alkylpiperazinylpyridines as hypoglycemic agents
US5169948A (en) * 1991-05-22 1992-12-08 American Home Products Corporation Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
SE9303274D0 (sv) * 1993-10-07 1993-10-07 Astra Ab Novel phenylethyl and phenylproplamines
WO1999021834A1 (en) 1997-10-27 1999-05-06 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
US20040152710A1 (en) * 2002-10-15 2004-08-05 Deecher Darlene Coleman Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
CA2595339C (en) * 2005-01-28 2014-08-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for producing isochromane and derivatives thereof
ES2462240T3 (es) * 2006-02-28 2014-05-22 Dart Neuroscience (Cayman) Ltd Piperazinas terapéuticas como inhibidores de PDE4
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
WO2023288039A1 (en) * 2021-07-16 2023-01-19 Denali Therapeutics Inc. Compounds, compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1185934A (en) * 1967-06-28 1970-03-25 Pfizer & Co C Derivatives of 1,3(2H,4H)-Dioxoisoquinoline and preparation thereof
SE368009B (fi) * 1971-09-16 1974-06-17 Kabi Ab
GB1424348A (en) * 1972-11-30 1976-02-11 Wyeth John & Brother Ltd Isoquinoline derivatives

Also Published As

Publication number Publication date
FR2242979A1 (fi) 1975-04-04
ATA651474A (de) 1975-10-15
GB1446791A (en) 1976-08-18
CS185660B2 (en) 1978-10-31
JPS596868B2 (ja) 1984-02-15
YU239174A (en) 1982-06-30
SE424863B (sv) 1982-08-16
ES429473A1 (es) 1976-09-01
FI52219B (fi) 1977-03-31
NL7411843A (nl) 1975-03-11
ES433958A1 (es) 1976-11-16
YU39928B (en) 1985-06-30
IE40742L (en) 1975-03-08
RO63655A (fr) 1978-10-15
IL45609A (en) 1977-07-31
BG26195A4 (bg) 1979-02-15
CA1025869A (en) 1978-02-07
ES433959A1 (es) 1976-11-16
IL45609A0 (en) 1974-11-29
FR2242979B1 (fi) 1978-02-03
DK137124B (da) 1978-01-23
BG22390A3 (bg) 1977-02-20
PL91712B1 (fi) 1977-03-31
NO140978C (no) 1979-12-19
PH12918A (en) 1979-10-10
CH605779A5 (fi) 1978-10-13
MY8100330A (en) 1981-12-31
IE40742B1 (en) 1979-08-15
DK137124C (da) 1978-06-26
HK4180A (en) 1980-02-08
NO743220L (fi) 1975-04-07
NO140978B (no) 1979-09-10
DD115122A5 (fi) 1975-09-12
NL176363B (nl) 1984-11-01
SU545256A3 (ru) 1977-01-30
SU538664A3 (ru) 1976-12-05
FI246574A (fi) 1975-03-09
CH605778A5 (fi) 1978-10-13
DK472774A (fi) 1975-05-05
NL176363C (nl) 1985-04-01
AT330777B (de) 1976-07-26
JPS5050381A (fi) 1975-05-06
HU167869B (fi) 1975-12-25
SE7411312L (fi) 1975-03-10
AU7302374A (en) 1976-03-11
US3948898A (en) 1976-04-06

Similar Documents

Publication Publication Date Title
SE435713B (sv) Forfarande for framstellning av 1,3-bensoxazoler
NO141898C (no) Fremgangsmaate for fremstilling av 6,7-dimetoksy-4-amino-2-(4-(2-furoyl)-piperazin-1-yl)-kinazolin
FI52219C (fi) Menetelmä valmistaa verenpainetta alentavia, antiarytmisiä ja rauhoitt avia 4,4-dimetyyli-1,3-diokso-(2H,4H)-isokinoliini-2-yyli johdannaisia .
SE420720B (sv) Forfarande for framstellning av 2,6-disubstuerade fenylaminoguanidinforeningar
DK134490B (da) Analogifremgangsmåde til fremstilling af 2,6-diaminonebularin-derivater.
DK133556B (da) Analogifremgangsmåde til fremstilling af 9-substituerede aminoimidazo/4,5-f/kinoliner.
NL7413536A (nl) Basisch gesubstitueerde 1,4-dihydro-2h-iso- chinolinederivaten en hun bereiding.
SE419443B (sv) Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat
SE416053B (sv) Forfarande for framstellning av 7alfa-metylostr-4-en-3alfa, 17beta-diol
NO740841L (no) Fremgangsmåte for fremstilling av 1-beta-D-ribofuranosyl-1, 2, 4-triazol-3-karboksamid.
SE419444B (sv) Forfarande for framstellning av nya 2,4-diamino-5-bensylpyrimidinderivat
SE410458B (sv) Forfarande for framstellning av vissa angivna 1,2,4-triazolderivat
BE816021A (fr) Procede de preparation de 2-aryl-as-triazine 3,5-(2h,4h)-diones.
SE401833B (sv) Forfarande for framstellnig av vissa angivna 1,2,4-friazolderivat
DK138895B (da) Fremgangsmåde til fremstilling af 8-beta-(2'-pyrimidino-aminometyl)-ergolinderivater.
SE412910B (sv) Forfarande for framstellning av derivat av 1,3-bensodioxol
SE420600B (sv) Forfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
SU502900A1 (ru) "Способ получени производных -алкилоксаазафосфоринанов-1,3,2
SE413025B (sv) Forfarande for framstellning av nya 6,7-bensomorfanderivat
NO138146C (no) Fremgangsmaate for fremstilling av 2,2`-anhydro-1beta-d-arabinfuranosyl-5-cytosin
AR204011A1 (es) Procedimiento de preparacion de nuevos derivados de 7-h-indolizino(5,6,7-ij)isoquinoleina
DK137726C (da) Fremgangsmaade til fremstilling af 4-amino-1,2,4-triazin-5-oner
SE401836B (sv) Forfarande for framstellning av 1,3-dietrar av 2-azaestratriener
SU478832A1 (ru) Способ получени производных 3метокси-4-оксатрицикло(5,2,1,0 ,6) -декан-5-спиро-2 -тетрагидрофурана
SE389868B (sv) Forfarande for framstellning av 2,4-diamino-5-bensyl-pyrimidiner