DE2337340C2 - 6-Chlor-α-methylcarbazol-2-essigsäure und deren Salze - Google Patents

6-Chlor-α-methylcarbazol-2-essigsäure und deren Salze

Info

Publication number
DE2337340C2
DE2337340C2 DE2337340A DE2337340A DE2337340C2 DE 2337340 C2 DE2337340 C2 DE 2337340C2 DE 2337340 A DE2337340 A DE 2337340A DE 2337340 A DE2337340 A DE 2337340A DE 2337340 C2 DE2337340 C2 DE 2337340C2
Authority
DE
Germany
Prior art keywords
acetic acid
chloro
methyl
solution
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2337340A
Other languages
German (de)
English (en)
Other versions
DE2337340A1 (de
Inventor
Leo Montclair N.J. Berger
Alfred John Wayne N.J. Corraz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2337340A1 publication Critical patent/DE2337340A1/de
Application granted granted Critical
Publication of DE2337340C2 publication Critical patent/DE2337340C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2337340A 1972-07-24 1973-07-23 6-Chlor-α-methylcarbazol-2-essigsäure und deren Salze Expired DE2337340C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27414272A 1972-07-24 1972-07-24

Publications (2)

Publication Number Publication Date
DE2337340A1 DE2337340A1 (de) 1974-02-14
DE2337340C2 true DE2337340C2 (de) 1985-05-02

Family

ID=23046965

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2337340A Expired DE2337340C2 (de) 1972-07-24 1973-07-23 6-Chlor-α-methylcarbazol-2-essigsäure und deren Salze

Country Status (26)

Country Link
JP (1) JPS5740144B2 (show.php)
KR (1) KR780000289B1 (show.php)
AR (1) AR205331A1 (show.php)
AT (1) AT325607B (show.php)
AU (1) AU475534B2 (show.php)
BE (1) BE802596A (show.php)
CA (1) CA1026348A (show.php)
CH (1) CH587819A5 (show.php)
DD (1) DD107681A5 (show.php)
DE (1) DE2337340C2 (show.php)
DK (1) DK138537B (show.php)
FI (1) FI59244C (show.php)
FR (1) FR2193611B1 (show.php)
GB (1) GB1385620A (show.php)
HK (1) HK49878A (show.php)
HU (1) HU167611B (show.php)
IE (1) IE37942B1 (show.php)
IL (1) IL42799A (show.php)
KE (1) KE2847A (show.php)
LU (1) LU68071A1 (show.php)
MY (1) MY7800315A (show.php)
NL (1) NL169877C (show.php)
NO (1) NO142865C (show.php)
SE (2) SE402283B (show.php)
SU (1) SU509220A3 (show.php)
ZA (1) ZA734047B (show.php)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146542A (en) * 1978-06-12 1979-03-27 Hoffmann-La Roche Inc. Dihydrocarbazole acetic acid and esters thereof
US4150031A (en) * 1978-06-26 1979-04-17 Hoffmann-La Roche Inc. Hydroxy methyl carbazole acetic acid and esters
US4158007A (en) * 1978-08-21 1979-06-12 Hoffmann-La Roche Inc. Carbazole methyl malonates
US4501908A (en) * 1981-03-12 1985-02-26 Hoffmann-La Roche Inc. 2,3-Isopropylidene ribonic acid, 1,4-lactones
JPS6040256U (ja) * 1983-08-25 1985-03-20 伊東　璋 容器類洗浄機
ATE61047T1 (de) * 1986-01-23 1991-03-15 Merck Frosst Canada Inc Tetrahydrocarbazol-1-alkansaeuren.
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
CA1326030C (en) * 1987-07-21 1994-01-11 John W. Gillard Cyclohept[b]indolealkanoic acids
EP0307077A1 (en) * 1987-07-21 1989-03-15 Merck Frosst Canada Inc. Tetrahydrocarbazoles for the improvement of cyclosporin therapy
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US6013808A (en) * 1998-06-16 2000-01-11 Pfizer Inc. Method of purifying carbazole ester precursors of 6-chloro-α-methyl-carbazole-2-acetic acid
JP2004010601A (ja) * 2002-06-11 2004-01-15 Nippon Steel Chem Co Ltd インドール誘導体の製造方法及びそのための有用な中間体
EP1587798A4 (en) * 2003-01-14 2007-06-27 Merck & Co Inc GEMINAL DISUBSTITUTED SODIUM DERIVATIVES AS ABETA 42 SUBSTITUTING AGENTS
EP1660404B1 (en) * 2003-05-06 2015-08-05 Air Products And Chemicals, Inc. Hydrogen storage reversible hydrogenated of pi-conjugated substrates
WO2005016882A1 (en) * 2003-08-15 2005-02-24 Universite Laval Monomers, oligomers and polymers of 2-functionalized and 2,7-difunctionalized carbazoles
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
US9447040B2 (en) * 2011-11-15 2016-09-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Tricyclic compounds, compositions comprising them and uses thereof
JP5940036B2 (ja) * 2013-10-08 2016-06-29 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
TWI856246B (zh) * 2020-03-25 2024-09-21 日商捷恩智股份有限公司 化合物、液晶組成物及液晶顯示元件

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70880A (show.php) *
US3580926A (en) * 1969-11-10 1971-05-25 Parke Davis & Co Carbazole-4-alkanoic acids and tetrahydrocarbazole-4-alkanoic acids
ZA715217B (en) * 1970-08-20 1972-04-26 Org Nv Anti-inflammatory preparations

Also Published As

Publication number Publication date
ZA734047B (en) 1974-03-27
JPS5740144B2 (show.php) 1982-08-25
KE2847A (en) 1978-06-30
IL42799A0 (en) 1973-10-25
NO142865B (no) 1980-07-28
MY7800315A (en) 1978-12-31
FI59244B (fi) 1981-03-31
SE7605813L (sv) 1976-05-21
BE802596A (fr) 1974-01-21
AT325607B (de) 1975-10-27
HK49878A (en) 1978-09-08
IE37942L (en) 1974-01-24
DK138537B (da) 1978-09-25
GB1385620A (en) 1975-02-26
IL42799A (en) 1977-03-31
NL7310275A (show.php) 1974-01-28
SU509220A3 (ru) 1976-03-30
CH587819A5 (show.php) 1977-05-13
DD107681A5 (show.php) 1974-08-12
AU5839073A (en) 1975-01-23
KR780000289B1 (en) 1978-08-10
CA1026348A (en) 1978-02-14
SE402283B (sv) 1978-06-26
IE37942B1 (en) 1977-11-23
NL169877B (nl) 1982-04-01
DE2337340A1 (de) 1974-02-14
LU68071A1 (show.php) 1975-04-11
FR2193611B1 (show.php) 1976-05-14
FI59244C (fi) 1981-07-10
FR2193611A1 (show.php) 1974-02-22
AR205331A1 (es) 1976-04-30
AU475534B2 (en) 1976-08-26
DK138537C (show.php) 1979-03-05
JPS4943973A (show.php) 1974-04-25
NL169877C (nl) 1982-09-01
HU167611B (show.php) 1975-11-28
NO142865C (no) 1980-11-05
ATA649773A (de) 1975-01-15

Similar Documents

Publication Publication Date Title
DE2337340C2 (de) 6-Chlor-α-methylcarbazol-2-essigsäure und deren Salze
DE2365967C3 (de) 3-[Piperidyl-(4)]-indole, ihre Herstellung und Verwendung
DE2166381C3 (de) γ-Piperidinobutyrophenonderivate, Verfahren zu i hrer Herstellung und Arzneipräparate
DE1963182A1 (de) Neue N-Phenylindolin-Derivate und deren Verwendung als Arzneimittel
DE2628570A1 (de) 10- eckige klammer auf omega- (benzoylpiperidinyl)-alkyl eckige klammer zu phenothiazine und verfahren zu ihrer herstellung
DE1445878A1 (de) Verfahren zur Herstellung von Benzodiazepin-Derivaten
DE2229223C3 (de) 2-Nitro-S-imidazol-Derivate und Verfahren zu deren Herstellung
DE2230154A1 (de) N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
DE2747987C2 (show.php)
DE2160911A1 (de) Verfahren zur Herstellung von Aminoketonen
DE1545947A1 (de) Verfahren zur Herstellung von Iminodibenzyl-Derivaten
DE2065311C3 (de) v-(4-Hydroxy-4-phenylpiperidino)- 2-amino-4fluorbutyrophenone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2065707C3 (de) Gama-Piperidino-2-halobutyrophenon-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
EP0020941A1 (de) Substituierte 3-(1-Pyrrolidinyl)-5-sulfamoyl-benzoesäure-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Zubereitungen, die sie enthalten und Verfahren zu deren Herstellung
DE1518654A1 (de) Neue Cycloheptadiene
DE1695080A1 (de) Verfahren zur Herstellung von neuen N-heterocyclischen Verbindungen
DE2114511C3 (de) 2-Alkyl-6,7-benzomorphane, Verfahren zu ihrer Herstellung und ihre Weiterverarbeitung zu 2-BenzoaIkyl-6,7-benzomorphanen
AT247318B (de) Verfahren zur Herstellung neuer Imidazole
DE1645988C3 (de) 23-Dihydro-lH-pyrido [2,3-b] [1,4] -thiazine und Verfahren zu deren Herstellung
DE2157299A1 (de) Anthrachinonverbindungen, deren phar makologisch vertragliche Salze, Verfahren zu ihrer Herstellung und diese Verbindun gen enthaltende Arzneipraparate
DE2113254C3 (de) Verfahren zur Herstellung von γ-Piperidinoburyrophenonderivaten
AT263790B (de) Verfahren zur Herstellung von neuen 2,3,4,5-Tetrahydro-1,4-benzoxazepinen, von deren Salzen und optisch isomeren Formen
DE2222833A1 (de) Cyclopenteno-chinolonderivate und verfahren zur herstellung derselben
AT299191B (de) Verfahren zur Herstellung neuer 1-Aminoäthyl-indole bzw. von Salzen hievon
DE1032257B (de) Verfahren zur Herstellung neuer Hydantoine

Legal Events

Date Code Title Description
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT