DE2335216A1 - Arzneimittel zur foerderung der proteinsynthese und zur unterdrueckung der harnstoffbildung - Google Patents
Arzneimittel zur foerderung der proteinsynthese und zur unterdrueckung der harnstoffbildungInfo
- Publication number
- DE2335216A1 DE2335216A1 DE19732335216 DE2335216A DE2335216A1 DE 2335216 A1 DE2335216 A1 DE 2335216A1 DE 19732335216 DE19732335216 DE 19732335216 DE 2335216 A DE2335216 A DE 2335216A DE 2335216 A1 DE2335216 A1 DE 2335216A1
- Authority
- DE
- Germany
- Prior art keywords
- medicament according
- hydroxy
- acid
- protein
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000015572 biosynthetic process Effects 0.000 title claims description 25
- 238000001243 protein synthesis Methods 0.000 title claims description 11
- 230000014616 translation Effects 0.000 title claims description 11
- 229940126601 medicinal product Drugs 0.000 title claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 74
- 239000003814 drug Substances 0.000 claims description 52
- 238000011282 treatment Methods 0.000 claims description 39
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- 229940024606 amino acid Drugs 0.000 claims description 33
- 235000001014 amino acid Nutrition 0.000 claims description 33
- 150000001413 amino acids Chemical class 0.000 claims description 33
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 20
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 19
- 159000000007 calcium salts Chemical class 0.000 claims description 16
- BTNMPGBKDVTSJY-UHFFFAOYSA-N keto-phenylpyruvic acid Chemical compound OC(=O)C(=O)CC1=CC=CC=C1 BTNMPGBKDVTSJY-UHFFFAOYSA-N 0.000 claims description 16
- 229960002885 histidine Drugs 0.000 claims description 14
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 12
- 208000008425 Protein deficiency Diseases 0.000 claims description 12
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- 229940079593 drug Drugs 0.000 claims description 12
- 229960002898 threonine Drugs 0.000 claims description 12
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 9
- 239000001903 2-oxo-3-phenylpropanoic acid Substances 0.000 claims description 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 8
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 8
- DEDGUGJNLNLJSR-UHFFFAOYSA-N alpha-hydroxycinnamic acid Natural products OC(=O)C(O)=CC1=CC=CC=C1 DEDGUGJNLNLJSR-UHFFFAOYSA-N 0.000 claims description 8
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
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- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims description 4
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- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35532673A | 1973-04-30 | 1973-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2335216A1 true DE2335216A1 (de) | 1974-11-21 |
Family
ID=23397057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732335216 Pending DE2335216A1 (de) | 1973-04-30 | 1973-07-11 | Arzneimittel zur foerderung der proteinsynthese und zur unterdrueckung der harnstoffbildung |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS49135966A (enrdf_load_stackoverflow) |
| BE (1) | BE803567A (enrdf_load_stackoverflow) |
| CA (1) | CA1023664A (enrdf_load_stackoverflow) |
| DE (1) | DE2335216A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2226994B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1442154A (enrdf_load_stackoverflow) |
| IL (1) | IL42787A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2556100A1 (de) * | 1975-02-03 | 1976-08-05 | American Hospital Supply Corp | Aminosaeurepraeparate fuer leberkranke patienten |
| DE2530246A1 (de) * | 1975-07-07 | 1977-01-13 | Fresenius Chem Pharm Ind | L-aminosaeuregemische fuer parenterale oder orale anwendung |
| DE2531299A1 (de) * | 1975-07-12 | 1977-01-13 | Fresenius Chem Pharm Ind | L-amino- und hydroxy- und/oder ketosaeuren enthaltende gemische fuer parenterale oder orale anwendung |
| DE2636828A1 (de) * | 1976-08-16 | 1978-02-23 | Fresenius Chem Pharm Ind | L-amonosaeurengemische fuer die behandlung von leberinsuffizienz sowie die herstellung derartiger gemische |
| DE3015076A1 (de) * | 1979-04-18 | 1980-10-30 | Univ Johns Hopkins | Mischsalze aus essentiellen oder halbessentiellen aminosaeuren und deren stickstoff-freien analoga, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| WO1990002726A1 (en) * | 1988-09-07 | 1990-03-22 | Kabivitrum Ab | Alternative energy substrate |
| DE3943424A1 (de) * | 1989-12-30 | 1991-07-04 | Nephro Medica Pharma | Infusions- und injektionsloesung zur intravenoesen verabreichung |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752619A (en) * | 1985-12-23 | 1988-06-21 | The Johns Hopkins University | Nutritional supplement for treatment of uremia |
| CN103476275A (zh) * | 2011-04-18 | 2013-12-25 | 雀巢产品技术援助有限公司 | 包含α-羟基异己酸的营养组合物 |
-
1973
- 1973-07-05 GB GB3212173A patent/GB1442154A/en not_active Expired
- 1973-07-11 DE DE19732335216 patent/DE2335216A1/de active Pending
- 1973-07-12 CA CA176,338A patent/CA1023664A/en not_active Expired
- 1973-07-19 IL IL42787A patent/IL42787A/en unknown
- 1973-08-03 FR FR7328498A patent/FR2226994B1/fr not_active Expired
- 1973-08-14 BE BE2052988A patent/BE803567A/xx not_active IP Right Cessation
- 1973-10-11 JP JP48114328A patent/JPS49135966A/ja active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2556100A1 (de) * | 1975-02-03 | 1976-08-05 | American Hospital Supply Corp | Aminosaeurepraeparate fuer leberkranke patienten |
| DE2530246A1 (de) * | 1975-07-07 | 1977-01-13 | Fresenius Chem Pharm Ind | L-aminosaeuregemische fuer parenterale oder orale anwendung |
| DE2531299A1 (de) * | 1975-07-12 | 1977-01-13 | Fresenius Chem Pharm Ind | L-amino- und hydroxy- und/oder ketosaeuren enthaltende gemische fuer parenterale oder orale anwendung |
| DE2636828A1 (de) * | 1976-08-16 | 1978-02-23 | Fresenius Chem Pharm Ind | L-amonosaeurengemische fuer die behandlung von leberinsuffizienz sowie die herstellung derartiger gemische |
| DE3015076A1 (de) * | 1979-04-18 | 1980-10-30 | Univ Johns Hopkins | Mischsalze aus essentiellen oder halbessentiellen aminosaeuren und deren stickstoff-freien analoga, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| WO1990002726A1 (en) * | 1988-09-07 | 1990-03-22 | Kabivitrum Ab | Alternative energy substrate |
| EP0366632A1 (en) * | 1988-09-07 | 1990-05-02 | Kabivitrum Ab | Alternative energy substrates |
| DE3943424A1 (de) * | 1989-12-30 | 1991-07-04 | Nephro Medica Pharma | Infusions- und injektionsloesung zur intravenoesen verabreichung |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6015373A (en) | 1975-03-13 |
| FR2226994A1 (enrdf_load_stackoverflow) | 1974-11-22 |
| JPS49135966A (enrdf_load_stackoverflow) | 1974-12-27 |
| IL42787A0 (en) | 1973-10-25 |
| GB1442154A (en) | 1976-07-07 |
| CA1023664A (en) | 1978-01-03 |
| BE803567A (fr) | 1973-12-03 |
| IL42787A (en) | 1977-05-31 |
| FR2226994B1 (enrdf_load_stackoverflow) | 1977-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal | ||
| OI | Miscellaneous see part 1 |