DE2331665C2 - 2-(6-Methoxy-2-naphthyl)-propionsäure-ester, bzw. ihre Säureadditionssalze, Verfahren zu deren Herstellung und Arzneimittel auf der Basis dieser Verbindungen - Google Patents

2-(6-Methoxy-2-naphthyl)-propionsäure-ester, bzw. ihre Säureadditionssalze, Verfahren zu deren Herstellung und Arzneimittel auf der Basis dieser Verbindungen

Info

Publication number
DE2331665C2
DE2331665C2 DE2331665A DE2331665A DE2331665C2 DE 2331665 C2 DE2331665 C2 DE 2331665C2 DE 2331665 A DE2331665 A DE 2331665A DE 2331665 A DE2331665 A DE 2331665A DE 2331665 C2 DE2331665 C2 DE 2331665C2
Authority
DE
Germany
Prior art keywords
methoxy
naphthyl
compounds
propionic acid
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2331665A
Other languages
German (de)
English (en)
Other versions
DE2331665A1 (de
Inventor
Michael Palo Alto Calif. Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of DE2331665A1 publication Critical patent/DE2331665A1/de
Application granted granted Critical
Publication of DE2331665C2 publication Critical patent/DE2331665C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D233/14—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE2331665A 1972-06-27 1973-06-22 2-(6-Methoxy-2-naphthyl)-propionsäure-ester, bzw. ihre Säureadditionssalze, Verfahren zu deren Herstellung und Arzneimittel auf der Basis dieser Verbindungen Expired DE2331665C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26664072A 1972-06-27 1972-06-27

Publications (2)

Publication Number Publication Date
DE2331665A1 DE2331665A1 (de) 1974-01-17
DE2331665C2 true DE2331665C2 (de) 1983-04-21

Family

ID=23015387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2331665A Expired DE2331665C2 (de) 1972-06-27 1973-06-22 2-(6-Methoxy-2-naphthyl)-propionsäure-ester, bzw. ihre Säureadditionssalze, Verfahren zu deren Herstellung und Arzneimittel auf der Basis dieser Verbindungen

Country Status (13)

Country Link
JP (1) JPS5438097B2 (xx)
AT (1) AT323145B (xx)
AU (1) AU472375B2 (xx)
BE (1) BE801440A (xx)
CA (1) CA1012159A (xx)
CH (1) CH581605A5 (xx)
DE (1) DE2331665C2 (xx)
ES (1) ES416311A1 (xx)
FR (1) FR2190451B1 (xx)
GB (1) GB1377316A (xx)
IL (1) IL42472A (xx)
NL (1) NL175910C (xx)
ZA (1) ZA733992B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1508988A (en) * 1987-04-27 1988-10-27 Syntex Pharmaceuticals International Ltd. Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs
CA2660814C (en) * 2006-08-15 2017-07-18 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
KR101366296B1 (ko) * 2012-03-07 2014-02-21 주식회사 포스코 내화재 축조 방법
JP6290947B2 (ja) * 2016-02-05 2018-03-07 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI41272B (xx) * 1963-05-02 1969-06-30 Parke Davis & Co
ZA701191B (en) * 1969-03-24 1971-09-29 Syntex Corp 2-(6-substituted-2'-naphthyl)acetic acid esters and process for producing same

Also Published As

Publication number Publication date
FR2190451B1 (xx) 1976-12-31
JPS5438097B2 (xx) 1979-11-19
BE801440A (fr) 1973-12-26
FR2190451A1 (xx) 1974-02-01
ZA733992B (en) 1975-01-29
NL175910C (nl) 1985-01-16
NL7308876A (xx) 1974-01-02
CA1012159A (en) 1977-06-14
AU472375B2 (en) 1976-05-20
CH581605A5 (xx) 1976-11-15
JPS504053A (xx) 1975-01-16
ES416311A1 (es) 1976-05-16
NL175910B (nl) 1984-08-16
IL42472A0 (en) 1973-08-29
AT323145B (de) 1975-06-25
IL42472A (en) 1977-01-31
AU5690373A (en) 1974-12-19
GB1377316A (en) 1974-12-11
DE2331665A1 (de) 1974-01-17

Similar Documents

Publication Publication Date Title
DE1595915C3 (de) Pyrrolidinderivate
DE2845499A1 (de) Alkanoylprolin-derivate und deren homologen, ihre herstellung und verwendung
CH633249A5 (de) Verfahren zur herstellung von neuen polyprenylderivaten.
DE3141586A1 (de) 1,8-dihydroxy-9-anthron-derivate, verfahren zu ihrer herstellung und ihre verwendung in der pharmazie und kosmetik
DE2616616A1 (de) 1-(triarylalklyl)-4-phenylpiperidinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die diese verbindungen enthalten
EP0110869B1 (de) Thienylessigsäureamidderivate und pharmazeutisch verträgliche Säureadditionssalze hiervon sowie Verfahren zu deren Herstellung
DE2331665C2 (de) 2-(6-Methoxy-2-naphthyl)-propionsäure-ester, bzw. ihre Säureadditionssalze, Verfahren zu deren Herstellung und Arzneimittel auf der Basis dieser Verbindungen
DE2446100C3 (de) Phenoxyalkancarbonsäureamide von Thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel
DE2128375B2 (de) Basische substituierte Alkylidenamino-oxyalkyl-carbonsäureester, deren Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
WO1979000426A1 (en) Cyclic diamine n,n'-disubstituted and process for preparing the same
DE2812353A1 (de) Oxazol- und thiazol-alkansaeureverbindungen, verfahren zu ihrer herstellung und sie enthaltendes pharmazeutisches mittel
DD154816B3 (de) Verfahren zur herstellung neuer pyridine
DE2425767A1 (de) 3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazole und ihre verwendung in arzneimitteln
CH574921A5 (en) Anti-inflammatory alpha-aminophenyl carboxylic acids
DE3113087C2 (de) 1,4-Disubstituierte Piperazine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2640884A1 (de) Neue entzuendungshemmende l-oxo-isoindolin-derivate und verfahren zu ihrer herstellung
DE1470002A1 (de) 5,6-Dihydromorphanthridinderivate
DE2934375A1 (de) Hydroxyessigsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
EP0011092A1 (de) Alpha-Aminophenylessigsäurederivate zur Verwendung bei der Behandlung von Entzündungen sowie neue alpha-Aminophenylessigsäurederivate
DE2833892A1 (de) 12h-dibenzo eckige klammer auf d,g eckige klammer zu eckige klammer auf 1,3,6 eckige klammer zu dioxazocinderivate, solche enthaltende arzneimittel und verfahren zur herstellung derselben
DE2639935A1 (de) Benzoesaeuren und verfahren zu ihrer herstellung
AT354432B (de) Verfahren zur herstellung von 3-indolylessig- saeuren
AT295516B (de) Verfahren zur Herstellung neuer cyclischer Amidine und ihrer Salze
DE1568253C (de) N substituierte 1,2 Diphenyl 2 acyloxy 3 amino methyl butene
DE2362877A1 (de) 5,8-dihydro-5,8-methanonaphthaline mit kardiovaskulaerer wirkung

Legal Events

Date Code Title Description
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee