DE2314059A1 - Verbesserte substanz fuer das markieren mit technetium-99m sowie verfahren zu deren herstellung - Google Patents
Verbesserte substanz fuer das markieren mit technetium-99m sowie verfahren zu deren herstellungInfo
- Publication number
- DE2314059A1 DE2314059A1 DE19732314059 DE2314059A DE2314059A1 DE 2314059 A1 DE2314059 A1 DE 2314059A1 DE 19732314059 DE19732314059 DE 19732314059 DE 2314059 A DE2314059 A DE 2314059A DE 2314059 A1 DE2314059 A1 DE 2314059A1
- Authority
- DE
- Germany
- Prior art keywords
- macroprotein
- particles
- technetium
- denatured
- tin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims description 21
- 229940056501 technetium 99m Drugs 0.000 title claims description 21
- 239000000126 substance Substances 0.000 title claims description 20
- 238000004519 manufacturing process Methods 0.000 title description 7
- 239000002245 particle Substances 0.000 claims description 37
- 102000004169 proteins and genes Human genes 0.000 claims description 33
- 108090000623 proteins and genes Proteins 0.000 claims description 33
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 29
- 210000004072 lung Anatomy 0.000 claims description 27
- 239000000243 solution Substances 0.000 claims description 22
- 239000007853 buffer solution Substances 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 8
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 8
- 229940102213 injectable suspension Drugs 0.000 claims description 8
- 239000004005 microsphere Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 229910001432 tin ion Inorganic materials 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000005054 agglomeration Methods 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- GSJBKPNSLRKRNR-UHFFFAOYSA-N $l^{2}-stannanylidenetin Chemical compound [Sn].[Sn] GSJBKPNSLRKRNR-UHFFFAOYSA-N 0.000 claims 1
- 241000219492 Quercus Species 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 31
- 239000000725 suspension Substances 0.000 description 30
- 102000009027 Albumins Human genes 0.000 description 19
- 108010088751 Albumins Proteins 0.000 description 19
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 18
- 229910052713 technetium Inorganic materials 0.000 description 14
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 238000002372 labelling Methods 0.000 description 7
- 235000019445 benzyl alcohol Nutrition 0.000 description 6
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 5
- 239000008351 acetate buffer Substances 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002559 palpation Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003006 anti-agglomeration agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 108010013207 macro aggregates of albumin Proteins 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- JEHASHUIFUSSAI-UHFFFAOYSA-N sulfanylidenetechnetium Chemical compound [Tc]=S JEHASHUIFUSSAI-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- FAKFSJNVVCGEEI-UHFFFAOYSA-J tin(4+);disulfate Chemical compound [Sn+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O FAKFSJNVVCGEEI-UHFFFAOYSA-J 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US236159A US3863004A (en) | 1972-03-20 | 1972-03-20 | Denatured macroprotein with divalent tin for tagging with technetium-99m and method of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2314059A1 true DE2314059A1 (de) | 1973-10-04 |
Family
ID=22888369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732314059 Withdrawn DE2314059A1 (de) | 1972-03-20 | 1973-03-19 | Verbesserte substanz fuer das markieren mit technetium-99m sowie verfahren zu deren herstellung |
Country Status (10)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2710728A1 (de) * | 1976-03-19 | 1977-09-29 | Radiochemical Centre Ltd | Reagens fuer die radiologische abtastung von organen, verfahren zu seiner herstellung und seine verwendung |
| DE2814038A1 (de) * | 1977-04-01 | 1978-10-05 | New England Nuclear Corp | Zur verwendung mit einem radionuklid bestimmtes albuminhaltiges diagnostikum |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3968221A (en) * | 1972-05-05 | 1976-07-06 | Medi-Physics, Inc. | 99M-Technetium labeled tin colloid radiopharmaceuticals |
| US4024233A (en) * | 1972-06-05 | 1977-05-17 | Medi-Physics, Inc. | 99M-technetium labeled macroaggregated human serum albumin pharmaceutical |
| US3987157A (en) * | 1974-08-29 | 1976-10-19 | Union Carbide Corporation | Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation |
| US3992513A (en) * | 1975-01-07 | 1976-11-16 | Atomic Energy Of Canada Limited | Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs |
| US4057617A (en) * | 1975-05-15 | 1977-11-08 | Abramovici J | Method of labeling proteins with technetium |
| US4226846A (en) * | 1977-04-01 | 1980-10-07 | New England Nuclear Corporation | Albumin microaggregates for radioactive scanning of reticuloendothelial systems |
| US4337240A (en) * | 1978-04-20 | 1982-06-29 | New England Nuclear Corporation | Denatured albumin complexes for radioscintigraphic imaging and evaluation of reticuloendothelial systems |
| DE3060377D1 (en) * | 1979-08-29 | 1982-07-01 | Nihon Mediphysics Co Ltd | 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use |
| JPS5645790U (enrdf_load_stackoverflow) * | 1979-09-17 | 1981-04-24 | ||
| US4406876A (en) * | 1980-10-14 | 1983-09-27 | Research Foundation Of The State Univ. Of New York | Sulfur free small-particle production of technetium sulfur colloid |
| IT1194135B (it) * | 1981-01-05 | 1988-09-14 | Novo Industri As | Composizioni di plasmina stabilizzata e metodo per la loro preparazione |
| CH652599A5 (de) * | 1981-08-28 | 1985-11-29 | Solco Basel Ag | Verfahren zur herstellung physiologisch abbaubarer kolloidaler, human-serumalbumin enthaltender produkte und ihre verwendung. |
| JPS61103841A (ja) * | 1984-10-26 | 1986-05-22 | Nippon Mejifuijitsukusu Kk | 放射性テクネチウム標識に供する安定な塩化第一スズ組成物 |
| US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| US5071965A (en) * | 1988-07-19 | 1991-12-10 | Mallinckrodt Medical, Inc. | Novel tc-99m complexes |
| US5096696A (en) * | 1990-02-05 | 1992-03-17 | The Research Foundation Of State University Of New York | Binding of radiolabeled albumin fragments to fibrin clots |
| US5137709A (en) * | 1991-02-15 | 1992-08-11 | The Dow Chemical Company | Layered mixed metal hydroxides for the stabilization of radioactive colloids |
| US5306482A (en) * | 1991-04-09 | 1994-04-26 | Merck Frosst Canada, Inc. | Radiopharmaceutical bacteriostats |
| GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| AU3783893A (en) * | 1992-02-28 | 1993-09-13 | Stanley E. Order | Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor |
| US6730286B2 (en) * | 2001-02-28 | 2004-05-04 | Bracco Diagnostics, Inc. | Manufacturing process to control particle size |
| DE10317461A1 (de) * | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung |
| FI20040240A0 (fi) * | 2004-02-13 | 2004-02-13 | Nokia Corp | Laskutusinformaation tuottaminen viestintäjärjestelmässä |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3663686A (en) * | 1968-04-24 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable radioactive particles |
| US3663687A (en) * | 1968-06-26 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable parenteral microspherules |
| US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
| CS208162B2 (en) * | 1971-07-20 | 1981-08-31 | Thomas A Haney | Method of making the macroagregates of the technicium-99m,albumine and tin ion |
-
1972
- 1972-03-20 US US236159A patent/US3863004A/en not_active Expired - Lifetime
-
1973
- 1973-03-13 GB GB1188673A patent/GB1409176A/en not_active Expired
- 1973-03-13 IL IL41767A patent/IL41767A/en unknown
- 1973-03-16 AU AU53375/73A patent/AU472255B2/en not_active Expired
- 1973-03-19 DE DE19732314059 patent/DE2314059A1/de not_active Withdrawn
- 1973-03-19 NL NL7303842A patent/NL7303842A/xx unknown
- 1973-03-19 BE BE1004909A patent/BE796962A/xx unknown
- 1973-03-20 IT IT48899/73A patent/IT989625B/it active
- 1973-03-20 FR FR7309886A patent/FR2182880B1/fr not_active Expired
- 1973-03-20 JP JP3253773A patent/JPS5328971B2/ja not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2710728A1 (de) * | 1976-03-19 | 1977-09-29 | Radiochemical Centre Ltd | Reagens fuer die radiologische abtastung von organen, verfahren zu seiner herstellung und seine verwendung |
| DE2814038A1 (de) * | 1977-04-01 | 1978-10-05 | New England Nuclear Corp | Zur verwendung mit einem radionuklid bestimmtes albuminhaltiges diagnostikum |
Also Published As
| Publication number | Publication date |
|---|---|
| BE796962A (fr) | 1973-09-19 |
| IL41767A (en) | 1976-06-30 |
| JPS5328971B2 (enrdf_load_stackoverflow) | 1978-08-17 |
| AU472255B2 (en) | 1976-05-20 |
| FR2182880A1 (enrdf_load_stackoverflow) | 1973-12-14 |
| FR2182880B1 (enrdf_load_stackoverflow) | 1976-04-09 |
| GB1409176A (en) | 1975-10-08 |
| IT989625B (it) | 1975-06-10 |
| JPS4954517A (enrdf_load_stackoverflow) | 1974-05-27 |
| NL7303842A (enrdf_load_stackoverflow) | 1973-09-24 |
| AU5337573A (en) | 1974-09-19 |
| IL41767A0 (en) | 1973-05-31 |
| US3863004A (en) | 1975-01-28 |
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