FR2182880A1 - - Google Patents

Info

Publication number
FR2182880A1
FR2182880A1 FR7309886A FR7309886A FR2182880A1 FR 2182880 A1 FR2182880 A1 FR 2182880A1 FR 7309886 A FR7309886 A FR 7309886A FR 7309886 A FR7309886 A FR 7309886A FR 2182880 A1 FR2182880 A1 FR 2182880A1
Authority
FR
France
Prior art keywords
macroprotein
denatured
divalent tin
injectable suspension
macroaggregates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7309886A
Other languages
English (en)
French (fr)
Other versions
FR2182880B1 (enrdf_load_stackoverflow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Chemical Works
Original Assignee
Mallinckrodt Chemical Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Chemical Works filed Critical Mallinckrodt Chemical Works
Publication of FR2182880A1 publication Critical patent/FR2182880A1/fr
Application granted granted Critical
Publication of FR2182880B1 publication Critical patent/FR2182880B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR7309886A 1972-03-20 1973-03-20 Expired FR2182880B1 (enrdf_load_stackoverflow)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US236159A US3863004A (en) 1972-03-20 1972-03-20 Denatured macroprotein with divalent tin for tagging with technetium-99m and method of preparation

Publications (2)

Publication Number Publication Date
FR2182880A1 true FR2182880A1 (enrdf_load_stackoverflow) 1973-12-14
FR2182880B1 FR2182880B1 (enrdf_load_stackoverflow) 1976-04-09

Family

ID=22888369

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7309886A Expired FR2182880B1 (enrdf_load_stackoverflow) 1972-03-20 1973-03-20

Country Status (10)

Country Link
US (1) US3863004A (enrdf_load_stackoverflow)
JP (1) JPS5328971B2 (enrdf_load_stackoverflow)
AU (1) AU472255B2 (enrdf_load_stackoverflow)
BE (1) BE796962A (enrdf_load_stackoverflow)
DE (1) DE2314059A1 (enrdf_load_stackoverflow)
FR (1) FR2182880B1 (enrdf_load_stackoverflow)
GB (1) GB1409176A (enrdf_load_stackoverflow)
IL (1) IL41767A (enrdf_load_stackoverflow)
IT (1) IT989625B (enrdf_load_stackoverflow)
NL (1) NL7303842A (enrdf_load_stackoverflow)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2366021A1 (fr) * 1974-08-29 1978-04-28 Union Carbide Corp Procede de preparation d'un support non radioactif stable destine au radiodiagnostic et consistant en un macro-agregat d'albumine
EP0508724A1 (en) * 1991-04-09 1992-10-14 Merck Frosst Canada Inc. Radiopharmaceutical bacteriostats
WO1993016735A1 (en) * 1992-02-28 1993-09-02 Order Stanley E Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968221A (en) * 1972-05-05 1976-07-06 Medi-Physics, Inc. 99M-Technetium labeled tin colloid radiopharmaceuticals
US4024233A (en) * 1972-06-05 1977-05-17 Medi-Physics, Inc. 99M-technetium labeled macroaggregated human serum albumin pharmaceutical
US3992513A (en) * 1975-01-07 1976-11-16 Atomic Energy Of Canada Limited Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs
US4057617A (en) * 1975-05-15 1977-11-08 Abramovici J Method of labeling proteins with technetium
GB1535847A (en) * 1976-03-19 1978-12-13 Radiochemical Centre Ltd Technetium-99m labelled tin colloid for body scanning
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same
US4226846A (en) * 1977-04-01 1980-10-07 New England Nuclear Corporation Albumin microaggregates for radioactive scanning of reticuloendothelial systems
US4337240A (en) * 1978-04-20 1982-06-29 New England Nuclear Corporation Denatured albumin complexes for radioscintigraphic imaging and evaluation of reticuloendothelial systems
DE3060377D1 (en) * 1979-08-29 1982-07-01 Nihon Mediphysics Co Ltd 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
JPS5645790U (enrdf_load_stackoverflow) * 1979-09-17 1981-04-24
US4406876A (en) * 1980-10-14 1983-09-27 Research Foundation Of The State Univ. Of New York Sulfur free small-particle production of technetium sulfur colloid
IT1194135B (it) * 1981-01-05 1988-09-14 Novo Industri As Composizioni di plasmina stabilizzata e metodo per la loro preparazione
CH652599A5 (de) * 1981-08-28 1985-11-29 Solco Basel Ag Verfahren zur herstellung physiologisch abbaubarer kolloidaler, human-serumalbumin enthaltender produkte und ihre verwendung.
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US5071965A (en) * 1988-07-19 1991-12-10 Mallinckrodt Medical, Inc. Novel tc-99m complexes
US5096696A (en) * 1990-02-05 1992-03-17 The Research Foundation Of State University Of New York Binding of radiolabeled albumin fragments to fibrin clots
US5137709A (en) * 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US6730286B2 (en) * 2001-02-28 2004-05-04 Bracco Diagnostics, Inc. Manufacturing process to control particle size
DE10317461A1 (de) * 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
FI20040240A0 (fi) * 2004-02-13 2004-02-13 Nokia Corp Laskutusinformaation tuottaminen viestintäjärjestelmässä

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663686A (en) * 1968-04-24 1972-05-16 Minnesota Mining & Mfg Biodegradable radioactive particles
US3663687A (en) * 1968-06-26 1972-05-16 Minnesota Mining & Mfg Biodegradable parenteral microspherules
US3725295A (en) * 1971-07-20 1973-04-03 Atomic Energy Commission Technetium labeling
CS208162B2 (en) * 1971-07-20 1981-08-31 Thomas A Haney Method of making the macroagregates of the technicium-99m,albumine and tin ion

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2366021A1 (fr) * 1974-08-29 1978-04-28 Union Carbide Corp Procede de preparation d'un support non radioactif stable destine au radiodiagnostic et consistant en un macro-agregat d'albumine
EP0508724A1 (en) * 1991-04-09 1992-10-14 Merck Frosst Canada Inc. Radiopharmaceutical bacteriostats
WO1993016735A1 (en) * 1992-02-28 1993-09-02 Order Stanley E Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor

Also Published As

Publication number Publication date
BE796962A (fr) 1973-09-19
IL41767A (en) 1976-06-30
JPS5328971B2 (enrdf_load_stackoverflow) 1978-08-17
AU472255B2 (en) 1976-05-20
DE2314059A1 (de) 1973-10-04
FR2182880B1 (enrdf_load_stackoverflow) 1976-04-09
GB1409176A (en) 1975-10-08
IT989625B (it) 1975-06-10
JPS4954517A (enrdf_load_stackoverflow) 1974-05-27
NL7303842A (enrdf_load_stackoverflow) 1973-09-24
AU5337573A (en) 1974-09-19
IL41767A0 (en) 1973-05-31
US3863004A (en) 1975-01-28

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Legal Events

Date Code Title Description
CD Change of name or company name
TP Transmission of property
ST Notification of lapse