GB1409176A - Protein composition for labelling with technetium-99m and method of preparation - Google Patents

Protein composition for labelling with technetium-99m and method of preparation

Info

Publication number
GB1409176A
GB1409176A GB1188673A GB1188673A GB1409176A GB 1409176 A GB1409176 A GB 1409176A GB 1188673 A GB1188673 A GB 1188673A GB 1188673 A GB1188673 A GB 1188673A GB 1409176 A GB1409176 A GB 1409176A
Authority
GB
United Kingdom
Prior art keywords
macroprotein
divalent tin
bound
technetium
labelling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1188673A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Chemical Works
Original Assignee
Mallinckrodt Chemical Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Chemical Works filed Critical Mallinckrodt Chemical Works
Publication of GB1409176A publication Critical patent/GB1409176A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB1188673A 1972-03-20 1973-03-13 Protein composition for labelling with technetium-99m and method of preparation Expired GB1409176A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US236159A US3863004A (en) 1972-03-20 1972-03-20 Denatured macroprotein with divalent tin for tagging with technetium-99m and method of preparation

Publications (1)

Publication Number Publication Date
GB1409176A true GB1409176A (en) 1975-10-08

Family

ID=22888369

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1188673A Expired GB1409176A (en) 1972-03-20 1973-03-13 Protein composition for labelling with technetium-99m and method of preparation

Country Status (10)

Country Link
US (1) US3863004A (enrdf_load_stackoverflow)
JP (1) JPS5328971B2 (enrdf_load_stackoverflow)
AU (1) AU472255B2 (enrdf_load_stackoverflow)
BE (1) BE796962A (enrdf_load_stackoverflow)
DE (1) DE2314059A1 (enrdf_load_stackoverflow)
FR (1) FR2182880B1 (enrdf_load_stackoverflow)
GB (1) GB1409176A (enrdf_load_stackoverflow)
IL (1) IL41767A (enrdf_load_stackoverflow)
IT (1) IT989625B (enrdf_load_stackoverflow)
NL (1) NL7303842A (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410507A (en) 1981-08-28 1983-10-18 Solco Basel Ag Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968221A (en) * 1972-05-05 1976-07-06 Medi-Physics, Inc. 99M-Technetium labeled tin colloid radiopharmaceuticals
US4024233A (en) * 1972-06-05 1977-05-17 Medi-Physics, Inc. 99M-technetium labeled macroaggregated human serum albumin pharmaceutical
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US3992513A (en) * 1975-01-07 1976-11-16 Atomic Energy Of Canada Limited Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs
US4057617A (en) * 1975-05-15 1977-11-08 Abramovici J Method of labeling proteins with technetium
GB1535847A (en) * 1976-03-19 1978-12-13 Radiochemical Centre Ltd Technetium-99m labelled tin colloid for body scanning
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same
US4226846A (en) * 1977-04-01 1980-10-07 New England Nuclear Corporation Albumin microaggregates for radioactive scanning of reticuloendothelial systems
US4337240A (en) * 1978-04-20 1982-06-29 New England Nuclear Corporation Denatured albumin complexes for radioscintigraphic imaging and evaluation of reticuloendothelial systems
DE3060377D1 (en) * 1979-08-29 1982-07-01 Nihon Mediphysics Co Ltd 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
JPS5645790U (enrdf_load_stackoverflow) * 1979-09-17 1981-04-24
US4406876A (en) * 1980-10-14 1983-09-27 Research Foundation Of The State Univ. Of New York Sulfur free small-particle production of technetium sulfur colloid
IT1194135B (it) * 1981-01-05 1988-09-14 Novo Industri As Composizioni di plasmina stabilizzata e metodo per la loro preparazione
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US5071965A (en) * 1988-07-19 1991-12-10 Mallinckrodt Medical, Inc. Novel tc-99m complexes
US5096696A (en) * 1990-02-05 1992-03-17 The Research Foundation Of State University Of New York Binding of radiolabeled albumin fragments to fibrin clots
US5137709A (en) * 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
US5306482A (en) * 1991-04-09 1994-04-26 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
AU3783893A (en) * 1992-02-28 1993-09-13 Stanley E. Order Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor
US6730286B2 (en) * 2001-02-28 2004-05-04 Bracco Diagnostics, Inc. Manufacturing process to control particle size
DE10317461A1 (de) * 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
FI20040240A0 (fi) * 2004-02-13 2004-02-13 Nokia Corp Laskutusinformaation tuottaminen viestintäjärjestelmässä

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663686A (en) * 1968-04-24 1972-05-16 Minnesota Mining & Mfg Biodegradable radioactive particles
US3663687A (en) * 1968-06-26 1972-05-16 Minnesota Mining & Mfg Biodegradable parenteral microspherules
US3725295A (en) * 1971-07-20 1973-04-03 Atomic Energy Commission Technetium labeling
CS208162B2 (en) * 1971-07-20 1981-08-31 Thomas A Haney Method of making the macroagregates of the technicium-99m,albumine and tin ion

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410507A (en) 1981-08-28 1983-10-18 Solco Basel Ag Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use

Also Published As

Publication number Publication date
BE796962A (fr) 1973-09-19
IL41767A (en) 1976-06-30
JPS5328971B2 (enrdf_load_stackoverflow) 1978-08-17
AU472255B2 (en) 1976-05-20
DE2314059A1 (de) 1973-10-04
FR2182880A1 (enrdf_load_stackoverflow) 1973-12-14
FR2182880B1 (enrdf_load_stackoverflow) 1976-04-09
IT989625B (it) 1975-06-10
JPS4954517A (enrdf_load_stackoverflow) 1974-05-27
NL7303842A (enrdf_load_stackoverflow) 1973-09-24
AU5337573A (en) 1974-09-19
IL41767A0 (en) 1973-05-31
US3863004A (en) 1975-01-28

Similar Documents

Publication Publication Date Title
GB1409176A (en) Protein composition for labelling with technetium-99m and method of preparation
Jeffrey et al. Axoplasmic transport
AU549204B2 (en) Intravenously injectable immune serum globulin
FI873141A0 (fi) Daeggdjurs interleukin-4.
DE122009000059I1 (de) Protein d- ein igd-bindendes protein von haemophilus influenzae
ATE114319T1 (de) Produktion von proteinen in aktiven formen.
CA2060314A1 (en) Low electroendosmosis agarose
SE8300320L (sv) Anvendning av en saltlosning av monoklonala antikroppar med relativt hog salthalt vid blodgruppsbestemning
GB1479851A (en) Chemical process
FI93842B (fi) Menetelmä proteiinien renaturoimiseksi
AU567747B2 (en) Early detection of mammalian pregnancy
GB1418849A (en) Production of antisera
Wikman-Coffelt et al. Differences in atrial and ventricular myosin light chain LC1
SE8601940D0 (sv) Preparation of fused proteins, antibodies and processes therefor
GB1372812A (en) Cerebrospinal fluid control standard
Torres et al. Concentration of proteins using carboxymethyldextran
ES448571A1 (es) Procedimiento para la estabilizacion de factor de aglutina- cion ligado a microorganismos.
GB1534956A (en) Method of labeling proteins with technetium
Saddi et al. Incorporation of14C-leucine into serum transferrin by slices and cell-free preparations of rat liver
SU968069A1 (ru) Способ стабилизации декстраназы реNIсILLIUм FUNIсULоSUм
GB859609A (en) Improvements in or relating to lyophilized protein hydrolysates
GB1302322A (enrdf_load_stackoverflow)
GB1418286A (en) Depyrogenation of urokinase
DE3686684D1 (de) Mittel zur absorptionsverbesserung von proteinen.
GB983489A (en) A tissue culture medium and a method of preparing same

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee