GB1418286A - Depyrogenation of urokinase - Google Patents

Depyrogenation of urokinase

Info

Publication number
GB1418286A
GB1418286A GB2742374A GB2742374A GB1418286A GB 1418286 A GB1418286 A GB 1418286A GB 2742374 A GB2742374 A GB 2742374A GB 2742374 A GB2742374 A GB 2742374A GB 1418286 A GB1418286 A GB 1418286A
Authority
GB
United Kingdom
Prior art keywords
urokinase
pyrogens
cellulose
contacting
depyrogenation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2742374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serna AG
Original Assignee
Serna AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serna AG filed Critical Serna AG
Publication of GB1418286A publication Critical patent/GB1418286A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6462Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21073Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

1418286 Removing pyrogens from urokinase SERNA AG 20 June 1974 [24 July 1973] 27423/74 Heading C3H A method for the removal of pyrogens from urokinase comprises contacting a pyrogenic urokinase preparation with an anion exchange cellulose, e.g. DEAE or TEAE cellulose and recovering substantially pyrogen-free urokinase therefrom. The contacting is preferably carried out by column chromatography using 0À001M phosphate buffer at pH 6-8 as the equilibrating buffer, the carrier and the eluent.
GB2742374A 1973-07-24 1974-06-20 Depyrogenation of urokinase Expired GB1418286A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1080073 1973-07-24

Publications (1)

Publication Number Publication Date
GB1418286A true GB1418286A (en) 1975-12-17

Family

ID=4366990

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2742374A Expired GB1418286A (en) 1973-07-24 1974-06-20 Depyrogenation of urokinase

Country Status (6)

Country Link
JP (1) JPS5069220A (en)
BE (1) BE818006A (en)
DE (1) DE2428248B2 (en)
FR (1) FR2238712B1 (en)
GB (1) GB1418286A (en)
IT (1) IT1034064B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000755A1 (en) * 1985-08-09 1987-02-12 Biotech Research Laboratories, Inc. Isolation of an endotoxin inactivator from human plasma

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957582A (en) * 1974-11-20 1976-05-18 Abbott Laboratories Purification of urokinase
JPS53113080A (en) * 1977-03-10 1978-10-03 Sumitomo Chem Co Ltd Purification of urokinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789189A (en) * 1971-09-24 1973-03-22 Choay Sa IMPROVEMENTS IN THE PROCESSES FOR PREPARATION, DEPYROGENATION AND STABILIZATION OF UROKINASE AND COMPOSITIONS OBTAINED

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000755A1 (en) * 1985-08-09 1987-02-12 Biotech Research Laboratories, Inc. Isolation of an endotoxin inactivator from human plasma

Also Published As

Publication number Publication date
DE2428248A1 (en) 1975-02-13
BE818006A (en) 1974-11-18
FR2238712A1 (en) 1975-02-21
DE2428248C3 (en) 1978-09-21
DE2428248B2 (en) 1978-01-12
JPS5069220A (en) 1975-06-10
IT1034064B (en) 1979-09-10
FR2238712B1 (en) 1977-06-24

Similar Documents

Publication Publication Date Title
CA1016008A (en) Process for bland, soluble protein
SE8200715L (en) PYROGEN CONTENT REDUCTION
GB1534812A (en) Method for the purification of interferon
ES8504247A1 (en) Method for production of an immobilized enzyme preparation by means of a crosslinking agent
GB908333A (en) Method for the production of substantially protein-free callicrein
GB1310372A (en) Phenoxyethylammonium compounds a process for their manufacture and plant growth-regulating preparations containing them
GB1440369A (en) Purification of coenzyme a
GB1418286A (en) Depyrogenation of urokinase
GB1426483A (en) Vincamine derivatives and process for the preparation of vincamine and derivatives thereof
FR2575466B1 (en) NOVEL HEXACOORDIN SILICON COMPLEXES, THEIR PREPARATION PROCESS AND THEIR APPLICATION
GB1533906A (en) Process for reducing the water sensitivity of polyvinyl alcohol
ES443458A1 (en) Process for purifying thienamycin
GB1436684A (en) Method for preparing glucoronyl-glucosamino-glycan sulphates exhibiting antilipaemic activity
AU7671087A (en) Method for purifying and isolating two ionic forms of somatomedin C
ES400225A1 (en) Antibiotic purification processes
BE825156A (en) PROCESS FOR PREPARING 7-AMINO ACID DERIVATIVES,
GB1463327A (en) Method of isolating transferrines from biological materials
GB1324159A (en) Process for producing 7-amino desacetoxy cephalosporanic acid
BG96578A (en) METHOD FOR OBTAINING PURIFIED LYSOZYME DIMERS
BE762804A (en) PROCESS FOR PREPARING DERIVATIVES OF ALKYL-1 NAPHTYRIDINE (-1.8)
SE8403929L (en) RECOMBINANT DNA MOLECULE, TRANSFORMED MICROORGANISMS AND PROCEDURE FOR PENICILLIN V-AMIDAS PREPARATION
GB1464647A (en) Process for the preparation of choleragen
GB1235909A (en) Purification of boric acid
IE840280L (en) Anthracycline compound
GB1384684A (en) 1,3,5-triazine and process for the preparation thereof

Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19940619