GB1418286A - Depyrogenation of urokinase - Google Patents
Depyrogenation of urokinaseInfo
- Publication number
- GB1418286A GB1418286A GB2742374A GB2742374A GB1418286A GB 1418286 A GB1418286 A GB 1418286A GB 2742374 A GB2742374 A GB 2742374A GB 2742374 A GB2742374 A GB 2742374A GB 1418286 A GB1418286 A GB 1418286A
- Authority
- GB
- United Kingdom
- Prior art keywords
- urokinase
- pyrogens
- cellulose
- contacting
- depyrogenation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
1418286 Removing pyrogens from urokinase SERNA AG 20 June 1974 [24 July 1973] 27423/74 Heading C3H A method for the removal of pyrogens from urokinase comprises contacting a pyrogenic urokinase preparation with an anion exchange cellulose, e.g. DEAE or TEAE cellulose and recovering substantially pyrogen-free urokinase therefrom. The contacting is preferably carried out by column chromatography using 0À001M phosphate buffer at pH 6-8 as the equilibrating buffer, the carrier and the eluent.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1080073 | 1973-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1418286A true GB1418286A (en) | 1975-12-17 |
Family
ID=4366990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2742374A Expired GB1418286A (en) | 1973-07-24 | 1974-06-20 | Depyrogenation of urokinase |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS5069220A (en) |
BE (1) | BE818006A (en) |
DE (1) | DE2428248B2 (en) |
FR (1) | FR2238712B1 (en) |
GB (1) | GB1418286A (en) |
IT (1) | IT1034064B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987000755A1 (en) * | 1985-08-09 | 1987-02-12 | Biotech Research Laboratories, Inc. | Isolation of an endotoxin inactivator from human plasma |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3957582A (en) * | 1974-11-20 | 1976-05-18 | Abbott Laboratories | Purification of urokinase |
JPS53113080A (en) * | 1977-03-10 | 1978-10-03 | Sumitomo Chem Co Ltd | Purification of urokinase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE789189A (en) * | 1971-09-24 | 1973-03-22 | Choay Sa | IMPROVEMENTS IN THE PROCESSES FOR PREPARATION, DEPYROGENATION AND STABILIZATION OF UROKINASE AND COMPOSITIONS OBTAINED |
-
1974
- 1974-06-12 DE DE19742428248 patent/DE2428248B2/en active Granted
- 1974-06-20 GB GB2742374A patent/GB1418286A/en not_active Expired
- 1974-06-28 IT IT2454174A patent/IT1034064B/en active
- 1974-07-15 JP JP8026674A patent/JPS5069220A/ja active Pending
- 1974-07-23 FR FR7425461A patent/FR2238712B1/fr not_active Expired
- 1974-07-23 BE BE146867A patent/BE818006A/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987000755A1 (en) * | 1985-08-09 | 1987-02-12 | Biotech Research Laboratories, Inc. | Isolation of an endotoxin inactivator from human plasma |
Also Published As
Publication number | Publication date |
---|---|
DE2428248A1 (en) | 1975-02-13 |
BE818006A (en) | 1974-11-18 |
FR2238712A1 (en) | 1975-02-21 |
DE2428248C3 (en) | 1978-09-21 |
DE2428248B2 (en) | 1978-01-12 |
JPS5069220A (en) | 1975-06-10 |
IT1034064B (en) | 1979-09-10 |
FR2238712B1 (en) | 1977-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19940619 |