GB1534956A - Method of labeling proteins with technetium - Google Patents

Method of labeling proteins with technetium

Info

Publication number
GB1534956A
GB1534956A GB1893976A GB1893976A GB1534956A GB 1534956 A GB1534956 A GB 1534956A GB 1893976 A GB1893976 A GB 1893976A GB 1893976 A GB1893976 A GB 1893976A GB 1534956 A GB1534956 A GB 1534956A
Authority
GB
United Kingdom
Prior art keywords
technetium
protein
pertechnetate
reduced
labeling proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1893976A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ERMANS A
JEGHERS O
Original Assignee
ERMANS A
JEGHERS O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE156396A external-priority patent/BE829128A/en
Priority claimed from BE159144A external-priority patent/BE832363R/en
Application filed by ERMANS A, JEGHERS O filed Critical ERMANS A
Publication of GB1534956A publication Critical patent/GB1534956A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1534956 Labelling proteins with Tc<SP>99</SP> J ABRAMOUICI A-M ERMANS and O JEGHERS 7 May 1976 [15 May 1975 12 Aug 1975] 18939/76 Heading C3H In a method of labelling proteins with 99m technetium, pertechnetate is reduced and the reduced pertechnetate is put into contact with at least one protein from the group comprising fibrinogen and immunoglobulins so as to label the protein, the method being characterized in that the pertechnetate is reduced in the presence of a reducing agent at a pH between 11 and 12 and the resulting mixture containing the protein labelled with technetium is purified by removing unwanted degradation products of the protein and non-bound technetium.
GB1893976A 1975-05-15 1976-05-07 Method of labeling proteins with technetium Expired GB1534956A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE156396A BE829128A (en) 1975-05-15 1975-05-15 PROTEIN MARKING PROCESS USING TECHNETIUM
BE159144A BE832363R (en) 1975-08-12 1975-08-12 PROTEIN MAROUAGE PROCESS USING TECHNITIUM

Publications (1)

Publication Number Publication Date
GB1534956A true GB1534956A (en) 1978-12-06

Family

ID=25648599

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1893976A Expired GB1534956A (en) 1975-05-15 1976-05-07 Method of labeling proteins with technetium

Country Status (5)

Country Link
JP (1) JPS51142521A (en)
CH (1) CH613177A5 (en)
DE (1) DE2621311C3 (en)
GB (1) GB1534956A (en)
SE (1) SE7605350L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159443A (en) * 1999-04-29 2000-12-12 Vanderbilt University X-ray guided drug delivery
US7049140B1 (en) 1999-04-29 2006-05-23 Vanderbilt University X-ray guided drug delivery
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
US7306925B2 (en) 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
US10449261B2 (en) 2014-07-24 2019-10-22 Washington University Compositions targeting radiation-induced molecules and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786566A (en) * 1971-07-20 1973-01-22 Squibb & Sons Inc TC-99M AND ALBUMIN AGGREGATES

Also Published As

Publication number Publication date
CH613177A5 (en) 1979-09-14
DE2621311A1 (en) 1976-11-18
DE2621311B2 (en) 1980-07-31
JPS51142521A (en) 1976-12-08
DE2621311C3 (en) 1981-04-30
SE7605350L (en) 1976-11-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee