DE2235681A1 - Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen - Google Patents

Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen

Info

Publication number
DE2235681A1
DE2235681A1 DE2235681A DE2235681A DE2235681A1 DE 2235681 A1 DE2235681 A1 DE 2235681A1 DE 2235681 A DE2235681 A DE 2235681A DE 2235681 A DE2235681 A DE 2235681A DE 2235681 A1 DE2235681 A1 DE 2235681A1
Authority
DE
Germany
Prior art keywords
macroaggregates
albumin
tin
solution
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2235681A
Other languages
German (de)
English (en)
Inventor
Janet Marie Bartlett
Gerald Anthony Bruno
Haney Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE2235681A1 publication Critical patent/DE2235681A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE2235681A 1971-07-20 1972-07-20 Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen Ceased DE2235681A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16445671A 1971-07-20 1971-07-20
US265849A US3872226A (en) 1971-07-20 1972-06-23 Tc{14 99m albumin aggregates with stannous tin and denatured albumin

Publications (1)

Publication Number Publication Date
DE2235681A1 true DE2235681A1 (de) 1973-02-08

Family

ID=26860576

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2235681A Ceased DE2235681A1 (de) 1971-07-20 1972-07-20 Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen

Country Status (9)

Country Link
US (1) US3872226A (xx)
BE (1) BE786566A (xx)
CA (1) CA1011653A (xx)
CH (1) CH563776A5 (xx)
DE (1) DE2235681A1 (xx)
FR (1) FR2146437B1 (xx)
IT (1) IT1048987B (xx)
NL (1) NL178130C (xx)
SE (1) SE417896B (xx)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534985A1 (de) * 1974-08-06 1976-02-19 Commissariat Energie Atomique Verfahren zum markieren mit 99 m technetium
DE2621311A1 (de) * 1975-05-15 1976-11-18 Abramovici J Verfahren zum markieren von proteinen mit technetium 99 hoch m
DE2617922A1 (de) * 1975-05-27 1976-12-09 Byk Mallinckrodt Chem Prod Verfahren zur herstellung von lyophilisierten produkten
DE2814038A1 (de) * 1977-04-01 1978-10-05 New England Nuclear Corp Zur verwendung mit einem radionuklid bestimmtes albuminhaltiges diagnostikum

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024233A (en) * 1972-06-05 1977-05-17 Medi-Physics, Inc. 99M-technetium labeled macroaggregated human serum albumin pharmaceutical
GB1389809A (en) * 1972-06-05 1975-04-09 Medi Physics Inc 99m-technetium labeled macroaggregated human serum albumin pharmaceutical
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US4042677A (en) * 1974-08-29 1977-08-16 Union Carbide Corporation Technetium-99m labeled radiodiagnostic agents and method of preparation
US3992513A (en) * 1975-01-07 1976-11-16 Atomic Energy Of Canada Limited Labelled phospholipid material colloidially dispersed and sized to localize at preselected organs
US4057617A (en) * 1975-05-15 1977-11-08 Abramovici J Method of labeling proteins with technetium
GB1535847A (en) * 1976-03-19 1978-12-13 Radiochemical Centre Ltd Technetium-99m labelled tin colloid for body scanning
US4187285A (en) * 1977-12-16 1980-02-05 E. R. Squibb & Sons, Inc. Microaggregated albumin
US4424200A (en) 1979-05-14 1984-01-03 Nuc Med Inc. Method for radiolabeling proteins with technetium-99m
US4406876A (en) * 1980-10-14 1983-09-27 Research Foundation Of The State Univ. Of New York Sulfur free small-particle production of technetium sulfur colloid
CH652599A5 (de) * 1981-08-28 1985-11-29 Solco Basel Ag Verfahren zur herstellung physiologisch abbaubarer kolloidaler, human-serumalbumin enthaltender produkte und ihre verwendung.
US5208007A (en) * 1988-11-22 1993-05-04 Board Of Regents Of The University Of Oklahoma Isotopic tracer composition and method for making and using same
US6730286B2 (en) * 2001-02-28 2004-05-04 Bracco Diagnostics, Inc. Manufacturing process to control particle size
US8551162B2 (en) * 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725295A (en) * 1971-07-20 1973-04-03 Atomic Energy Commission Technetium labeling

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534985A1 (de) * 1974-08-06 1976-02-19 Commissariat Energie Atomique Verfahren zum markieren mit 99 m technetium
DE2621311A1 (de) * 1975-05-15 1976-11-18 Abramovici J Verfahren zum markieren von proteinen mit technetium 99 hoch m
DE2617922A1 (de) * 1975-05-27 1976-12-09 Byk Mallinckrodt Chem Prod Verfahren zur herstellung von lyophilisierten produkten
DE2814038A1 (de) * 1977-04-01 1978-10-05 New England Nuclear Corp Zur verwendung mit einem radionuklid bestimmtes albuminhaltiges diagnostikum

Also Published As

Publication number Publication date
NL178130B (nl) 1985-09-02
FR2146437B1 (xx) 1976-07-02
FR2146437A1 (xx) 1973-03-02
CA1011653A (en) 1977-06-07
IT1048987B (it) 1980-12-20
CH563776A5 (xx) 1975-07-15
US3872226A (en) 1975-03-18
NL178130C (nl) 1986-02-03
SE417896B (sv) 1981-04-27
NL7210027A (xx) 1973-01-23
BE786566A (fr) 1973-01-22

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