DE2223365C3 - Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate - Google Patents

Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate

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Publication number
DE2223365C3
DE2223365C3 DE2223365A DE2223365A DE2223365C3 DE 2223365 C3 DE2223365 C3 DE 2223365C3 DE 2223365 A DE2223365 A DE 2223365A DE 2223365 A DE2223365 A DE 2223365A DE 2223365 C3 DE2223365 C3 DE 2223365C3
Authority
DE
Germany
Prior art keywords
radical
compounds
carbon atoms
formula
stands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2223365A
Other languages
German (de)
English (en)
Other versions
DE2223365B2 (de
DE2223365A1 (de
Inventor
Neville Stanton Macclesfield Cheshire Crossley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3967272A external-priority patent/GB1348036A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE2223365A1 publication Critical patent/DE2223365A1/de
Publication of DE2223365B2 publication Critical patent/DE2223365B2/de
Application granted granted Critical
Publication of DE2223365C3 publication Critical patent/DE2223365C3/de
Expired legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/535Organo-phosphoranes
    • C07F9/5352Phosphoranes containing the structure P=C-
DE2223365A 1971-05-11 1972-05-12 Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate Expired DE2223365C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1413971 1971-05-11
GB3967272A GB1348036A (en) 1970-05-15 1972-01-05 Transistorized vertical deflection circuit

Publications (3)

Publication Number Publication Date
DE2223365A1 DE2223365A1 (de) 1972-12-07
DE2223365B2 DE2223365B2 (de) 1980-07-31
DE2223365C3 true DE2223365C3 (de) 1981-06-04

Family

ID=26235892

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2223365A Expired DE2223365C3 (de) 1971-05-11 1972-05-12 Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate

Country Status (26)

Country Link
JP (1) JPS5611699B1 (es)
AR (4) AR194952A1 (es)
AT (4) AT328103B (es)
AU (1) AU462755B2 (es)
BE (1) BE783292A (es)
CA (1) CA1077033A (es)
CH (3) CH596166A5 (es)
CS (1) CS192456B2 (es)
DD (1) DD99155A5 (es)
DE (1) DE2223365C3 (es)
DK (1) DK134598B (es)
EG (1) EG10752A (es)
ES (1) ES402627A1 (es)
FI (1) FI63221C (es)
FR (1) FR2137712A1 (es)
HK (1) HK50176A (es)
HU (1) HU166717B (es)
IE (1) IE37602B1 (es)
IL (1) IL39376A (es)
KE (1) KE2634A (es)
NL (1) NL164272C (es)
NO (1) NO139521C (es)
SE (4) SE399705B (es)
SU (1) SU662007A3 (es)
YU (1) YU35876B (es)
ZM (1) ZM8172A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
DD118856A5 (es) * 1972-11-08 1976-03-20
US3966795A (en) * 1973-05-21 1976-06-29 The Upjohn Company 5-Oxa-11-deoxyphenyl- and phenoxy-substituted prostaglandin F1.sub.α analogs
US3968144A (en) * 1973-05-21 1976-07-06 The Upjohn Company 5-Oxa-11-deoxy phenyl- and phenoxy-substituted prostalandin E1 analogs
US4387241A (en) * 1974-11-01 1983-06-07 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4149006A (en) * 1977-01-24 1979-04-10 G. D. Searle & Co. Prostaglandin derivatives having alkynyl, hydroxy and aryloxy junctions in the 2β side chain
US4191774A (en) * 1978-01-18 1980-03-04 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Novel 17-aza-PGF2α derivatives and pharmaceutical compositions containing the same
US4228296A (en) * 1979-01-24 1980-10-14 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
CS264861B1 (en) * 1986-12-12 1989-09-12 Kral Josef Agent for cow natality increase
CS265947B1 (en) * 1987-06-16 1989-11-14 Kral Josef Means for farming animals' ovarian functions control
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
CS276003B6 (en) * 1988-09-28 1992-03-18 Spolana method of production of (+)-isomer of cloprostenol
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
UA99840C2 (ru) * 2007-11-09 2012-10-10 Аллерган, Инк. Замещенные циклопентаны, которые имеют простагландиновую активность

Also Published As

Publication number Publication date
IE37602L (en) 1972-11-11
AT328105B (de) 1976-03-10
DE2223365B2 (de) 1980-07-31
IL39376A (en) 1975-07-28
YU35876B (en) 1981-08-31
FI63221C (fi) 1983-05-10
YU125072A (en) 1981-02-28
ES402627A1 (es) 1975-11-01
NO139521B (no) 1978-12-18
AT333447B (de) 1976-11-25
SE7504337L (sv) 1975-04-15
FR2137712A1 (en) 1972-12-29
DK134598B (da) 1976-12-06
NO139521C (no) 1979-03-28
ATA539073A (de) 1975-05-15
BE783292A (fr) 1972-11-10
NL164272C (nl) 1980-12-15
AT328104B (de) 1976-03-10
SE7504336L (es) 1975-04-15
IL39376A0 (en) 1972-07-26
CH596165A5 (es) 1978-02-28
CH590223A5 (es) 1977-07-29
ATA538973A (de) 1975-05-15
AR197100A1 (es) 1974-03-15
AR194952A1 (es) 1973-08-30
HK50176A (en) 1976-08-13
JPS5611699B1 (es) 1981-03-16
NL164272B (nl) 1980-07-15
FR2137712B1 (es) 1976-04-16
ZM8172A1 (en) 1973-01-22
DK134598C (es) 1977-05-16
AU4202472A (en) 1973-11-15
ATA539173A (de) 1975-05-15
EG10752A (en) 1976-05-31
AR200484A1 (es) 1974-11-15
CA1077033A (en) 1980-05-06
NL7206361A (es) 1972-11-14
DD99155A5 (es) 1973-07-20
CS192456B2 (en) 1979-08-31
SE399705B (sv) 1978-02-27
CH596166A5 (es) 1978-02-28
ATA419172A (de) 1976-03-15
SE7504335L (es) 1975-04-15
FI63221B (fi) 1983-01-31
AU462755B2 (en) 1975-07-03
SU662007A3 (ru) 1979-05-05
AT328103B (de) 1976-03-10
KE2634A (en) 1976-06-11
IE37602B1 (en) 1977-08-31
AR197101A1 (es) 1974-03-15
DE2223365A1 (de) 1972-12-07
HU166717B (es) 1975-05-28

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)